Motivation for Exercise: a Mood-Based Focus
NCT06706180
Recruiting
The goal of this study is to assess the effects of an exercise-related video on exercise motivation and adherence. Specifically, the researchers are studying whether an exercise-for-mood video increase levels of exercise motivation as compared to an exercise-for-fitness video.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Exercise Motivation
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Quantitative Ultrasound to Assess Steatotic Liver Disease in Children
NCT06706856
Recruiting
This research study is being conducted to find out more about advanced ultrasound techniques to non-invasively evaluate liver disease in children. The investigators are developing advanced techniques for analyzing ultrasound data and images of the liver, and they will compare it to other established methods used to evaluate the liver, including liver MRI. The investigators plan to develop and test the advanced analysis techniques using conventional full-size ultrasound machines and, if possible... Read More
Gender:
ALL
Ages:
Between 9 years and 18 years
Trial Updated:
11/22/2024
Locations: University of California San Diego, La Jolla, California
Conditions: MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
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Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
NCT01860339
Recruiting
Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain development may play an important role in the etiology of HD. Huntingtin (HTT)is expressed during development and through life. In animal studies, th... Read More
Gender:
ALL
Ages:
Between 6 years and 30 years
Trial Updated:
11/21/2024
Locations: University of California Davis, Sacramento, California +5 locations
Conditions: Huntington's Disease
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International Registry for Men With Advanced Prostate Cancer (IRONMAN)
NCT03151629
Recruiting
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingd... Read More
Gender:
MALE
Ages:
21 years and above
Trial Updated:
11/21/2024
Locations: University of Alabama-Birmingham, Birmingham, Alabama +120 locations
Conditions: Prostate Cancer
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Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke
NCT03401762
Recruiting
The purpose of the study is to explore the feasibility of using a wearable device, called a myoelectric-computer interface (MCI), to improve arm movement in people who have had a stroke. Impaired arm movement after stroke is caused not just by weakness, but also by impaired coordination between joints due to abnormal co-activation of muscles. These abnormal co-activation patterns are thought to be due to abnormal movement planning.The MCI aims to reduce abnormal co-activation by providing feedb... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/21/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Stroke, Stroke, Acute
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Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
NCT03548454
Recruiting
Over 100 million Americans suffer from chronic pain resulting in annual cost of roughly $635 billion. Limited treatments are available for this widespread disease. The data supporting these treatments lack generalizability to patients with more serious medical and psychological comorbidities who are often excluded from explanatory efficacy trials. Our work aims to integrate randomized comparative effectiveness research with patient care. The investigators will randomize the patients and collect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Stanford Pain Management Center, Redwood City, California
Conditions: Chronic Pain
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HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
NCT03596086
Recruiting
Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in recurrent glioblastoma multiforme.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Houston Methodist Neurological Institute, Houston, Texas
Conditions: Glioblastoma Multiforme, Astrocytoma, Grade III
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HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM
NCT03603405
Recruiting
Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in newly diagnosed glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Houston Methodist Neurological Institute, Houston, Texas
Conditions: Glioblastoma, Anaplastic Astrocytoma
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Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
NCT03681275
Recruiting
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: Diaphragm Injury
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VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems
NCT03953768
Recruiting
Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of action is not well understood; however it is increasingly recognized that electrical stimulation of the vagus nerve may impact other organ systems in the body including the immune and gastrointestinal systems.... Read More
Gender:
ALL
Ages:
Between 0 years and 60 years
Trial Updated:
11/21/2024
Locations: Norton Healthcare, Louisville, Kentucky +3 locations
Conditions: Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
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Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
NCT04166877
Recruiting
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and after surgery. However, this drug has primarily been used for pain control in patients undergoing surgery. Patients in the ICU with injuries also need good pain control. Using magnesium may assist in dec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: UC Davis Health, Sacramento, California
Conditions: Trauma, Acute Pain
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Study of SX-682 Alone and in Combination with Oral or Intravenous Decitabine in Subjects with Myelodysplastic Syndrome
NCT04245397
Recruiting
This study will determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and recommended Phase 2 dose (RP2D) of SX-682 in the treatment of patients with Myelodysplastic Syndromes (MDS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Mayo Clinic, Jacksonville, Florida +6 locations
Conditions: Myelodysplastic Syndromes
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