Rapid Sequencing of Approved Therapies in Patients with Metastatic or Unresectable Clear Cell Renal Cell Carcinoma
NCT05188118
Recruiting
This is a pilot, single-center, single-arm study where 20 patients with metastatic or unresectable clear cell renal cell carcinoma will receive same sequential treatment strategy (Cabozantinib for 12 weeks, then proceed with Ipilimumab plus Nivolumab immunotherapy x4 over 12 weeks, then subsequent therapies depending on treatment response for another 12 weeks \[Nivolumab for CR/PR/SD, Cabozantinib or Lenvatinib/Everolimus for PROG\]).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/04/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Renal Cell Carcinoma
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Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
NCT05254171
Recruiting
The study is a randomized, double-blind, placebo-controlled, multicenter study of standard treatment with nab-paclitaxel and gemcitabine with or without SBP-101 in subjects previously untreated for metastatic pancreatic ductal adenocarcinoma (PDA), including subjects who have received prior neoadjuvant or adjuvant treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Genesis Cancer and Blood Institute (SCRI), Hot Springs, Arkansas +92 locations
Conditions: Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Stage IV
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Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation
NCT05335434
Recruiting
This is a single center pilot study evaluating intraoral photobiomodulation for the prevention of oral mucositis in patients undergoing myeloablative allogeneic hematopoietic cell transplantation (alloHCT). Patients who are planned for alloHCT will receive daily intraoral photobiomodulation therapy (PBMT) using a novel LED device. The name of the study device involved in this study is: - THOR LX2.3 with LED Lollipop
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Myeloablative Allogeneic Hematopoietic Cell Transplantation, Intraoral Photobiomodulation Therapy, Oral Mucositis, Mucosal Ulcer
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Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD
NCT05380050
Recruiting
Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage in productive personal and social activities. Of the limited interventions available to address cognition, none rigorously train attention beyond strategy management. This study will evaluate an innovatively combined strategy training known as Goal Management Training pl... Read More
Gender:
ALL
Ages:
Between 30 years and 55 years
Trial Updated:
11/04/2024
Locations: North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, Florida
Conditions: Brain Injury, Cognition, PTSD, Intervention
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Exploration of Central Venous Catheter Protective Devices in the Pediatric Population: A Mixed Methods Study
NCT05415449
Recruiting
1. to determine the feasibility of utilizing a wearable device 2. to prospectively measure and evaluate parent and nurse satisfaction with the protective wearable device. This is a sequential, convergent mixed methods study design in which qualitative interview data will be collected first followed by quantitative data. Scheme and Outcomes: Identify eligible patients--Informed Consent--Provide education and two protective wearable device--Demographic data (electronic health record)--Interview... Read More
Gender:
ALL
Ages:
Between 0 years and 12 years
Trial Updated:
11/04/2024
Locations: Children's Health, Dallas, Texas
Conditions: Central Line
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MASA Valve Early Feasibility Study
NCT05452720
Recruiting
The MASA Valve Early Feasibility Study (MVEFS) multi-site interventional clinical trial within the United States of America with each center following a common protocol.The objective of the trial is to evaluate the safety and probable benefit of MASA Valve in the indicated subset of patients requiring Right Ventricular Outflow Tract Reconstruction (RVOTR). As an early feasibility study, the purpose is determine the feasibility of success of the device in order to gather early data towards a futu... Read More
Gender:
ALL
Ages:
Between 0 years and 22 years
Trial Updated:
11/04/2024
Locations: OSF Childrens Hospital of Illinois, Peoria, Illinois +4 locations
Conditions: Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels, Pulmonary Atresia, Ross Procedure
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North American Prodromal Synucleinopathy Consortium Stage 2
NCT05826457
Recruiting
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: University of California Los Angeles, Los Angeles, California +8 locations
Conditions: REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies, Multiple System Atrophy, REM Sleep Parasomnias
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Personalized Tobacco Treatment in Primary Care (MOTIVATE)
NCT05846841
Recruiting
This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This approach may increase effectiveness and adherence for the patient, and increase the clinician's likel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Physician's Role, Smoking Cessation, Smoking
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Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM
NCT06023186
Recruiting
The goal of this observational study is to measure the effect of mavacamten treatment on blood flow in the heart muscle (myocardium) in patients with obstructive hypertrophic cardiomyopathy. The main question it aims to answer is: • Does mavacamten treatment improve blood flow in the heart muscle? Participants will take mavacamten at the direction of their treating physician. Participants will complete 2 myocardial Positron Emission Tomography and Computed Tomography (PET-CT) scans. The first... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Obstructive Hypertrophic Cardiomyopathy
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Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
NCT06052397
Recruiting
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circad... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
11/04/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Delirium, Postoperative, Cognitive Decline, Dementia
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A Study of DCR-STAT3 in Adults With Solid Tumors
NCT06098651
Recruiting
This is a sequential, ascending-dose, multicenter study conducted in patients with refractory solid tumors designed to evaluate the safety, tolerability, and pharmacokinetics of DCR-STAT3.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Next Oncology, Dallas, Texas +1 locations
Conditions: Solid Tumor, Adult, Refractory Tumor
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A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors
NCT06190886
Recruiting
The goal of this clinical trial is to evaluate the safety and tolerability of escalating doses of PTX-912 in patients with locally advanced or metastatic solid tumors. To evaluate the PK and immunogenicity profile of PTX-912. To evaluate the preliminary anti-tumor activity of PTX-912. Participants will be treated with PTX-912 via iv infusion, every 2 weeks until progression of disease, unacceptable toxicity, or 12 months of total study therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: City of Hope National Medical Center, Duarte, California +2 locations
Conditions: Advanced Cancer, Solid Tumor, Metastatic Cancer
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