Observational Study of Bone Complications in People With Post-menopausal Breast Cancer Who Have Stopped Treatment With Denosumab and Aromatase Inhibitors
NCT05590949
Recruiting
The purpose of this study to gather information about changes in the bones after stopping treatment with aromatase inhibitor/AI and denosumab. The study team will collect information from 5 standard clinic visits over the course of 24 months. The information will include information about participant health assessments, blood test results, and imaging results. After 24 months, participation in this study will be complete.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Breast Cancer
Register for Updates
Optimizing CBSST with Executive Function Training for Schizophrenia
NCT06251193
Recruiting
The purpose of this research study to test a blended intervention that combines Executive Function Training with Cognitive-Behavioral Skills Training (E-CBSST). The aims include determining whether E-CBSST is feasible and increases Cognitive Behavioral Social Skills Training (CBSST) Skills Learning to a level that will lead to a clinically meaningful improvement in functioning.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/01/2024
Locations: UC San Diego, La Jolla, California +1 locations
Conditions: Schizophrenia, Schizoaffective Disorder
Register for Updates
Glucagon-like Peptide-1 in Type 1 Diabetes
NCT04355832
Recruiting
The hypotheses to be tested in this application is: GLP-1 will acutely protect arterial endothelial function and reduce pro-atherothrombotic and pro-coagulant effects of repeated hypoglycemia in T1DM.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/01/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Type1 Diabetes Mellitus
Register for Updates
Erector Spinae Plane Block for Uncomplicated Renal Colic
NCT05625802
Recruiting
This research study is to determine how well the Erector Spinae Plane Block (ESPB) works for kidney stone pain and any possible side effects.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: The University of Michigan, Ann Arbor, Michigan
Conditions: Renal Colic, Kidney Stone
Register for Updates
Study to Evaluate LB-LR1109 for the Treatment of Solid Tumors
NCT06332755
Recruiting
This is a Phase 1, first-in-human (FIH), multi-center, open-label, non-randomized, dose escalation study, designed to determine the Maximum tolerated dose(MTD)/Recommended Phase 2 dose(RP2D) of LB-LR1109 and to evaluate safety, tolerability, preliminary efficacy, pharmacokinetics, immunogenicity, pharmacodynamics of LB-LR1109, and its impact on quality of life in participants with unresectable and metastatic nonsmall cell lung cancer(NSCLC), head and neck squamous cell carcinoma(HNSCC), renal ce... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: NEXT Oncology, Fairfax, Virginia
Conditions: Non-small Cell Lung Cancer(NSCLC), Head and Neck Squamous Cell Carcinoma(HNSCC), Renal Cell Carcinoma(RCC), Urothelial Carcinoma, Malignant Melanoma
Register for Updates
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
NCT04579588
Recruiting
The purpose of this study is to measure immunity to the flu vaccine over time in patients who have had COVID-19 and may have other medical conditions including obesity, type 2 diabetes, chronic fatigue, or long-term COVID-19 symptoms. Adults and children (age 13 to 64) who had been diagnosed with COVID-19 as well as controls without COVID-19 will be invited to participate in this study.
Gender:
ALL
Ages:
Between 13 years and 64 years
Trial Updated:
11/01/2024
Locations: Stanford University, Palo Alto, California
Conditions: Corona Virus Infection, Flu Vaccine, Immunity
Register for Updates
Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.
NCT05634512
Recruiting
This is a prospective, observational multicenter study to collect blood from patients with mucopolysaccharidosis type IH undergoing laronidase therapy and a stem cell transplant. Sixteen patients will be enrolled over a 24 month period.
Gender:
ALL
Ages:
Between 0 years and 3 years
Trial Updated:
11/01/2024
Locations: University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota
Conditions: Hematopoietic Cell Transplantation, Mucopolysaccharidosis Type I
Register for Updates
Study to Assess Drug Levels and Safety of Golcadomide (BMS-986369) in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
NCT06535399
Recruiting
The purpose of this study is to assess the drug levels and safety of golcadomide (BMS-986369) in adult participants with moderate and severe Hepatic Impairment (HI), and in matched healthy control participants with normal hepatic function.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/01/2024
Locations: Arizona Liver Health, Chandler, Arizona +5 locations
Conditions: Hepatic Impairment, Healthy Volunteers
Register for Updates
A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients with DLBCL
NCT04594798
Recruiting
The purpose of this study is to test the effectiveness and safety of polatuzumab vedotin in combination with R-miniCHP in patients 75 years and older with DLBCL.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
11/01/2024
Locations: University of Rochester, Rochester, New York
Conditions: DLBCL, Lymphoma, B-Cell
Register for Updates
ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
NCT05682443
Recruiting
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: University of California at Davis Cancer Center - 1624, Davis, California +21 locations
Conditions: Metastatic Castration-resistant Prostate Cancer
Register for Updates
Comparison of Compounded Topical Anesthetics
NCT06569537
Recruiting
The primary objective for this pilot study is to evaluate the efficacy of the compounded topical anesthetic Benzocaine 20%/ Lidocaine 8%/Tetracaine 4% (BLT) compared to 4% Lidocaine topical in providing relief of pain during IPL, PDL, and microneedling procedures.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/01/2024
Locations: Dartmouth Hitchcock Dermatology Clinic, Lebanon, New Hampshire
Conditions: Procedural Pain
Register for Updates
RA-PRO PRAGMATIC TRIAL
NCT04692493
Recruiting
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: East Alabama Arthritis Center PC, Auburn, Alabama +48 locations
Conditions: Rheumatoid Arthritis
Register for Updates