Connect to Baby: A Pilot Study of a Parenting and Coparenting Program
Recruiting
The proposed project is a randomized control trial to assess a novel 6-session parenting and coparenting intervention for low-income parents of infants. Connect to Baby (CTB) will be implemented within one of the largest federally-funded early care and education programs, Early Head Start (EHS), in Washington, DC. To engage both fathers and mothers, CTB recruits parents at the time of birth, capitalizing on the "magic moment" of delivery, and uses father-inclusive digital media content to engage... Read More
Gender:
ALL
Ages:
Between 2 months and 40 years
Trial Updated:
08/18/2025
Locations: Child Development and Social Policy Lab, Washington, District of Columbia
Conditions: Parenting
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Recruiting
This study is conducted to determine the safety and tolerability of INCB161734 as a single agent or in combination with other anticancer therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Mayo Clinic Hospital, Phoenix, Arizona +31 locations
Conditions: Solid Tumors, Pancreatic Ductal Adenocarcinoma (PDAC), Colorectal Cancer (CRC), Non-Small Cell Lung Cancer (NSCLC)
Leveraging the Emergency Department (LEAD) Study
Recruiting
This is a pilot Type 1 Hybrid Effectiveness-Implementation Trial. The study will first examine reach in a non-traditional setting (the Emergency Department - ED) that uses an Electronic Health Record (EHR)-embedded Social Determinants of Health (SDoH) screening tool to identify lung screening-eligible patients for a tailored intervention to increase lung screening uptake. Reach is defined as the absolute number, proportion, and representativeness of individuals targeted for lung screening knowle... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
08/18/2025
Locations: Ocean Medical Center, Brick, New Jersey +9 locations
Conditions: Lung Cancer
Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor
Recruiting
The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are: 1. Does the use of 5% dextrose and Lactated Ringers lead to a shorter labor than the use of just Lactated Ringers? 2. Does the use of 5% dextrose and Lactated Ringers increase the risk o... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia +1 locations
Conditions: Induced Labor
Mindfulness, Optimism, and Resilience for Perinatal Health and Equity Study
Recruiting
Dispositional optimism (the general assumption that more good things than bad will occur across various life domains) has been tied to improved somatic and mental health outcomes. Dispositional optimism is malleable, although prior interventions have been time and resource intensive and thus are not well-tailored to the peripartum period. The purpose of this pilot study is to evaluate the feasibility and acceptability of a pregnancy-oriented mindfulness phone application (Expectful) versus stand... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Obstetrics and Gynecology Care Center, Providence, Rhode Island +1 locations
Conditions: Postpartum Psychiatric Disorders
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Participants With Immune-Mediated Diseases (Ntrust-2)
Recruiting
This is an open-label, multi-center, multi-cohort, non-randomized Phase 1 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with Immune-Mediated Diseases (IMD) including systemic sclerosis \[SSc\], idiopathic inflammatory myopathies \[IIM\], and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis \[AAV\].
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/18/2025
Locations: Nkarta Investigational Site, Orange, California +9 locations
Conditions: Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease
Recruiting
The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Participants will be randomly assigned to a 12-week course of the study drug, dapagliflozin 10mg, or placebo. Blood flow in the heart will be assessed using stress cardiac magnetic resonance imaging at basel... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
08/18/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Myocardial Ischemia
The INSPIRE-Lung Study
Recruiting
LungTalk and leveraging Facebook-targeted Advertisement (FBTA) addresses the call to develop and test multi-level, cancer communication interventions using innovative methods and designs. The study's long term goal is to increase lung cancer screening uptake among appropriate, high-risk individuals nationwide.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
08/18/2025
Locations: Hackensack Meridian Health - Center for Discovery and Innovation, Nutley, New Jersey
Conditions: Lung Cancer
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
Recruiting
This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Honor Health, Scottsdale, Arizona +66 locations
Conditions: Metastatic Uveal Melanoma
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
Recruiting
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/18/2025
Locations: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts +1 locations
Conditions: Aging, Mobility Disability
Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement
Recruiting
The purpose of this study is to evaluate the effectiveness, feasibility, and safety of mandibular advancement devices (MAD) for treating severe obstructive sleep apnea (OSA) in patients who are CPAP intolerant and have failed hypoglossal nerve stimulation (HGNS).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/18/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Obstructive Sleep Apnea
Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
Recruiting
This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, low and high). Target dose: 150 inspirations t... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
08/18/2025
Locations: Duke Health Center Creekstone, Durham, North Carolina +1 locations
Conditions: Asthma in Children, Obesity, Pediatric Obesity, Pediatric Asthma