Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
Recruiting
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training" (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, non-invasive technique that is designed to boost cognitive training by enhancing learning and the brain's ability to reorganize conne... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/14/2024
Locations: Naval Medical Center San Diego, San Diego, California +1 locations
Conditions: Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment, Post Concussive Symptoms
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
Recruiting
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Mercy Hospital Fort Smith, Fort Smith, Arkansas +111 locations
Conditions: Refractory Differentiated Thyroid Gland Carcinoma
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Recruiting
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
11/14/2024
Locations: Northwestern University, Chicago, Illinois +5 locations
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
Recruiting
The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematopoietic stem cell transplant (HSCT) requiring treatment of graft dysfunction or failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: NYU Langone Health, New York, New York
Conditions: Graft Failure, Poor Graft Function
Elranatamab in Patients with Relapsed or Refractory AL Amyloidosis
Recruiting
This study will evaluate the safety, tolerability and efficacy of elranatamab in patients with relapsed or refractory AL amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: AL Amyloidosis
A Multi-Country Observational Study of Safety and Effectiveness of Elfabrio® in Fabry Patients
Recruiting
A multi-centre, multi-country, observational, non-interventional, retrospective and prospective (hybrid) study among Fabry disease participants treated with pegunigalsidase alfa (Elfabrio®) in routine clinical care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Infusion Associates, Grand Rapids, Michigan
Conditions: Fabry Disease
Corticosteroids for Post-Extubation Dysphagia
Recruiting
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal edema. Study was leveraged using the existing R01 grant infrastructure COMIRB # 21-3873, study design, and research methods. Patients for the study proposed will have already been enrolled in the R01 longitudinal cohort study. The sites to perform this study include Colo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Dysphagia, Laryngeal Edema
Gonadal Tissue Cryopreservation for Fertility Preservation in Children with a Disorder of Sex Development
Recruiting
The purpose of this study is to offer gonadal tissue freezing and storage to children who are diagnosed with a disorder of sex development (DSD), who are at increased risk of infertility and certain malignancies (cancer). This study involves the storage of gonadal tissue that is being removed for medical reasons (e.g. prevention of cancer development). It includes the processing and freezing of this gonadal tissue, hopefully for potential future use. The tissue will then be stored long-term unti... Read More
Gender:
ALL
Ages:
30 years and below
Trial Updated:
11/14/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: DSD, 46,XY, DSD, Ovotesticular, DSD, Sex Chromosome, Disorders of Sex Development, Disorder of Sex Development, 46,XY, Disorder of Sex Development, 46,Xy, Cbx2-Related
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
Recruiting
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer. The plan is to use this information to modify screening practices in the United States with the goal to decrease the number of people who die from esophageal cancer.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
11/14/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Gastro Esophageal Reflux Disease, Barrett Esophagus
Endovascular Exclusion of Thoracoabdominal And/or Paravisceral Abdominal Aortic Aneurysm
Recruiting
This is a study to assess the safety and effectiveness of endovascular treatment of thoracoabdominal (TAAA) and paravisceral abdominal (PVAAA) aortic aneurysms. The investigational operation involves placing a stent-graft over the aortic aneurysm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Division of Vascular Surgery, SFVAMC, San Francisco, California +1 locations
Conditions: Thoracoabdominal Aortic Aneurysm, Paravisceral Abdominal Aortic Aneurysm
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
Recruiting
Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.
Gender:
ALL
Ages:
All
Trial Updated:
11/13/2024
Locations: Clinical Trial Site, Aurora, Colorado +137 locations
Conditions: Atypical Hemolytic-Uremic Syndrome
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
Recruiting
Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch aneurysms) in patients at high risk for open surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: New York Presbyterian Hospital, New York, New York +1 locations
Conditions: Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic, Aortic Dissection, Thoracoabdominal