Concurrent Azeliragon With Craniospinal Irradiation
NCT06724926
Recruiting
Single institution study to assess the safety of concurrent Azeliragon with craniospinal irradiation (CSI) in patients with leptomeningeal metastasis from solid tumor malignancies and high-grade gliomas.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: NYU Langone Health, New York, New York
Conditions: Solid Tumor, High-grade Glioma, Leptomeningeal Metastasis
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Integrity Implant System Post Market Clinical Follow-Up Study
NCT06741527
Recruiting
The study design is a prospective, multi-center, single-arm, non-randomized post market clinical follow-up study to confirm the performance, safety and clinical benefit of the Integrity Implant System when used for rotator cuff tear augmentation (with or without repair).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Foundation for Orthopaedic Research and Education, Tampa, Florida +6 locations
Conditions: Rotator Cuff Tears of the Shoulder
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Novel INPUT Screening Tool to Improve Illness Understanding in Patients With Metastatic or Incurable Lung Cancer
NCT06743308
Recruiting
This clinical trial compares the use of a new screening tool designed to evaluate patients' information needs, preferences, and illness understanding to the usual care to improve illness understanding in patients with lung cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or for which no curative treatment is currently available (incurable). Goal concordant care is a model of care that aligns a patient's medical care with their values, pre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Lung Carcinoma, Metastatic Lung Carcinoma, Stage IV Lung Cancer AJCC v8
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Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery
NCT06826742
Recruiting
The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg) intravenous methadone.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cesarean Delivery
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Retrospective Study of AlloMend Acellular Dermal Matrix (ADM) Allograft and Pre-Pectoral Breast Reconstruction
NCT06853964
Recruiting
This retrospective, single-site study will provide information regarding the efficiency of AlloMend® Acellular Dermal Matrix allograft in Pre-Pectoral Breast Reconstruction surgery following a single or double mastectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Janiga MDs Plastic Surgery and Cosmetic Center, Reno, Nevada
Conditions: Pre-Pectoral Breast Reconstruction Following Mastectomy
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R3THA Rehabilitation Feasibility and Usability Study
NCT06854978
Recruiting
The purpose of this study is to assess how the Rehabilitation Technologies for Hand and Arm (R3THA) device can be used for rehabilitation of people with stroke. the study will evaluate the feasibility of R3THA as outpatient telerehabilitation administered by trained clinicians to individuals with stroke.
Gender:
ALL
Ages:
Between 20 years and 80 years
Trial Updated:
02/28/2025
Locations: Kessler Foundation, West Orange, New Jersey
Conditions: Stroke
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Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
NCT06860724
Recruiting
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age adults and the extent to which this association is impacted by major depressive disorder (MDD).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
02/28/2025
Locations: University of Delaware, Newark, Delaware
Conditions: Major Depressive Disorder
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A Palliative Care Model Impact on Knowledge and Attitudes
NCT06860932
Recruiting
This study is using a central, computer-generated simple randomization technique. Participants will be randomly assigned to groups within the constraints of ensuring balanced representation of gender, ethnicity, and race. One-half of the patients are randomized to the decision aid video model, and one-half will serve as controls and receive a palliative care (PC) informational sheet. Sessions are designed to be consistent with PC principles of care using constructs from the Murray's transition... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/28/2025
Locations: Judith Jaffe Multiple Sclerosis Center, New York, New York +1 locations
Conditions: Multiple Sclerosis, MS
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Evaluation of the Safety and Tolerability of Gemini in Subjects With Stage 3-4 Chronic Kidney Disease.
NCT06863467
Recruiting
Gemini is being evaluated in a placebo controlled, single dose, escalating dose study to evaluate the safety and tolerability of intravenous Gemini in adult subjects with stage 3 or 4 chronic kidney disease. Pharmacokinetics will be evaluated and measurements of the effect of Gemini on pharmacodynamic activity will be measured to assess changes in potential pharmacodynamic markers.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/28/2025
Locations: California Institute of Renal Research, Chula Vista, California +2 locations
Conditions: Renal Insufficiency, Chronic, Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
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Molecular and Genomic Profiling of Head and Neck Tumors
NCT00200486
Recruiting
The purpose of this study is to study the genetic profile of head and neck tumors and their relationship to treatment response and outcome
Gender:
ALL
Ages:
All
Trial Updated:
02/27/2025
Locations: Stelby Augustine, Bronx, New York
Conditions: Head and Neck Neoplasms
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Cervical Cancer Detection Using Optical Spectroscopy
NCT00900575
Recruiting
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cervical Cancer
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Collection and Storage of Tissue and Blood Samples From Patients With Cancer
NCT02474160
Recruiting
This study collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
02/27/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +139 locations
Conditions: Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
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