Phase 2b Safety and Efficacy Study of CGB-500 Topical Ointment with 0.5% and 1% Tofacitnib for Treatment of Atopic Dermatitis
Recruiting
The goal of this clinical trial is to learn if CGB-500 works to treat atopic dermatitis in participants ages 12 and older. The goal is also to learn about the safety of CGB-500. The main questions it aims to answer are: Does CGB-500 improve atopic dermatitis by decreasing the area affected and the severity of the lesions? What medical problems do participants have when taking CGB500? Researchers will compare CGB-500 to a placebo (a look-alike substance that contains no drug) to see if CGB-500 w... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
01/30/2025
Locations: Center for Dermatology Clinical Research Inc., Fremont, California +15 locations
Conditions: Atopic Dermatitis (AD)
The ROAM Research Study Therapy (LTOT) Version
Recruiting
The purpose of this research is to test a device being developed that can see how patients use oxygen therapy over a long period of time. This study will focus on developing a new display part called ROAM module which will be attached to your oxygen source. The display will provide easily-accessible information that can show how you interact with your supplies and the oxygen machine automatically without connecting the oxygen source to the internet or other devices.
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Pulmonary Disease, Chronic Obstructive
Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery
Recruiting
Evaluate voice and swallowing outcomes post operatively.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
01/29/2025
Locations: UAB, Birmingham, Alabama
Conditions: Dysphagia, Dysphonia
DS-Connect®: The Down Syndrome Registry
Recruiting
The goal of this study is to develop a registry for Down syndrome (DS) to facilitate research participation by individuals with Down syndrome. DS-Connect® is an online survey tool designed to collect demographic data and health information from individuals with DS. It is open to all people with Down syndrome. The purposes of DS-Connect® are: 1. To identify the various phenotypic manifestations of DS. 2. To identify individuals with DS who may be eligible for research studies or new clinical t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/29/2025
Locations: Linda Crnic Institute for Down Syndrome, Aurora, Colorado
Conditions: Down Syndrome
Tumor-Associated Antigen-Specific Cytotoxic T-Lymphocytes for Multiple Myeloma
Recruiting
This study is for patients that have a cancer called Multiple Myeloma, monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SM). MGUS and SM have tumor cells that possess nearly identical properties to the cancer cells seen in patients with multiple myeloma. The investigators would like to target proteins that are expressed by these cells using the patient's own immune cells known as T lymphocytes.This research study uses special immune system cells called tumor asso... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Harris Health Ben Taub Hospital, Houston, Texas +2 locations
Conditions: Multiple Myeloma
Glowing and Expecting Follow Up
Recruiting
This study will help us learn more about how a mother's health during pregnancy may influence her child's growth and development later in life.
Gender:
ALL
Ages:
Between 5 years and 14 years
Trial Updated:
01/29/2025
Locations: Arkansas Children's Nutrition Center, Little Rock, Arkansas
Conditions: Healthy
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
Recruiting
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.
Gender:
MALE
Ages:
45 years and above
Trial Updated:
01/29/2025
Locations: Georgia Cancer Center at Augusta University, Augusta, Georgia +53 locations
Conditions: Prostate Cancer, Cardiovascular Disease
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
Recruiting
Prospective, controlled, multicenter clinical investigation with four trial cohorts: Randomized, Non-repairable, Severe Mitral Annular Calcification (MAC) and Severe Mitral Annular Calcification Continued Access Protocol (MAC CAP). Subjects in the Randomized cohort will be randomized in a 1:1 ratio to the trial device or to the MitraClip system. Subjects in the Non-repairable, Severe MAC, and Severe MAC CAP cohorts will receive the trial device. The objective of the Clinical Trial to Evaluate t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Princeton Baptist Medical Center, Birmingham, Alabama +79 locations
Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
Recruiting
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes. This tool has been utilized to accurately predict embryo quality here at Cornell. Utilizing this tool to assess objective clinical findings and predict outcomes of assisted reproductive techniques is sought, with the ultimate goal of an automated tool to reduce implicit physician bias. Within this goal, using this tool to objectively and acc... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
01/29/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Infertility, in Vitro Fertilization (IVF), ART
Persona Revision Knee System Outcomes
Recruiting
The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with prospective follow-up.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Advanced Orthopaedic Specialists, Fayetteville, Arkansas +15 locations
Conditions: Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
Teen Sleep and Light Study
Recruiting
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents. Early school start times, however, force teenagers to awaken earlier than their spontaneous wake time and the opportunity for sleep shortens. Chronic circadian misalignment and sleep restriction are at their peak during late adolescence, and are associated with various negative outcomes. Morning bright light exposure from light boxes can shift rhythms earlier (p... Read More
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
01/29/2025
Locations: Rush University Medical Center, Biological Rhythms Research Laboratory, Chicago, Illinois
Conditions: Chronobiology, Light, Sleep, Circadian Rhythm, Adolescence
Evaluation of the PE Coach Mobile Application Among Veterans With PTSD
Recruiting
Thousands of mental health mobile applications (apps) are available but limited research has been conducted on their effectiveness. VA has been a leader in mental health mobile app development and must research whether these apps work, and if so, how? PE Coach is a well-designed treatment companion app to one of the most researched, efficacious psychotherapies for PTSD (prolonged exposure), a treatment that has been broadly disseminated throughout VA mental health clinics. Research suggests that... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/29/2025
Locations: VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington
Conditions: Posttraumatic Stress Disorder