Study of Inupadenant (EOS100850) with Chemotherapy As Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer
NCT05403385
Recruiting
The study will first determine the optimal dose of inupadenant to be given in combination with carboplatin and pemetrexed to patients that progressed after receiving first line anti-PD(L)1 treatment for locally advanced or metastatic non-small cell lung cancer. The efficacy and safety of the combination is then compared to standard of care carboplatin and pemetrexed in the same populations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Highlands Oncology Group, Fayetteville, Arkansas +66 locations
Conditions: Metastatic NSCLC - Non-Small Cell Lung Cancer, Locally Advanced NSCLC - Non-Small Cell Lung Cancer
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Tau Networks in Psychotic Alzheimer's Disease
NCT05847192
Recruiting
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social cognition, working memory and executive function deficits). The investigator's previous work suggests a role of tau pathology (one of the hallmarks of AD neuropathology) in the manifestation of psychosi... Read More
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
09/04/2024
Locations: The Feinstein Institutes for Medical Research, Manhasset, New York
Conditions: Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
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Triheptanoin for Children with Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency
NCT06340685
Recruiting
This is a medical research study to test a medication in patients with a disease called Pyruvate Dehydrogenase Complex (PDC) Deficiency. The medication is triheptanoin, which is currently FDA approved for the treatment of Long-Chain Fatty Acid Oxidation Disorders. Previous research suggests that triheptanoin may also be effective in the treatment PDC Deficiency. This study will investigate the safety and efficacy (how well it works) of triheptanoin in patients with PDC Deficiency.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
09/04/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency
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Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
NCT02602769
Recruiting
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obe... Read More
Gender:
ALL
Ages:
Between 2 years and 20 years
Trial Updated:
09/04/2024
Locations: Boston Children's Hospital, Boston, New York +1 locations
Conditions: Childhood Obesity, Morbid Obesity
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Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI
NCT04251130
Recruiting
The investigators will conduct a tau PET scan in cognitively normal older adults and patients with Mild Cognitive Impairment (MCI), enrolled in the National Alzheimer's Coordinating Center (NACC) study at the University of Pennsylvania's Penn Memory Center/Alzheimer's Disease Core Center (PMC/ADC).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/04/2024
Locations: University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania
Conditions: Mild Cognitive Impairment
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Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)
NCT04938661
Recruiting
The purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/04/2024
Locations: University of Minnesota, Minneapolis, Minnesota +1 locations
Conditions: Acute Myocardial Infarction, Acute Coronary Syndrome, Stable Angina Pectoris, Percutaneous Coronary Intervention, Heart Failure
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Single and Combined Effects of Behavioral, Academic, and Medication Treatments for ADHD in the Classroom
NCT05469386
Recruiting
This study is the first to systematically evaluate the efficacy of single and combined academic accommodation, behavioral treatment, and medication treatment in a large sample of children with ADHD. Using a scientifically rigorous, cross-over design the impact of these approaches on ecologically valid measures of outcome (on-task behavior, quiz scores, academic productivity) will be assessed to inform effective school intervention.
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
09/04/2024
Locations: FIU Center for Childern and Families, Miami, Florida +1 locations
Conditions: ADHD
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Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)
NCT05852054
Recruiting
STEP-UP will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (GDM) and/or hypertensive disorders of pregnancy (HDP).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Cook County Health, Chicago, Illinois +1 locations
Conditions: Hypertension in Pregnancy, Gestational Diabetes Mellitus, Dysglycemia
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Strengthening the Connections to Opportunities for Prevention Engagement
NCT06442046
Recruiting
The Strengthening the Connections to Opportunities for Prevention Engagement (SCOPE) project will create a pathway for children and families from the City of Hartford to connect with a Connecticut Children's Care Coordinator (CC) in an effort to reduce levels of violence exposure.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
09/04/2024
Locations: Connecticut Children's, Hartford, Connecticut
Conditions: Interpersonal Violence, Structural Violence
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Dose Response of Epinephrine
NCT02692313
Recruiting
Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial function and atherothrombotic balance in humans. The specific aim of our study will be to determine the dose response effects of the key ANS counterregulatory hormone epinephrine on endothelial function, fibrinolytic balance and pro-atherogenic inflammatory mechanisms in healthy humans.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/04/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Diabetes Complications
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Treatment of Depression Post-SCI
NCT04263285
Recruiting
Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rTMS). rTMS is a type of non-invasive brain stimulation. Fourteen individuals with a cervical or thoracic level SCI and de... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/04/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Spinal Cord Injuries
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Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs
NCT04628039
Recruiting
This is study is comprised of three approaches. First, the investigators will conduct a retrospective cohort study to determine factors associated with COVID-19 severity and complications and understand COVID-19 outcomes, including all-cause mortality, post-discharge events, and impacts of rehabilitation services (third aim). The second aim is a mixed-method study and follows COVID-19 patients with repeated surveys to determine patient-reported functional outcomes, health recovery, and rehabilit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan +1 locations
Conditions: COVID-19, Chronic Lung Diseases
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