68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.
Recruiting
The study population consists of patients who undergo resection for somatostatin receptor-positive (SSTR-positive) CNS tumors, focusing on meningioma, and including esthesioneuroblastoma, hemangioblastoma, medulloblastoma, paraganglioma, pituitary adenoma, and SSTR-positive systemic cancers metastatic to the brain, such as small cell carcinoma of the lung. The study indication is to determine the diagnostic utility of 68Ga-DOTATATE PET/MRI in the diagnosis and management of patients with SSTR-po... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/18/2024
Locations: Weill Cornell Medicine, New York, New York
Conditions: CNS Tumors, Meningioma, Esthesioneuroblastoma, Hemangioblastoma, Medulloblastoma, Paraganglioma, Pituitary Adenoma
Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors
Recruiting
This is a single group study of participants with advanced solid tumors who have not been cured by other treatments. It is the first time the drug will be used in humans, and will be in two parts. The primary purpose of the parts are: * Dose Escalation Part: To evaluate the safety and tolerability and to determine the maximum tolerated dose and the recommended dose for expansion of ifinatamab deruxtecan (I-DXd). * Dose Expansion Part: To investigate the safety, tolerability and antitumor activ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: Cedars-Sinai Medical Center- Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California +24 locations
Conditions: Advanced Solid Tumor, Malignant Solid Tumor
Biomarkers of Increased Free Living Sleep Time
Recruiting
This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivit... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
12/18/2024
Locations: Sleep Wake Center--University of Utah, Salt Lake City, Utah
Conditions: Sleep Deprivation, Insufficient Sleep Syndrome, Sleep Wake Disorders
Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Recruiting
This phase II trial investigates the side effects of CD19 chimeric antigen receptor (CAR) T cells and acalabrutinib, and to see how well they work in treating patients with mantle cell lymphoma that has come back (relapsed) or does not respond to treatment (refractory). T cells are infection fighting blood cells that can kill cancer cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize CD19, a protein on the surfa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/18/2024
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Recurrent Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma
Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study
Recruiting
Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the inve... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
12/18/2024
Locations: Tulane University Medical Center, New Orleans, Louisiana
Conditions: Atrial Fibrillation, Stroke, Stroke, Cardiovascular, Vascular Cognitive Impairment, Strokes Thrombotic, Stroke, Ischemic
Manage Emotions to Reduce Aggression (MERA)
Recruiting
PTSD is one of the most prevalent mental health conditions affecting Veterans who have served since 9/11. Veterans with posttraumatic stress disorder (PTSD) report difficulty controlling impulsive aggression (IA). An inability to manage one's emotions (emotion dysregulation) is an underlying mechanism of IA. Reducing IA and increasing use of PTSD evidence-based psychotherapies are two critical missions for the Veterans Health Administration. The proposed research supports these missions by compa... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
12/18/2024
Locations: James A. Haley Veterans' Hospital, Tampa, FL, Tampa, Florida +1 locations
Conditions: Stress Disorders, Post-Traumatic, Aggression, Emotion Regulation
PPG to Predict Ejection Fraction and Other Echographic Data in the General Population
Recruiting
The investigators are aiming to investigate the association between ejection fraction (EF) determined by echocardiography and signals obtained from Photoplethysmography (PPG) in the general population. The investigators are also aiming to investigate the association between blood pressure and signals obtained from PPG in the general population. Finally, the investigators are also aiming to investigate the association between signals obtained from PPG in the general population to cardioechograph... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
12/18/2024
Locations: Tulane University Medical Center, New Orleans, Louisiana
Conditions: Valvular Heart Disease, Pericardial Disease, Cardiomyopathies
The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study
Recruiting
The aim of the Correlation Of CoAGulation-Atrial Fibrillation (COAG-AF) study is to prove that an increase in pro-thrombotic biomarkers in AF is associated with an increase in AF burden. Secondary objectives of the study are the following: * To investigate the impact of catheter ablation on serum pro-thrombotic biomarkers in patients with AF. * To correlate coagulation biomarkers with imaging features such as, the degree of fibrosis found on Late Gadolinium Enhancement Magnetic Resonance Imagi... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
12/18/2024
Locations: Tulane University Medical Center, New Orleans, Louisiana
Conditions: Atrial Fibrillation
Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Recruiting
The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize that patients with a higher baseline Utah fibrosis staging will experience a higher incidence of POAF. The study also aims to evaluate and compare the in-hospital mortality, length-of-stay (LOS), compl... Read More
Gender:
ALL
Ages:
Between 40 years and 120 years
Trial Updated:
12/18/2024
Locations: Tulane University Medical Center, New Orleans, Louisiana +2 locations
Conditions: Atrial Fibrillation, Atrial Arrhythmia, Atrial Flutter, Atrial Tachycardia
The Effect of Inelastic Compression System on Quality of Life in People with Chronic Venous Insufficiency
Recruiting
The purpose of this protocol is to measure the effect of the use of an inelastic compression system (ICS) on quality of life (QOL) in patients with chronic venous insufficiency (CVI) who have demonstrated limited or no compliance with prescribed compression stockings or bandage wraps.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: University of Miami, Miami, Florida
Conditions: Chronic Venous Insufficiency
A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery
Recruiting
The aim of this study is to find out the effects of TAK-330 compared with four-factor prothrombin complex concentrate (4F-PCC) as part of standard treatment other than Prothromplex Total for anticoagulation reversal in participants treated with Factor Xa inhibitors who require urgent surgery/invasive procedure. The participant will be assigned by chance to either TAK-330 or SOC 4F-PCC as part of standard treatment before surgery. Patients participating in this study will need to be hospitalize... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: University of California Davis Health System, Sacramento, California +48 locations
Conditions: Coagulation Disorder
A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE
Recruiting
This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE (Magnolia)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado +184 locations
Conditions: Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism