Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?
Recruiting
Near infrared spectroscopy (NIRS), a technique that relies on differential absorption of infrared light to provide relative estimation of tissue oxygenation, has been successfully used to monitor perfusion of various tissues, including muscle tissue of the lower extremity, however available research reports mixed success and this technology is not currently a standard of care for patients with leg fractures. The investigators propose use of NIRS technology in patients with diagnosis of tibial f... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/06/2025
Locations: UF Health, Gainesville, Florida
Conditions: Compartment Syndromes
Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials
Recruiting
This trial will study different outreach methods to assess impact on enrollment of underrepresented minorities (specifically African Americans) to early phase cancer clinical treatment trials. Both patients and providers (those seeing enrolled patients) will be enrolled and receive the study interventions or no intervention (control arm).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/06/2025
Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois
Conditions: Cancer, Malignancy, Malignant Neoplasm
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
Recruiting
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine (NAC) will ameliorate glutamatergic dysregulation, and thus will reduce both opioid and cocaine demand. These hypotheses will be tested with two specific aims. Specific Aim 1. Determine the reinforcing effects of cocaine in individuals with comorbid opioid and cocaine use... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/05/2025
Locations: University of Kentucky Laboratory of Human Behavioral Pharmacology, Lexington, Kentucky +1 locations
Conditions: Cocaine Use Disorder, Opioid Use Disorder
A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
Recruiting
A phase IIb clinical study to evaluate the safety and efficacy of single or multiple doses of LT3001 drug product in subjects with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
06/04/2025
Locations: CHI Memorial Hospital, Chattanooga, Tennessee +1 locations
Conditions: Acute Ischemic Stroke
A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer
Recruiting
This study will establish the preferred dose of lisinopril in men with non-metastatic prostate cancer undergoing radiation treatment. This study will also evaluate the effect of lisinopril on urinary symptoms and the impact of lisinopril on biomarkers and their association with urinary symptoms.
Gender:
MALE
Ages:
Between 18 years and 70 years
Trial Updated:
06/02/2025
Locations: Wilmot Cancer Institute, Rochester, New York
Conditions: Prostate Cancer, Radiation Toxicity, Urinary Complication
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Recruiting
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/29/2025
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +396 locations
Conditions: Plasma Cell Myeloma
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adults With Hodgkin and Non-Hodgkin Lymphoma
Recruiting
The purpose of this study is to assess the safety, tolerability, drug levels, and preliminary efficacy of relatlimab plus nivolumab in pediatric and young adult participants with recurrent or refractory classical Hodgkin lymphoma and non-Hodgkin lymphoma.
Gender:
ALL
Ages:
30 years and below
Trial Updated:
05/28/2025
Locations: Local Institution - 0077, Birmingham, Alabama +75 locations
Conditions: Lymphoma, Non-Hodgkin, Hodgkin Disease
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Recruiting
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Rogers Behavioral Health, Oconomowoc, Wisconsin +1 locations
Conditions: Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1)
Recruiting
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP) Intake Groups. During the Intake, detailed consent and eligibility assessment will be completed. Participants who are eligible at the Intake will be randomized (within site and Intake Group) to R or IP Treatment and Assessment Groups. Participants will be followed for 3 mon... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/23/2025
Locations: University at Buffalo, Buffalo, New York +1 locations
Conditions: Remote Vs. In-Person, Remote Visits, In-person Visits
Communicating Uncertainties Associated With the Benefits and Risks of New Cancer Drugs
Recruiting
This nationally representative randomized survey of US adults will evaluate the effect of using brief statements to communicate different sources of uncertainty about the benefits and harms of new cancer drugs on participants' decisions and understanding.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts
Conditions: Cancer
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
Recruiting
This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient clinic (IC) compared to treatment as usual aimed at reducing infection related readmissions and improving health outcomes in people hospitalized with an infection related to injecting opioids or stimulants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2025
Locations: George Washington University, Washington, District of Columbia +3 locations
Conditions: Opioid Use Disorder, Injection Related Infections, Stimulant Use Disorder
PT150 Drug for Use in Alcohol Use Disorder
Recruiting
The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
05/16/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Alcohol Use Disorder