A Study of HARMONIC 700 Shears With Advanced Hemostasis in Pediatric and Adult Surgical Procedures
NCT06608485
Recruiting
The main purpose of this study is to demonstrate acceptable performance and assess safety of the HARMONIC 700 Shears device in a post-market setting when used per the instructions for use in pediatric and adult surgical procedures.
Gender:
ALL
Ages:
110 years and below
Trial Updated:
05/22/2025
Locations: Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana +7 locations
Conditions: Pediatric Surgical Procedures, Adult Surgical Procedures, Adult Gynecological Procedures, Adult Urological Procedures, Adult Thoracic Procedures
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A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)
NCT06646289
Recruiting
The purpose of this study is to assess the safety and tolerability of subretinal delivery of Adeno-associated Virus Vector (AAV5 hRKp.RPGR) gene therapy in adults and children with X-linked retinitis pigmentosa.
Gender:
MALE
Ages:
5 years and above
Trial Updated:
05/22/2025
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts +1 locations
Conditions: X-Linked Retinitis Pigmentosa
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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574
Recruiting
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/22/2025
Locations: Advanced Cardiovascular, LLC, Alexander City, Alabama +32 locations
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction
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Olutasidenib, Venetoclax, and Azacitidine in IDH1 Mutated Newly Diagnosed Acute Myeloid Leukemia Patients Eligible for Intensive Induction Chemotherapy
NCT06782542
Recruiting
The purpose of this study is as follows: 1. Determine whether people receiving the combination treatment of olutasidenib, venetoclax, and azacitidine have the same, more, or fewer side effects compared to the usual chemotherapy treatment that people with this condition receive. 2. Determine how well the combination treatment of olutasidenib, venetoclax, and azacitidine works compared to the usual chemotherapy treatment that people with this condition receive.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2025
Locations: University of Miami, Miami, Florida
Conditions: Acute Myeloid Leukemia, IDH1 Mutation
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A Pilot Study of Efgartigimod for Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)
NCT06831058
Recruiting
Immune-mediated Thrombotic thrombocytopenic purpura (iTTP) is a rare, autoimmune disorder characterized by life-threatening episodes of thrombocytopenia, microangiopathic hemolytic anemia and organ damage. Patients have an unpredictable course punctuated by relapses associated with autoantibody-mediated (primarily IgG) depletion of ADAMTS13, a key regulator of coagulation. ADAMTS13 deficiency during remission has been associated with increased risk of relapse, but also, and potentially more deva... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Immune-mediated Thrombotic Thrombocytopenic Purpura
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A Study to Assess the Pharmacokinetics and Safety of Bimekizumab in Children and Adolescents With Moderate to Severe Hidradenitis Suppurativa
NCT06921850
Recruiting
The purpose of the study is to assess the PK of bimekizumab following subcutaneous (sc) administration in study participants with moderate to severe hidradenitis suppurativa (HS)
Gender:
ALL
Ages:
Between 9 years and 17 years
Trial Updated:
05/22/2025
Locations: Hs0006 50708, Roseville, California +5 locations
Conditions: Hidradenitis Suppurativa
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Radicle Health 24: A Study of Health and Wellness Products on Overall Health
NCT06989710
Recruiting
A randomized, double-blind, placebo-controlled direct-to-consumer study of health and wellness products on overall health
Gender:
ALL
Ages:
Between 21 years and 105 years
Trial Updated:
05/22/2025
Locations: Radicle Science, Inc, Del Mar, California
Conditions: Overall Health
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Training Protocol on the Natural History of Tuberculosis
NCT01212003
Recruiting
Background: - Tuberculosis (TB) is an infectious disease that affects numerous people worldwide. Researchers are interested in actively recruiting individuals with TB for research and treatment studies. Objectives: - To collect blood and other samples to study the natural history of tuberculosis. Eligibility: - Individuals 2 years of age and older who have either active or latent tuberculosis. Design: * Latent TB patients: Participants will have a single study visit with a physical examin... Read More
Gender:
ALL
Ages:
Between 2 years and 100 years
Trial Updated:
05/22/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Mycobacterium Infections, Tuberculosis, Multidrug-Resistant, Latent Tuberculosis, Tuberculosis, Extensively Drug-Resistant Tuberculosis
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Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
NCT02429557
Recruiting
Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tolerance in these patients, and to compare them with those of the standard of care midodrine. The investigators will test the hypothesis that abdominal compression will blunt the exaggerated fall in str... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/22/2025
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Orthostatic Hypotension, Pure Autonomic Failure, Multiple System Atrophy, Autonomic Failure
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Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia
NCT02981628
Recruiting
This phase II trial studies how well inotuzumab ozogamicin works in treating younger patients with B-lymphoblastic lymphoma or CD22 positive B acute lymphoblastic leukemia that has come back (relapsed) or does not respond to treatment (refractory). Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a toxic agent called ozogamicin. Inotuzumab attaches to CD22 positive cancer cells in a targeted way and delivers ozogamicin to kill them.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
05/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +155 locations
Conditions: Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma, Refractory B Acute Lymphoblastic Leukemia, Refractory B Lymphoblastic Lymphoma
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Cardiovascular Disease Risk in Women With Endometriosis
NCT03746535
Recruiting
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/22/2025
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Endometriosis
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NOLA (NeuWave Observational Liver Ablation) Registry
NCT04107766
Recruiting
This is a multicenter, observational registry that follows patients for a total of 5 years from the date of the first liver ablation procedure with the NEUWAVE Microwave Ablation System.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
05/22/2025
Locations: Loma Linda University Medical Center, Loma Linda, California +29 locations
Conditions: Cancer of the Liver, Liver Cancer, Neoplasms, Liver
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