A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study of K-645 in the Treatment of Multiple Migraine Attacks
NCT07116499
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, 3-period crossover study to evaluate the safety, tolerability, and efficacy of two dose levels of K-645 in the treatment of patients with acute migraine.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/14/2025
Locations: Excell Research, Inc., Oceanside, California +16 locations
Conditions: Acute Migraine
Register for Updates
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
NCT07128602
Recruiting
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. We'll study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, we'll measure thigh mu... Read More
Gender:
FEMALE
Ages:
Between 18 years and 35 years
Trial Updated:
08/14/2025
Locations: Ryan Zarzycki, Glenside, Pennsylvania
Conditions: Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function
Register for Updates
TAP Block Timing Study
NCT07064200
Recruiting
This study investigates whether administering TAP blocks pre-incision provides superior postoperative pain control and reduces opioid use along with other medications compared to post-incision administration in patients undergoing elective abdominal surgeries.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/14/2025
Locations: Weill Cornell Medical College - NewYork-Presbyterian Hospital, NY, New York
Conditions: Bariatric or General Abdominal Surgeries, Bariatric Surgery Patients
Register for Updates
PRIMARY Ancillary Substudy
NCT07103733
Recruiting
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological processes by which mitral valve prolapse (MVP) can impact left ventricular (LV) myocardial structure and function, and, thereby, predispose to arrhythmias and sudden death. Such insights are key to identifying interventions to reduce the long-term sequelae of heart failure... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/14/2025
Locations: Keck Hospital of the University of Southern California, Los Angeles, California +24 locations
Conditions: Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
Register for Updates
Wearable Device and Behavioral Support for Enhancing Arm Use After Stroke
NCT07042152
Recruiting
The goal of this study is to determine the effectiveness of behavioral support and feedback from a wearable device that senses arm movement in improving upper extremity function in a pilot, randomized controlled trial with chronic stroke patients
Gender:
ALL
Ages:
Between 18 years and 84 years
Trial Updated:
08/14/2025
Locations: University of California Irvine, Irvine, California
Conditions: Chronic Stroke Patients
Register for Updates
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
NCT06422143
Recruiting
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: CARTI Cancer Center ( Site 0006), Little Rock, Arkansas +188 locations
Conditions: Non-small Cell Lung Cancer, NSCLC
Register for Updates
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
NCT07024823
Recruiting
This study will evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses (SAD) and multiple ascending doses (MAD) of AZD4248 administered as an oral solution and intravenous (IV) infusion. Additionally, the study investigates the non-interventional feasibility of home measurement of serum creatinine in participants with diabetic kidney disease (DKD).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/14/2025
Locations: Research Site, Glendale, California +4 locations
Conditions: Chronic Kidney Disease
Register for Updates
Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)
NCT07125833
Recruiting
The main purpose of this research is to find out if a treatment called cryoneurolysis can reduce pain after reverse total shoulder replacement surgery. This treatment uses cold to temporarily block a nerve in the shoulder. The study will compare people who receive the treatment to those who do not, to see if it helps lower pain and reduce the need for opioid pain medications after a reverse total shoulder surgery (RTSA).
Gender:
ALL
Ages:
Between 30 years and 85 years
Trial Updated:
08/14/2025
Locations: Orthopaedic Specialists of Dallas, Rockwall, Texas
Conditions: Degenerative Joint Disease of Shoulder
Register for Updates
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
NCT07054489
Recruiting
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
08/14/2025
Locations: Henry Ford Health, Detroit, Michigan
Conditions: Heart Failure, Polygenic Score
Register for Updates
Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)
NCT07115004
Recruiting
This is a phase 3 study that will evaluate subcutaneous (SC) VGA039 in patients with von Willebrand Disease (VWD)
Gender:
ALL
Ages:
Between 12 years and 75 years
Trial Updated:
08/14/2025
Locations: Science 37, Inc., Morrisville, North Carolina
Conditions: Von Willebrand Disease (VWD)
Register for Updates
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
NCT06413498
Recruiting
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug. The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +96 locations
Conditions: Multiple Myeloma
Register for Updates
A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis
NCT07037901
Recruiting
The purpose of this study is to evaluate the efficacy and safety of different dose regimens of IMG-007, compared to placebo.
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
08/14/2025
Locations: Antelope Valley Clinical Trials, Lancaster, California +8 locations
Conditions: Atopic Dermatitis, Atopic Dermatitis Eczema, Eczema
Register for Updates