Improving Mechanics and Confidence in the Hip Hinge
Recruiting
To evaluate if the Founder exercise will significantly change participants kinematics when performing hip hinge movement. Secondary purpose is to evaluate if completing the Founder Exercise intervention will improve confidence in performing a hip hinge.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/06/2025
Locations: University of Central Florida, Orlando, Florida
Conditions: Hip Hinge, Hip and Knee Movement
Intervention to Enhance PrEP Persistence
Recruiting
The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention for Black/African American (B/AA) men who have sex with men (MSM) on PrEP initiation, adherence and retention in care. B/AA men who have sex with men (MSM) are disproportionately impacted by the HIV/AIDS epidemic in the United States. Pre-exposure prophylaxis (PrEP), a once daily medication, can dramatically reduce HIV acquisition risk. However, social and stru... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Whitman Walker Health, Washington, District of Columbia +2 locations
Conditions: HIV Prevention, HIV Infection Primary
Allo HSCT for High Risk Hemoglobinopathies
Recruiting
A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent disorders utilizing allogeneic hematopoietic stem cell transplantation (HSCT) regimens.
Gender:
ALL
Ages:
55 years and below
Trial Updated:
03/06/2025
Locations: Masonic Cancer Center, Minneapolis, Minnesota
Conditions: Graft Failure, Sickle Cell Disease, Hemoglobinopathies
Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults
Recruiting
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy. More and more research is showing that regular environmental stress, for example heat and hypoxia, can further improve physical health. Astronauts aboard the international space station (ISS) exercise for 1-2 hours every day to avoid physical deconditioning that would otherwise cause them to age rapidly i... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/06/2025
Locations: Northern Arizona University, Flagstaff, Arizona
Conditions: Exercise, Heat Strain, Control Condition
Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
Recruiting
Systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are long-term autoimmune diseases in which the immune system attacks parts of the body. The abnormal immune reaction causes inflammation of and damage to various body parts and can affect joints, skin, kidneys, heart, lungs, blood vessels, and the brain. SLE and MCTD often affect young women, especially black and Hispanic women, and there is no known cure. Knowing more about SLE and MCTD will help in developing new and... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/05/2025
Locations: University of Miami Miller School of Medicine, Miami, Florida
Conditions: Mixed Connective Tissue Disease (MCTD), Systemic Lupus Erythematosus (SLE)
Testicular Tissue Cryopreservation for Fertility Preservation
Recruiting
Testicular tissue cryopreservation is an experimental procedure where a young boy's testicular tissue is retrieved and frozen. This technique is reserved for young male patients who are not yet producing mature sperm, with the ultimate goal that their tissue may be used in the future to restore fertility when experimental techniques emerge from the research pipeline.
Gender:
MALE
Ages:
All
Trial Updated:
03/05/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Cancer, Autoimmune Disorders
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
Recruiting
One in three American adults have prediabetes, and up to 70% of adults with prediabetes eventually develop type 2 diabetes. With the high cost of treating diabetes, cost-effective approaches are needed to reduce the incidence of diabetes. One new strategy may be to change when people eat. Studies in rodents suggest that a form of intermittent fasting that limits eating to a short time period each day and involves fasting for the rest of the day (time-restricted eating; TRE) improves blood sugar... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
03/05/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: PreDiabetes
Blood Donor CVD 5000
Recruiting
This is an open-label, non-randomized study. Volunteers will be vaccinated with the typhoid oral vaccine, Vivotif. Vivotif has been licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will also be asked to provide blood, saliva, and stool specimens over a follow-up time period of up to eight years. The specimens obtained in this clinical research study will be used to further the investigator's understanding of the protective immunological mechani... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Maryland, Baltimore, Center for Vaccine Development and Global Health, Baltimore, Maryland
Conditions: Risk Reduction
Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer
Recruiting
This phase II trial studies how well olaparib with cediranib or AZD6738 works in treating patients with germline BRCA mutated breast cancer that has spread to other places in the body (advanced or metastatic). Olaparib, cediranib, and AZD6738 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Advanced Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation, HER2/Neu Negative, Metastatic Breast Carcinoma, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Prognostic Stage IV Breast Cancer AJCC v8
High-resolution Phosphocreatine and Creatine Mapping of Human Muscle and Brain
Recruiting
In this study, we aim to develop and validate a noninvasive approach for quantifying and imaging energy metabolism, without contrast agents, on widely available clinical MRI scanners. Briefly, this technique allows specific and selective imaging of the energy metabolite phosphocreatine (PCr), in vivo and non-invasively. PCr is one of the predominant high-energy phosphates present in brain and muscle and one that is altered by common diseases. Although energy metabolism and PCr play a vital role... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: F. M. Kirby Center and Johns Hopkins University Medical School, Baltimore, Maryland
Conditions: Healthy
IV Gallium Study for Patients with Cystic Fibrosis Who Have NTM (ABATE Study)
Recruiting
The purpose of this study is to assess the safety and tolerability of two 5-day infusion cycles of IV gallium in adult patients with CF who are infected with NTM. Funding Source - FDA Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +9 locations
Conditions: Nontuberculous Mycobacterium Infection
Early Use of Long-acting Tacrolimus in Lung Transplant Recipients
Recruiting
Lung transplantation is a life-saving therapy for patients with advanced lung disease, however, necessitates the use of life-long immunosuppressive therapy for the prevention of acute and chronic rejection. The backbone of immunosuppression is the calcineurin-inhibitor class, with tacrolimus being the preferred drug due to its potency and improved side-effect profile. Nevertheless, tacrolimus is associated with several side effects including increased risk for infection and malignancy, tremors,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Lung Transplant; Complications