Online Interplay Between Deciding and Acting with Mild Cognitive Impairment
Recruiting
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitatio... Read More
Gender:
ALL
Ages:
Between 45 years and 90 years
Trial Updated:
01/29/2025
Locations: University of Delaware, Newark, Delaware
Conditions: Mild Cognitive Impairment
AlloMend Acellular Dermal Matrix Allograft in Pre-Pectoral Breast Reconstruction
Recruiting
This is a single-center, retrospective study which will be used to describe and evaluate the effectiveness of AlloMend® Acellular Dermal Matrix allograft for patients that have undergone Pre-Pectoral Breast Reconstruction surgery following a single or double mastectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Alan H. Chen Surgical Associates, PC, Joliet, Illinois
Conditions: Pre-Pectoral Breast Reconstruction Following Single or Double Mastectomy
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects with Hepatic Impairment and in Healthy Subjects with Normal Hepatic Function
Recruiting
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with moderate hepatic impairment and subjects without hepatic impairment, matched for age, body weight and, to the extent possible, for gender. The primary purpose of this study is to characterize the effect of hepatic impairment on the plasma pharmacokinetics of ALG-097558 following administration of multiple, twice daily (Q12H) oral (PO) doses.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/29/2025
Locations: University of Miami, Miami, Florida +1 locations
Conditions: COVID-19
An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis
Recruiting
The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal scaling and root planing for improving the treatment of periodontal disease.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
01/29/2025
Locations: 805 Dentistry, Thousand Oaks, California +1 locations
Conditions: Periodontal Diseases, Periodontitis, Gum Disease
Regulating Emotions Like An eXpert Among Adolescents With ADHD
Recruiting
This study consists of a randomized controlled trial assessing the acceptability, feasibility, and efficacy of the RELAX (Regulating Emotions Like An eXpert) Intervention. Following randomization, 30 families will receive the RELAX intervention and 30 families will receive psychoeducational materials as part of a control condition. Additionally, 10 families from the RELAX condition will participate in a pilot study and focus groups to give feedback on developed smartphone apps to support skill u... Read More
Gender:
ALL
Ages:
Between 11 years and 16 years
Trial Updated:
01/29/2025
Locations: Child Study Center, Blacksburg, Virginia
Conditions: RELAX Telehealth Intervention, Psychoeducational Waitlist Control, EMI Smartphone App Pilot
Knee Injections for Obese Patients with Knee Arthritis
Recruiting
The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
01/29/2025
Locations: Mayo Clinic in Florida, Jacksonville, Florida
Conditions: Osteoarthritis of Knee
Refractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations
Recruiting
The purpose of this study is to evaluate and compare the potential refractive outcomes using the Argos 1.5 biometer in the surgical planning for cataract extraction to that obtained from IOLMaster 700. Both devices are used as standard of care in surgical planning optimization for patients undergoing cataract surgery.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/29/2025
Locations: The Eye Institute of Utah, Salt Lake City, Utah
Conditions: Cataract
Predicting Response to Neoadjuvant Endocrine Therapy (Neo-PREDICT)
Recruiting
The goal of this clinical trial is to determine how the duration of hormone blocking (endocrine) therapy given prior to surgery (called "neoadjuvant" treatment) affects breast cancer. The main questions the trial aims is answer are: 1. How breast cancer responds to endocrine therapy given prior to surgery? 2. To predict tumor pre-operative endocrine prognostic index (PEPI) score for subjects enrolled in cohort B or C Participants with early-stage breast cancer (Stage I-III) who are eligible fo... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/29/2025
Locations: George Washington-Medical Faculty Associates, Washington, District of Columbia
Conditions: Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Carcinoma, Breast
A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer
Recruiting
This study will test whether valemetostat in combination with atezolizumab is a safe treatment that causes few or mild side effects in people with extensive-stage small cell lung cancer (SCLC). The researchers will test different doses of valemetostat to find the highest dose that causes few or mild side effects in participants. After the dose is found, researchers will test it in a new group of participants to learn more about the safety of the study treatment and see if it is an effective trea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Extensive-stage Small-cell Lung Cancer
Flu Infection at UPHS
Recruiting
Cellular and humoral immune responses in individuals with active influenza infection will be assessed. Each year, up to 50 participants will be enrolled. The investigators hypothesize that influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Influenza Human
NIMH Clinical Pathway in Rural Appalachian School-based Health Clinics
Recruiting
This study will adapt and evaluate an evidence-based suicide risk screening and follow-up program in two school-based health centers in West Virginia. The suicide screening program is titled the "NIMH Clinical Pathway" and provides tools and procedures for routinely screening adolescents for suicide risk, completing risk assessments, safety planning, lethal means restriction, follow-up referrals, and other disposition planning as appropriate. Investigators aim to do the following: 1. Gather fo... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
01/29/2025
Locations: West Virginia University, Morgantown, West Virginia
Conditions: Suicide Prevention, Suicide
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2025
Locations: Local Institution, Birmingham, Alabama +197 locations
Conditions: Multiple Myeloma