Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator
NCT04292405
Recruiting
Evaluate data accuracy of cardiac acoustic biomarkers (CABs) recorded by the Wearable Cardioverter Defibrillator (WCD) as compared to the AUDICOR AM acoustic cardiography recorder.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: MAYO Clinic, Rochester, Minnesota
Conditions: Heart Failure
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Arrhythmia Detection After MI
NCT05073419
Recruiting
Patients post acute myocardial infarction (AMI) have a high risk of mortality but the use of an implantable defibrillator in the early aftermath of an AMI has not been shown to improve patients' survival. The VEST trial recently demonstrated an improved overall survival in post AMI patients with the use of a wearable defibrillator. The same improvement was not demonstrated for the risk of sudden cardiac death. Monitoring patients after AMI using an implantable cardiac monitor (ICM) may document... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania
Conditions: Acute Myocardial Infarction
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Gait Rehabilitation to Treat FastOA
NCT05848622
Recruiting
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
08/02/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee, Knee Injuries, Cartilage, Articular, Gait
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Maternal And Infant Antipsychotic Study
NCT06049953
Recruiting
The goal of this observational study is to learn about maternal psychiatric course and infant development in pregnant individuals with severe mental illness, comparing those treated with antipsychotics to those treated with other medications or without medication. The main questions it aims to answer are: 1. Is risk of psychiatric relapse different among individuals who take antipsychotic medication, other medication, or no medication? 2. Are pregnancy and neonatal health outcomes different amo... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Antipsychotics, Pregnancy
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An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study
NCT06534892
Recruiting
The purpose of this study is: * To investigate the optimal timing for revaccination after the initial RSVPreF3 OA vaccine dose, * To evaluate the long-term immune persistence and safety up to 5 consecutive RSV seasons (approximately 60 months) of a single dose of RSVPreF3 OA vaccine, * To give the opportunity to participants who received only placebo in the RSVOA=ADJ- 006 study, to receive a dose of the RSVPreF3 OA vaccine and collect additional safety information.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/02/2024
Locations: GSK Investigational Site, Birmingham, Alabama +253 locations
Conditions: Respiratory Syncytial Virus Infections
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Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
08/02/2024
Locations: University of Alabama, Children's Alabama, Birmingham, Alabama +27 locations
Conditions: Neuroblastoma
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Intermuscular Coherence as a Biomarker for ALS
NCT05104710
Recruiting
The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a measure of intermuscular coherence (IMC-βγ), when added to current diagnostic criteria (Awaji criteria), can differentiate ALS from mimic diseases more accurately and earlier than currently possible. 2. Characterize IMC-βγ in neurotypical subjects by age, sex, race, and ethnicity. 3. Follow a cohort of... Read More
Gender:
ALL
Ages:
Between 20 years and 90 years
Trial Updated:
08/02/2024
Locations: University of California Center for Clinical Research, Irvine, California +3 locations
Conditions: Amyotrophic Lateral Sclerosis
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Implementation of Collaborative Care for Depression in VA HIV Clinics
NCT05901272
Recruiting
HIV Translating Initiatives for Depression into Effective Solutions (HITIDES) is a team-based service to manage depression in Veterans Living with HIV (VLWH). This service is more effective for managing depression than the care VLWH usually receive and saves resources. HITIDES is also liked by HIV care providers and VLWH. Despite this, no VA clinics currently offer this service. This study examines two approaches to engage clinics with HITIDES, the resulting effects on VLWH, and the costs of the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/02/2024
Locations: Central Arkansas Veterans Healthcare System , Little Rock, AR, Little Rock, Arkansas
Conditions: HIV, Depression
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Drug Excretion in Breast Milk
NCT06056583
Recruiting
This is a prospective, non-randomized, phase I study design evaluating the in vivo activities and expression of OCT1 and BCRP in mammary gland of lactating women at three time points postpartum.
Gender:
ALL
Ages:
Between 14 days and 50 years
Trial Updated:
08/02/2024
Locations: University of Washington, Seattle, Washington
Conditions: Lactation, Postpartum, Drugs in Breast Milk, Mammary Drug Transporters, BCRP, OCT1
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A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
NCT04462770
Recruiting
The purpose of this study is to evaluate the safety and efficacy of EPX-100 as adjunctive therapy in participants with Dravet syndrome.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
08/02/2024
Locations: Children's Hospital of Los Angeles, Los Angeles, California +26 locations
Conditions: Dravet Syndrome
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Gut Kidney Axis in Enteric Hyperoxaluria
NCT05124886
Recruiting
40 subjects with a confirmed diagnosis of IBD or \>6 months post-RYGB with a diagnosed USD event or kidney stone on imaging within the past three years and 40 healthy controls will be administered a high oxalate diet on Days 0-3 and Days 21-24 with a washout period on Days 4-7 and will be administered 250mg sodium oxalate on Days 8-20, via prepared spinach, from Weil Cornell Medicine's Clinical and Translational Science Center. Subjects will partake in four stool collections, four 24-h urine col... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/02/2024
Locations: NYU Langone Health, New York, New York
Conditions: Enteric Hyperoxaluria
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The Brain Processes Underlying Speech Motor Learning and Speech Production
NCT05918679
Recruiting
The aim of this research is to develop protocols that selectively target and improve speech-motor learning processes. Participants will be asked to name pictures, read words/sentences, and listen to sounds while their speech signals will be collected during the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: Arizona State University, Tempe, Arizona
Conditions: Healthy Adults
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