Imaging the Pathogenesis of Cerebral Small Vessel Disease
NCT05703386
Recruiting
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes
Register for Updates
A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer
NCT05726292
Recruiting
Researchers conducting this study hope to learn about the safety and effectiveness of combining two study drugs, relacorilant and enzalutamide, plus androgen deprivation therapy (ADT), also known as hormone therapy. This study is for individuals who have been diagnosed with advanced, high-risk prostate cancer and standard therapies available to treat your disease have not been effective. Participation in this research will last about 3 years and 9 months.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: University of Chicago Comprehensive Cancer Center, Chicago, Illinois +1 locations
Conditions: Prostate Cancer, Prostate Adenocarcinoma
Register for Updates
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
NCT05728697
Recruiting
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, which have traditionally had less accurate results in this population. The main questions it aims to answer are: * Determine accuracy of EUS-SWE for liver fibrosis screening compared to other non-inva... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity
Register for Updates
SHAPE Test for Preoperative Risk Stratification
NCT05743673
Recruiting
Primary Objective Characterizing precise functional capacity in surgical patients is critical for risk stratification and identification of patients at high risk for perioperative complications. The primary objective for the study is to evaluate the feasibility of effective subject recruitment of an FDA-approved simplified cardiopulmonary exercise testing apparatus in adults \>60 years old prior to moderate to high-risk surgery. In addition, by development of a validation cohort of older adults,... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/05/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Perioperative/Postoperative Complications, Aerobic Capacity
Register for Updates
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
NCT05780814
Recruiting
The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for insomnia (CBT-I) prior to behavioral weight loss (CBT-I+BWL) is superior to a sleep education control (EDU) condition followed by behavioral weight loss (EDU+BWL). The investigators will measure outcomes at baseline, 8 weeks (after completing CBT-I or EDU and prior to BWL)... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Sibley Memorial Hospital, Washington, District of Columbia +3 locations
Conditions: Breast Cancer, Insomnia, Weight Gain
Register for Updates
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
NCT05786417
Recruiting
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/05/2025
Locations: Yale School of Medicine, New Haven, Connecticut +8 locations
Conditions: Angina, Stable Ischemic Heart Disease
Register for Updates
Telehealth Treatment for Opioid Use Disorders
NCT05832879
Recruiting
This study aims to use an Opioid Use Disorder (OUD) Telehealth Platform to reduce overdose events. This telehealth platform will be pilot tested to evaluate its preliminary efficacy in terms of motivating engagement in medications for OUD (MOUD), as well as its feasibility, acceptability and satisfaction to both first responders/providers and participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Opioid Use Disorder
Register for Updates
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487
Recruiting
This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate safety and efficacy of the Cordella PA Sensor System in NYHA Class II HF patients, where patients have daily access to PAP data. * Treatment Arm (Group 1) * Active Control Arm (Group 2) * Crossover Arm... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: St. Joseph's Hospital and Medical Center, Phoenix, Arizona +45 locations
Conditions: Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
Register for Updates
Optimization Post-TAVR to IMprove Activity Levels (OPTIMAL Study)
NCT06106451
Recruiting
In this study, the investigators will evaluate the feasibility and potential efficacy of programs to improve functional outcomes after minimally-invasive transcatheter aortic valve replacement (TAVR). The investigators will examine the potential efficacy of (a) a motivation interviewing program, and (b) a home-based physical activity + motivational interviewing program, compared to (c) usual care + enhanced education in patients post-TAVR procedure.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/05/2025
Locations: The Johns Hopkins University, Baltimore, Maryland
Conditions: Aortic Valve Disease, Aortic Valve Replacement
Register for Updates
The SUGAR Study; SBRT and Relugolix) for Prostate Cancer
NCT06111781
Recruiting
The goal of this clinical trial is to measure the toxicity and effectiveness of the following treatments for cFIR/cgUIR prostate cancer patients. Stereotactic body radiotherapy (SBRT) alone or Stereotactic body radiotherapy (SBRT) combined with Ultrashort GNRH Antagonist called Relugolix (an oral drug). Treatments will be randomly assigned to study patients. The main questions it aims to answer are the following: 1. Whether the proportion of men who undergo SUGAR have a superior rate of attai... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Yale Cancer Center, New Haven, Connecticut +1 locations
Conditions: Prostate Cancer
Register for Updates
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
NCT06132035
Recruiting
This will be a randomized, comparative, parallel, clinical study to assess initial safety and tolerability of CG-P5 peptide eye drops compared to placebo in patients diagnosed with age-related wet macular degeneration
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/05/2025
Locations: CBCC Global Research Site:005, Manchester, Connecticut +6 locations
Conditions: Age-related Wet Macular Degeneration
Register for Updates
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults with PKP2 Mutation-associated ARVC
NCT06228924
Recruiting
This first-in-human study is designed to evaluate the safety, and preliminary efficacy (PD) of TN-401 gene therapy in adult patients with symptomatic PKP2 mutation-associated ARVC.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/05/2025
Locations: University of California San Francisco, San Francisco, California +6 locations
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy
Register for Updates