Craniomaxillofacial and Upper Extremity Allotransplantation
Recruiting
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional reconstructive surgical strategies and prosthetic devices.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
01/30/2025
Locations: NYU Langone Health, New York, New York
Conditions: Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries, Facial Injuries, Facial Deformity
Bupropion for the Prevention of Postpartum Smoking Relapse
Recruiting
This two-arm, double-blind, placebo-controlled randomized clinical trial will enroll pregnant women who quit smoking after learning they were pregnant and are motivated to stay abstinent postpartum. Participants will be randomized to receive extended-release bupropion (active 300mg or placebo once daily beginning 4 to 10 days postpartum to 12 weeks post-randomization). All participants will complete the same data collection procedures (e.g., biological sample collection for hormone and cotinine... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/30/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Postpartum Smoking Relapse
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. The purpose of this registry is to assess the long term outcomes of patients with SMA in the c... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: Phoenix Children's Hospital, Phoenix, Arizona +98 locations
Conditions: Spinal Muscular Atrophy (SMA)
Implications of the Human Microbiota for Health and Disease
Recruiting
The purpose of this study is to advance the understanding of human health and disease as it relates to environmental factors that may affect intestinal and non-intestinal microbiota.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Human Microbiota
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old
Recruiting
This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine (CPX-351) works in treating patients with secondary acute myeloid leukemia who are younger than 60 years old. Drugs used in chemotherapy, such as CPX-351, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
01/30/2025
Locations: University of Nebraska Medical Center, Omaha, Nebraska +3 locations
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia With Myelodysplasia-Related Changes, Secondary Acute Myeloid Leukemia, Therapy-Related Acute Myeloid Leukemia
Prevent Cancer- Greenville
Recruiting
Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. If subjects are found to be at high risk for developing a disease, they will be sent to a healthcare provider for further care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Prisma Health-Upstate, Greenville, South Carolina
Conditions: Cancer, High-Risk Cancer
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
Recruiting
This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in heart structure in patients with congenital heart disease (CHD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Tetralogy of Fallot, Congenital Heart Disease
Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions
Recruiting
The purpose of study is to evaluate whether home visit programs are an effective method for HTN and T2DM management as compared to standard of care clinic visits.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/30/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Hypertension, Type 2 Diabetes
A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
Recruiting
The researchers are doing this study to find out whether deferoxamine (DFO) given intrathecally (directly into the CSF) is a safe treatment for people with leptomeningeal metastasis from solid tumor cancer. The researchers will test different doses of DFO to find the highest dose that causes few or mild side effects. When the dose is found, they will test it in future participants to see whether DFO is a safe and effective treatment for people with leptomeningeal metastasis from solid tumor mali... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Leptomeningeal Metastases
Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH)
Recruiting
The overall goal of this study is to promote awareness of Familial Hypercholesterolemia (FH). The investigators aim to enroll patients with suspected FH into the study and will randomize them to receive usual care or motivational interview. Primary study outcomes include knowledge of FH, as well as clinical and patient-reported outcomes. This study aims to promote optimal disease management and improve outcomes of FH patients.
Gender:
ALL
Ages:
Between 2 years and 75 years
Trial Updated:
01/30/2025
Locations: Aspirus St. Luke's Hospital, Duluth, Minnesota +1 locations
Conditions: Familial Hypercholesterolemia, Cholesterol, Elevated, Genetic Disease
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
Recruiting
This is Phase 1 dose finding trial with potential dose expansion to evaluate the safety, toxicity, recommended phase 2 dose (RP2D), and maximum tolerated dose (MTD) of Neratinib plus TDxD using a standard 3+3 dose escalation design in patients with metastatic or unresectable gastro-esophageal cancer that are HER2-overexpressing (IHC 3+ or IHC2+/ISH+) and any other gastrointestinal cancer with HER2 expression with IHC3+. Patients must have progressed or been intolerant of at least one prior line... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Stanford Cancer Center, Palo Alto, California +2 locations
Conditions: Gastric Cancer, Gastrointestinal Cancer, HER2 Gene Mutation
Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma
Recruiting
This is a single arm open-label multicenter phase I/II investigation of combination lenalidomide/Tafasitamab in patients with relapsed central nervous system (CNS) lymphoma. This is the first study to examine a naked anti-CD19 monoclonal antibody in relapsed CNS lymphoma patients as well as the combination of anti-CD19 antibody plus an Immunomodulatory imide drugs (IMiDs) in CNS lymphomas. This study will also test the novel hypothesis that Tafasitamab enhances blood-brain barrier permeability,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: CNS Lymphoma, Primary Central Nervous System Lymphoma, Secondary Central Nervous System Lymphoma