Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)
NCT06095583
Recruiting
The Study is a Phase 3, randomized, three-arm, double-blind, placebo-controlled, multi-regional clinical research study to evaluate the safety and efficacy use of toripalimab alone or in combination with tifcemalimab as consolidation therapy in patients with limited-stage small cell lung cancer without disease progression following chemoradiotherapy. Tifcemalimab is a monoclonal antibody against B and T lymphocyte attenuator (BTLA). Toripalimab is a monoclonal antibody against programmed death... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: Banner MD Anderson Cancer Center, Goodyear, Arizona +155 locations
Conditions: Limited-stage Small Cell Lung Cancer (LS-SCLC)
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Retrieval-Based Word Learning in Autistic Children
NCT06466876
Recruiting
Children on the autism spectrum sometimes have difficulty learning new words and using the newly taught information in different situations. In this study, the investigators are testing whether strategies that have been found to improve word learning in non-autistic children will also help autistic children. Specifically, the investigators aim to test whether autistic children learn words more successfully if novel words are taught by repeating the words to the child (re-study) or if the novel w... Read More
Gender:
ALL
Ages:
Between 4 years and 8 years
Trial Updated:
06/19/2024
Locations: Louisiana State University, Baton Rouge, Louisiana
Conditions: Autism Spectrum Disorder
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Exercise Effects on Adipose Tissue Structure and Function
NCT04812314
Recruiting
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the wei... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/19/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain
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OUD Smartphone Services
NCT06134882
Recruiting
The purpose of the research is to check whether services and materials made available through a smartphone app are helpful to people who have been diagnosed with opioid use disorder (OUD). Participants are asked to use an app to submit videos of themselves taking salivary drug tests to a secure online system. The app includes reminders, rewards, and activities, as well as access to live support. Study participation lasts one year and includes about 30 minutes each week submitting videos, an hour... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: Western Michigan University, Kalamazoo, Michigan
Conditions: Opioid-Related Disorders, Drug Abuse
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Assessing the Functional Movement Screen as a Reliable Physical Therapy Discharge Criteria for Chronic Lower Back Pain Patients
NCT06474429
Recruiting
Overview of Research Design and Objectives This study is a prospective, concurrent cohort study aimed at evaluating the reliability of the Functional Movement Screen (FMS) as a discharge criterion for patients with chronic lower back pain (LBP) undergoing physical therapy. The primary objective is to identify a benchmark FMS score that correlates with a low risk of recurrence and high levels of functional performance post-discharge. Specific Aims and Hypotheses The study specifically aims to:... Read More
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
06/19/2024
Locations: Texas Back Institute, Plano, Texas
Conditions: Chronic Lower Back Pain
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Metformin and Nightly Fasting in Women With Early Breast Cancer
NCT05023967
Recruiting
This phase IIb trial studies the combined effect of prolonged nightly fasting and metformin hydrochloride extended release in decreasing breast tumor cell proliferation and other biomarkers of breast cancer. Preventing invasive breast cancer or DCIS. Metformin is widely used to treat type II diabetes and is associated with a decreased risk of cancer and death in diabetic individuals. Intermittent fasting may protect cancer patients from the toxic effects of chemotherapy agents without causing ch... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: M D Anderson Cancer Center, Houston, Texas +2 locations
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma
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Virtual Incentive Treatment for Alcohol
NCT06265506
Recruiting
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention. This study will test a telehealth PEth-based CM model in a sample of adults with AUD (n=200), recruited via online platforms by randomizing individuals to six months of 1) an online cognitive behavioral therapy for AUD (CBT4CBT) and telehealth PEth-based CM (CM condition) o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: Washington State University, Spokane, Washington
Conditions: Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
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Molecular Detection of Advanced Neoplasia in Pancreatic Cysts
NCT03855800
Recruiting
Researchers are trying to find out whether new tests ("biomarkers") of blood, stool, pancreas cyst fluid, or pancreas juice can be used to diagnose malignant or pre-malignant changes in pancreas cysts.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
06/18/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Pancreas Cyst
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Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain
NCT04546685
Recruiting
Empowered Relief (ER) is a 1-session pain relief skills intervention that is delivered in-person or online by certified clinicians to groups of patients with acute or chronic pain. Prior work in has shown ER efficacy for reducing chronic pain, pain-related distress, and other symptoms 6 months post-treatment. The purpose of this randomized trial is to conduct the first feasibility and early efficacy test of online Spanish ER delivered to Spanish-speaking adult patients with chronic pain. Partici... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: 1070 Arastradero Rd, Palo Alto, California
Conditions: Chronic Pain
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Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
NCT05382208
Recruiting
The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of ant... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
06/18/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +19 locations
Conditions: Emphysema, HIV
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Intervention to Collect and Utilize Sexual Orientation and Gender Identity (SOGI) Information in Hospice
NCT05877391
Recruiting
Older sexual and gender minority (SGM) patients are at risk for receiving inequitable end-of-life care; those with Alzheimer's disease and related dementias (ADRD) are at particularly high risk. Failure to collect and integrate sexual orientation and gender identity (SOGI) data to identify patients' informal support systems may have adverse health consequences for SGM older adults, particularly for those dependent on informal caregivers to provide in-home support and assist with activities of da... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Sexual and Gender Minorities, Hospice, Alzheimer's Disease and Related Dementias
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Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell AntibodY
NCT06358638
Recruiting
This multicenter prospective study seeks to determine if daratumumab given, prior to HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus, can prevent pure red blood cell aplasia with an acceptable safety profile in patients with anti-donor red blood cell antibodies, achieving an event-free survival similar to transplanted patients without such antibodies.
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
06/18/2024
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Sickle Cell Disease
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