The Pericapsular Nerve Block in Total Hip Arthroplasty
Recruiting
In order to continue progressing towards outpatient total hip arthroplasty (THA), methods to adequately manage postoperative pain is of paramount importance. The purpose of this study is to quantify the effectiveness of the pericapsular nerve block in total hip arthroplasty in comparison to the fascia iliaca nerve block.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/20/2025
Locations: Sinai Hospital of Baltimore, Baltimore, Maryland
Conditions: Hip Osteoarthritis, Hip Arthropathy
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
Recruiting
Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives. Theoretically, achievement of normal knee motion using a medial pivot design in total knee replacements can be recreated in comparison to single radius designs, which could lead to an improvement in post-surgical outcomes and satisfaction with the procedure. The aim of this study is to compare two types of implant designs (medial pivo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/20/2025
Locations: Sinai Hospital of Baltimore, Baltimore, Maryland
Conditions: Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left, Osteoarthritis Knee Right, Knee Pain Chronic, Knee Disease, Arthropathy of Knee Joint
Grocery Delivery and Healthy Weight Gain Among Low-income Pregnant Young Women
Recruiting
This project will increase knowledge about how a simple intervention, grocery delivery, impacts weight gain and diet among low-income pregnant young women. Results can then be used to support other pregnant young women.
Gender:
FEMALE
Ages:
Between 14 years and 26 years
Trial Updated:
01/20/2025
Locations: The University of Michigan, Ann Arbor, Michigan
Conditions: Pregnancy, Weight Gain
Switch Maintenance in Pancreatic
Recruiting
This study is being done to test the safety and effectiveness of combining domvanalimab (AB154), zimberelimab (AB122), and APX005M with pancreatic cancer that has spread to other parts of body. This research study involves immunotherapy. Immunotherapy triggers the body's immune system to fight cancer cells. The names of the study drugs involved in this study are: * Domvanalimab (also known as AB154) * Zimberelimab (also known as AB122) * APX005M
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adenocarcinoma of the Pancreas, Squamous Cell Carcinoma of Pancreas, Adenosquamous Carcinoma of the Pancreas
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
Recruiting
The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 220 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: The University of Alabama at Birmingham, Birmingham, Alabama +206 locations
Conditions: Endometrial Cancer
3D Printed Personalized Ostomy Appliance
Recruiting
The goal of this clinical trial is to learn about the effectiveness of using a 3D scan for a personal ostomy appliance. The main question it aims to answer is: • Whether or not a 3D scan of a stoma reduces leakages and improves patient quality of life in regard to using a personalized ostomy appliance. Participants will * Spend 2 weeks with their standard of care ostomy appliance * Spend 2 weeks with their personalized ostomy appliance made from a 3D scan * Participate in daily surveys and we... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/20/2025
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: 3D Printing, Ostomy, Leakage
The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction
Recruiting
The purpose of the research is to investigate the effect of preoperative Cryoneurolysis of the knee on postoperative pain management in patients undergoing autograft anterior cruciate ligament (ACL) reconstruction (a surgical procedure that makes a new ACL using the patient's own tendon). Cryoneurolysis is an approved process of applying extreme cold temperatures to targeted nerves in order to decrease or eliminate pain. . If you take part in the research, you will be randomly assigned (assigned... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
01/20/2025
Locations: Virtua Orthopedics Burlington, Burlington, New Jersey +1 locations
Conditions: ACL Repair
Testicular Tissue Cryopreservation in Children
Recruiting
This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential.
Gender:
MALE
Ages:
Between 0 years and 17 years
Trial Updated:
01/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cancer, Cancer-Related Condition, Infertility
Reduction of Myopotential Interference With Smart Pass in S-ICD Patients
Recruiting
This study is enrolling participants who are already implanted with a S-ICD device ( subcutaneous ICD), and are undergoing a routine outpatient clinic follow up appointment to have their S-ICD checked. The aim of the study is to see if a feature in the device can recognize muscle movement and differentiate movement from irregular heart signals. The study involves doing some simple arm exercises while collecting device data, both with this feature turn on and then with it turned off. Participants... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Subcutaneous ICD, Myopotential Interference
EC-104 Intravitreal Implant for the Treatment of Diabetic Macular Edema
Recruiting
This is a prospective, randomized, subject- and evaluator-masked, Phase 2, multicenter study comparing the safety and efficacy of EC-104-6M high-dose (fluocinolone acetonide \[FA\] 0.14 mg) implant and EC-104-4M low-dose (FA 0.092 mg) implant to Ozurdex® (dexamethasone intravitreal (IVT) implant, 0.7 mg) in subjects with diabetic retinopathy (DR) and center-involving diabetic macular edema (DME), with prior suboptimal clinical response to IVT anti-VEGF therapy who have been previously treated wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2025
Locations: Retina Associates of Florida, LLC, Tampa, Florida
Conditions: Diabetic Macular Edema
Novel Pilot Study to Treat Symptoms of IBS with Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator
Recruiting
The purpose of this research is to study the added benefit of treating IBS symptoms with a medication called mirtazapine in treating IBS symptoms when paired with a low-FODMAP diet compared to a low-FODMAP diet alone. FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. These are short-chain carbohydrates that can cause digestive distress in some people. You have been asked to take part in this research because you have symptoms of diarrhea-predominant ir... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/19/2025
Locations: Mayo Clinic, Jacksonville, Florida
Conditions: IBS - Irritable Bowel Syndrome, Diarrhea
Diphencyprone Plus Immune Checkpoint Inhibition in the Treatment of Cutaneous Metastases
Recruiting
This is a phase I, open label study employing diphencyprone (DPCP) to characterize gene expression changes of various immune cell and tumor markers in cutaneous metastases treated with topical DPCP twice weekly for 12 weeks in combination with PD-1 or PD-L1 immune checkpoint inhibition (ICI), compared to pre-treatment cutaneous metastases and to describe the adverse events associated with DPCP when administered topically twice weekly for 12 weeks in combination with PD-1 or PD-L1 ICI.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/18/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Cutaneous Metastases