VCOM Pain Free Research
NCT06533345
Recruiting
Studies estimate that 30% of people worldwide experience chronic pain. The mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue damage and repair; or nociplastic, dysfunctional offenders, such as fibromyalgia. The type of pain experienced influences diagnostic and treatment choice. In theory, there's a significant blending of these pain types within individuals and across patients, leading many s... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
10/02/2024
Locations: Edward Via College of Osteopathic Medicine-Auburn, Auburn, Alabama
Conditions: Chronic Pain
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Cortical Recording and Stimulating Array Brain-Machine Interface
NCT01894802
Recruiting
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
10/02/2024
Locations: University of Chicago, Chicago, Illinois +1 locations
Conditions: Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury, Above Elbow Amputation
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Therapeutic Omegas for Triglyceride Suppression
NCT04349475
Recruiting
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood. Your body converts extra calories into triglycerides to be stored and used later for energy. It is normal for triglyceride levels to go up during pregnancy however some women have levels that are \~30-40% higher than normal when they reach their third trimester of pregnancy. Having high triglycerides in pregnancy may be related t... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Colorado/Anschutz Medical Campus, Aurora, Colorado +1 locations
Conditions: Pregnancy
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Integrated Supportive and Palliative Care for Older Adults in the ICU
NCT04921631
Recruiting
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or survive with substantial impairments. These patients often die with distressing symptoms and may receive more invasive, life-prolonging treatment than they would choose for themselves. Moreover, their family members acting as surrogate decision makers often experience lasting... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/02/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Critical Illness
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Options for Pain Management Using Nonpharmacological Strategies
NCT05563792
Recruiting
The purpose of this study is to help Veterans learn about different ways they can manage chronic pain that do not involve medications. Veterans will work with a coach to explore the Veterans' values and goals and how different non-medication approaches may fit into these values and goals.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana
Conditions: Pain
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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864
Recruiting
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
10/02/2024
Locations: Research Site, Birmingham, Alabama +254 locations
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
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Kaiser Permanente VACCination Improvement with Nudge-based CardiovAscular Targeted Engagement
NCT06571747
Recruiting
In randomized clinical trials and observational studies, influenza vaccination is effective in reducing influenza-related illness and hospitalizations and potentially cardiovascular (CV) events and mortality in select populations. However, the potential population-level benefit of influenza vaccination is limited by its uptake. Novel implementation strategies to improve vaccination uptake are needed. KP VACCINATE is a multicenter, sequential, individual-level randomized controlled implementatio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: Kaiser Permanente Northern California, Pleasanton, California +1 locations
Conditions: Cardiovascular Diseases, Influenza, Behavior, Social
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Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
NCT02703207
Recruiting
Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction. The investigators sought to investigate whether these two highly prevalent diseases, that often co-exist as the 'Overlap Syndrome', combine to enhance cognitive impairment in the elderly Veteran population. Thus, the investigators will study whether elderly patients with Overlap syndrome... Read More
Gender:
ALL
Ages:
Between 60 years and 89 years
Trial Updated:
10/02/2024
Locations: John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan
Conditions: Obstructive Sleep Apnea, OSA COPD Overlap Syndrome
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Pembrolizumab With or Without Axitinib for Treatment of Locally Advanced or Metastatic Clear Cell Kidney Cancer in Patients Undergoing Surgery
NCT04370509
Recruiting
This phase II trial studies how well pembrolizumab with or without standard of care axitinib works in treating patients with clear cell kidney cancer that has spread to nearby tissues or lymph nodes (locally advanced) or other places in the body (metastatic) who are undergoing surgery. Pembrolizumab is an antibody that is designed to bind to and block the activity of PD-1, a molecule in the body that may be responsible for inhibiting the body's immune response against cancer cells. Axitinib is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Metastatic Clear Cell Renal Cell Carcinoma, Recurrent Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Clear Cell Renal Cell Carcinoma
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Study of ADI-PEG 20, Venetoclax and Azacitidine in Acute Myeloid Leukemia
NCT05001828
Recruiting
Pegylated arginine deiminase (ADI-PEG 20) will be combined with venetoclax and azacitidine for treatment of subjects with previously treated or untreated with high risk factor acute myeloid leukemia (AML). Venetoclax and azacitidine are front-line therapy for such patients, and ADI-PEG 20 will be added to this regimen in a phase IA/B study.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/02/2024
Locations: Sylvester Comprehensive Cancer Center, Miami, Florida +3 locations
Conditions: Acute Myeloid Leukemia, Adult
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A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection
NCT05582694
Recruiting
Background: People with HIV usually take a combination of 2 or more anti-HIV drugs daily to help manage their infection. Sometimes, however, HIV becomes resistant to these drugs, and the infection cannot be treated. Untreated HIV infection can make people more vulnerable to other infections as well as some cancers. Better treatments are needed for people with drug-resistant HIV. Objective: To see if a study drug (UB-421) is effective in people with drug-resistant HIV. Eligibility: People ag... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Multi-Drug Resistant Hiv-1 Infection, HIV-1 Infection
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CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
NCT06133842
Recruiting
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60 undergoing major non-cardiac surgery. The main question\[s\] it aims to answer are: * Is there a way to tailor the blood pressure to be maintained in such patients during surgery for optimal brain health using non-invasive monitors that check the brains electrical activit... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/02/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities, Intraoperative Hypotension, Cerebral Hypoperfusion
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