Cholinergic Mechanisms of Attention in Aging
NCT04756232
Recruiting
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/23/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Subjective Cognitive Decline
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The GUARDIAN Trial
NCT04884802
Recruiting
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/23/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska +15 locations
Conditions: Blood Pressure
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HPV in Sinonasal Ca: Retrospective Analysis Association of Human Papilloma Virus (HPV) Serology and Behavioral Risk Factors
NCT04979000
Recruiting
This is a case-control study designed to evaluate the role of anatomic site, gender and race in human papillomavirus-associated head and neck squamous cell cancers (HNSCC). We will explore the role of HPV, tobacco, alcohol and drug use, in HNSCC by tumor site with particular emphasis on the sinonasal cavity as well as differences in risk factors for HPV-positive HNSCC by gender and race.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Sinonasal Carcinoma, HPV-Related Squamous Cell Carcinoma
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High-Risk Veteran Initiative
NCT05050643
Recruiting
Veterans at high-risk for hospitalization, including those with complex care needs, represent a large population of VHA patients who often do not receive evidence-based primary care practices that would help them avoid the hospital and improve their health. The high-RIsk VETerans (RIVET) Program will implement evidence-based practices that can support VHA Primary Care teams to deliver more comprehensive and patient-centered care, better strategies to manage medications, and avoid unnecessary hos... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California +2 locations
Conditions: Multimorbidity
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Telehealth-Enabled Versus In-Person Parent-Mediated Behavioral Treatment for Challenging Behaviors in Children With ASD
NCT05268796
Recruiting
The purpose of the research is to determine whether parent-mediated behavior therapy for challenging behavior commonly displayed by children with autism spectrum disorder (ASD) can be as effective when delivered via telehealth as when delivered in-person.
Gender:
ALL
Ages:
Between 2 years and 7 years
Trial Updated:
08/23/2024
Locations: Stanford University, Stanford, California +1 locations
Conditions: Autism Spectrum Disorder
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Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
NCT05298605
Recruiting
The purpose of this research is to develop a culturally adapted "Faith in Action!" curriculum to train lay health navigators to provide breast cancer screening navigation to Korean American women within faith-based settings and evaluate whether the culturally adapted "Faith in Action!" curriculum increases adherence to breast cancer screening guidelines among Korean American women within faith-based settings in Los Angeles, California. The primary research procedures include trainings and key in... Read More
Gender:
FEMALE
Ages:
Between 45 years and 80 years
Trial Updated:
08/23/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California +1 locations
Conditions: Breast Cancer Female, Health Knowledge, Attitudes, Practice, Cancer Screening, Health Disparities
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Feasibility of Remote Activity Assessment and PRO Collection Among Transgender Cancer Survivors
NCT05391217
Recruiting
Prospective observational feasibility study to evaluate the role of wearable activity monitors to determine the feasibility and acceptability of remote monitoring using wearable technology and PROs to monitor fatigue and physical function in transgender cancer patients and survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Neoplasms, Chronic Disease
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An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis
NCT05505981
Recruiting
Spondylolysis, a stress fracture in the pars interarticularis of a lumbar vertebra, is the most common identifiable cause of low back pain (LBP) in adolescent athletes, occurring in 14-30% of athletes who experience LBP. Spondylolysis can cause significant pain and disability and months of exclusion from sports or an active lifestyle. Standard care of spondylolysis in adolescent athletes is primarily based on expert opinion, with dramatic variations in clinical practice, including restrictive br... Read More
Gender:
ALL
Ages:
Between 10 years and 19 years
Trial Updated:
08/23/2024
Locations: Children's Hospital of Colorado, Denver, Colorado +1 locations
Conditions: Lumbar Spondylosis
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Benefits of Endoscopic Bariatric Procedures
NCT05514288
Recruiting
This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty \[ESG\] or transoral outlet reduction \[TORe\]) as clinically indicated, and subsequent follow up clinic visits for up to one year.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/23/2024
Locations: Liliana Bancila, Los Angeles, California
Conditions: Obesity
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, Alabama +59 locations
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC
NCT05645380
Recruiting
This study will assess if the presence of immune system cells in and around the tumor impacts tumor shrinkage in patients receiving neoadjuvant chemoimmunotherapy for triple-negative breast cancer.
Gender:
FEMALE
Ages:
Between 18 years and 120 years
Trial Updated:
08/23/2024
Locations: The University of Kansas Cancer Center - Clinical Research Center, Fairway, Kansas +6 locations
Conditions: Triple Negative Breast Cancer, Breast Cancer
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Identification of Treatment Concentrations of Defactinib or VS-6766 for the Treatment of Patients With Glioblastoma
NCT05798507
Recruiting
This early phase I trial tests brain concentration level and safety of defactinib or VS-6766 for the treatment of patients with glioblastoma. Recently, two new drugs that seem to work together have been shown to have promising treatment effects in tissue culture and animal models of glioblastoma. Each inhibits a different glioblastoma growth pathway and when used together may create a larger effect on tumor growth than either alone. Growth pathway describes a series of chemical reactions in whic... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/23/2024
Locations: Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Conditions: Glioblastoma, Recurrent Glioblastoma
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