Circulating Biomarkers in the Development of Type 1 Diabetes
NCT05505669
Recruiting
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens. Insulin is a hormone that helps the body use sugar as a fuel and control blood-sugar levels. People with diabetes have problems making insulin. This is because their insulin-producing beta cells -in the pancreas-are damaged or destroyed. A biomarker is a biological molecule (such as DNA, RNA (the genetic material of cells) o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/26/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Diabetes
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Pulse Endovascular ReperFUSION for Acute Ischemic Stroke
NCT06052969
Recruiting
Prospective, multi-center, single-arm early feasibility study enrolling a minimum of 15 subjects at up to a minimum of 3 active investigational sites in the United States. The subjects must be diagnosed with acute ischemic stroke (AIS), must be post-mechanical thrombectomy, will have had intravenous thrombolytics, and have a visible MCA, ACA or PCA occlusive clot on initial angiographic imaging. Each subject will receive the Pulse NanoMED procedure after attempted neurovascular therapy to achi... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/26/2024
Locations: University of South Carolina - Prisma, Columbia, South Carolina
Conditions: Acute Ischemic Stroke AIS, Cerebral Arterial Disease
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Safe and Fast Radial Hemostasis Using Synergistic Strategies: SAFE & FAST Trial
NCT06549842
Recruiting
The Safe and Fast Radial Hemostasis using Synergistic Strategies (SAFE \& FAST) trial is an interventional study aimed at reducing the incidence of radial artery occlusion (RAO) rebound bleeding, and the required compression time after transradial approach (TRA) procedures, which have become the default access for coronary procedures globally. The hypothesis is that combining lower-dose heparin and radial hemostasis with simultaneous ipsilateral ulnar artery compression could achieve these i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Regional Hospital of Scranton, Scranton, Pennsylvania
Conditions: Cardiovascular Diseases, Bleeding, Arterial Puncture, Catheter Complications, Occlusion of Artery
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Serial MRI Scans During Radiation Therapy
NCT04188535
Recruiting
This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care cancer treatment) for participants with advanced esophageal cancer, glioblastoma, prostate cancer, vulvar cancer or pediatric glioma. The research study procedures include three MRI scans (one before, one during, and one after standard of care cancer radiation therapy) for participants with advanced es... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/25/2024
Locations: Brigham and Women Hospital, Boston, Massachusetts +1 locations
Conditions: Glioblastoma, Esophageal Cancer, Radiotherapy, Magnetic Resonance Imaging, MRI, Prostate Cancer, Vulvar Cancer, Pediatric Glioblastoma Multiforme
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Diaphragmatic Breathing Exercises in Total Knee Arthroplasty Patients
NCT04336579
Recruiting
Rationale: While total knee replacements (TKA) are one of the most commonly performed surgical procedures in the United States, this procedure can also be very painful. Postoperative mobilization and rehabilitation is vital to a patient's recovery, but inadequate pain control can impede patients' progress. Diaphragmatic breathing is an additional non-pharmacological and non-invasive tool with no adverse effects that could aid in recovery. This will serve as a pilot study for a possible larger co... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
08/25/2024
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Anesthesia and Analgesia
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Human Amnion Membrane Allograft and Early Return of Erectile Function After Radical Prostatectomy
NCT05842057
Recruiting
The purpose of this research study is to evaluate if placing a dehydrated human amnion chorion membrane (dHACM) over the nerves after removal of the prostate during surgery (radical prostatectomy) will allow an earlier recovery of erectile function and urinary control after surgery.
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
08/25/2024
Locations: University of Miami, Miami, Florida
Conditions: Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy
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Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
NCT03065465
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's lesions who are randomized as initial treatment with the new large over-the-scope-clip device for endoscopic hemostasis versus standard endoscopic hemostasis.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/24/2024
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California +1 locations
Conditions: Upper Gastrointestinal Hemorrhage
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CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
NCT05456035
Recruiting
Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to eit... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
08/24/2024
Locations: Judy Garber, Nashville, Tennessee
Conditions: Depression
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Effects of Vestibular Training on Postural Control of Healthy Adults Using Virtual Reality
NCT05941039
Recruiting
Postural instability is a common symptom of vestibular dysfunction that impacts a person's day-to-day activities. Vestibular rehabilitation is effective in decreasing dizziness, visual symptoms and improving postural control through several mechanisms including sensory reweighting. As part of the sensory reweighting mechanisms, vestibular activation training with headshake activities influence vestibular reflexes. However, combining challenging vestibular and postural tasks to facilitate more ef... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
08/24/2024
Locations: Clarkson University, Potsdam, New York
Conditions: Virtual Reality, Vestibular Training, Balance Assessment
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Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
NCT04150497
Recruiting
This is a first-in-human, open-label, dose escalation and expansion study of UCART22 administered intravenously to patients with relapsed or refractory B-cell acute Lymphoblastic Leukemia (B-ALL). The purpose of this study is to evaluate the safety and clinical activity of UCART22 and determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D)
Gender:
ALL
Ages:
Between 15 years and 70 years
Trial Updated:
08/23/2024
Locations: University of California, Los Angeles (UCLA) - Medical Center, Los Angeles, California +17 locations
Conditions: B-cell Acute Lymphoblastic Leukemia
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Telehealth-Enabled Versus In-Person Parent-Mediated Behavioral Treatment for Challenging Behaviors in Children With ASD
NCT05268796
Recruiting
The purpose of the research is to determine whether parent-mediated behavior therapy for challenging behavior commonly displayed by children with autism spectrum disorder (ASD) can be as effective when delivered via telehealth as when delivered in-person.
Gender:
ALL
Ages:
Between 2 years and 7 years
Trial Updated:
08/23/2024
Locations: Stanford University, Stanford, California +1 locations
Conditions: Autism Spectrum Disorder
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama +59 locations
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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