Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma
NCT05864534
Recruiting
Brain tumor treatment is hampered by the blood-brain barrier (BBB). This barrier prevents drugs carried in the bloodstream from getting into the brain. If the BBB can be opened, making it temporarily more permeable, drugs may able to better reach the brain tumor. In this trial we will implant a novel device with 9 ultrasound emitters, allowing temporary and reversible opening of the BBB to maximize brain penetration of drugs that modulate the immune system. The device will be implanted after rad... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Newly Diagnosed Glioblastoma, Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype, Gliosarcoma, Glioblastoma Multiforme
Register for Updates
Remotely Delivered, Culturally Tailored Weight Loss Interventions Among Latina Breast Cancer Survivors
NCT05930483
Recruiting
This clinical trial evaluates a remotely delivered, culturally tailored weight loss interventions in Latina breast cancer (BC) survivors. Cancer is the leading cause of death among Latinos, and among Latinas, BC is the leading cause of cancer death. An estimated 80% of Latinas in the United States have overweight/obesity, which is associated with poorer BC outcomes. However, few, if any, effective interventions exist to promote and maintain weight loss in Latina BC survivors. The development of... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
Register for Updates
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1
NCT06004830
Recruiting
This study seeks to determine the feasibility, acceptability, and preliminary efficacy of an intervention consisting of off-label use of a medication with strong efficacy data for alcohol use disorder (AUD) with medical management and a clinical pharmacist-delivered behavioral intervention in reducing alcohol use among individuals with HIV and AUD.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/24/2025
Locations: Atlanta VA Medical Center, Decatur, Georgia
Conditions: Alcohol Use Disorder, Hiv
Register for Updates
Mother-Baby Study - Relative Reinforcing Value (RRV)
NCT06072651
Recruiting
The study will test a model of biobehavioral mechanisms involved in the development of a system of emotion, attachment, and nutritive intake in the mother-infant dyad and the association of this system with maternal feeding behavior, child eating behavior, dietary intake, and adiposity. To participate in this study the infant must also be enrolled in long-term observational study, NCT06039878.
Gender:
ALL
Ages:
0 days and above
Trial Updated:
04/24/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Eating Behavior
Register for Updates
The Sequestration of Holistic Stress Management Techniques for Adults
NCT06098755
Recruiting
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life. In awareness of a support system, Bachelor's age 30 and older requirements were waived to accept the Bachelor's age 21-29 for verified relatives of an individual Humanitarian Veterans Association member; however, without BLOOD-QUANTUM to an individual Humanitarian Veterans Association member, the preferred Bachelor age is 30 years old... Read More
Gender:
MALE
Ages:
21 years and above
Trial Updated:
04/24/2025
Locations: Virtual Tribunal Monastery, Anchorage, Alaska
Conditions: Stress, Job
Register for Updates
Study of RAS(ON) Inhibitor Combinations in Patients With Advanced RAS-mutated NSCLC
NCT06162221
Recruiting
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with each other. The first three subprotocols include the following: Subprotocol A: RMC-6291 +/- RMC-6236 + SOC Subprotocol B: RMC-6236 + SOC Subprotocol C: RMC-9805 +/- RMC-6236 + SOC
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: City of Hope - Duarte, Duarte, California +57 locations
Conditions: Non-Small Cell Lung Cancer, NSCLC, KRAS, NRAS, HRAS-mutated NSCLC, KRAS G12C-mutated Solid Tumors, Lung Cancer, Lung Cancer Stage IV, Advanced Solid Tumor, Cancer, RAS G12D-mutated NSCLC
Register for Updates
Molecular Profile-related Individualized Targeted Therapy in Resected Pancreatic Cancer With High-Risk of Cancer Recurrence
NCT06228599
Recruiting
This is a prospective, open-label therapeutic interventional investigation designed to interrogate the efficacy and safety of individualized matched therapies in patients with pancreatic cancer at high risk of disease recurrence post-surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Froedtert Hospital & the Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Pancreas Cancer
Register for Updates
Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
NCT06339177
Recruiting
Background: Hemophagocytic lymphohistiocytosis (HLH) is a disease caused by disrupted immune function. People with HLH are prone to fevers and illnesses, which can be fatal. Some people develop a genetic form of this disease (pHLH), but researchers do not understand why some other people develop a nongenetic form (sHLH). They also do not have good ways to diagnose and treat sHLH. Objective: To learn about sHLH and why some people get it and others do not. Eligibility: Adults aged 18 years a... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
04/24/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis, Macrophage Activation Syndrome, Hyperinflammatory Syndromes
Register for Updates
A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
NCT06403345
Recruiting
The purpose of this study is to test the Green Activity Program that was designed with people living with memory challenges and their study partners to see if it can be done and if they enjoy the program. "Green activities" are nature activities that the person enjoys and can be done with other people or pets. For example, dog walking, hiking, outdoor yoga, and gardening are all green activities. The purpose of the program is to help people living with memory challenges participate in nature act... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
04/24/2025
Locations: Indiana University Bloomington, Bloomington, Indiana
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Subjective Cognitive Decline (SCD)
Register for Updates
Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
NCT06469944
Recruiting
This is a phase 1/2, multicenter, open-label umbrella platform study that will evaluate the safety and tolerability of sacituzumab tirumotecan with pembrolizumab and fluoropyrimidine chemotherapy for the first-line (1L) treatment of participants with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric, gastroesophageal junction, or esophageal adenocarcinoma. This substudy will have two phases: a safety lead-in phase and an efficacy phase.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 6927), Tucson, Arizona +36 locations
Conditions: Gastroesophageal Junction, Gastroesophageal Adenocarcinoma, Esophageal Neoplasms, Esophageal Cancer
Register for Updates
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
NCT06548191
Recruiting
The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early to moderate Alzheimer's disease (AD). It will also learn about the feasibility of practicing 14 h of nightly fasting in this group of older adults. The main questions it aims to answer are: * Does prolonged nightly fasting of 14 h can reduce markers o... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/24/2025
Locations: Shiley Marcos Alzheimer's Disease Center, San Diego, California
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Alzheimer's Disease
Register for Updates
Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
NCT06609369
Recruiting
The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/24/2025
Locations: Connecticut Mental Health Center, New Haven, Connecticut +1 locations
Conditions: Tobacco Use, Tobacco Cessation, Insomnia
Register for Updates