Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
NCT06466941
Recruiting
The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery. The main questions are: 1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia? 2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Acute Pain, Chronic Post Operative Pain, Opioid Use
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CNKSR2 Natural History Study
NCT06500260
Recruiting
This prospective natural history study is being conducted to define the electroclinical, neurodevelopmental, and behavioral characteristics of CNKSR2 epilepsy aphasia syndrome (EAS) and intellectual disability (ID) in children aged 6 to 21 years old with CNKSR2 mutations. The data collected from this study will serve as an external control to eventual clinical trials examining precision medicine investigational therapeutics that aim to improve the seizure burden and neurodevelopmental outcomes... Read More
Gender:
ALL
Ages:
Between 6 years and 21 years
Trial Updated:
07/11/2024
Locations: University of California, San Francisco (UCSF), San Francisco, California
Conditions: Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset, X-Linked Intellectual Disability
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Effectiveness of Qualia NAD+ Supplementation on Intracellular NAD Levels
NCT06505967
Recruiting
The goal of this clinical trial is to determine if Qualia NAD+ effectively increases NAD+ levels in the blood and to evaluate its safety. Researchers will compare Qualia NAD+ to a placebo (a look-alike substance that contains no active drug) to assess its efficacy in increasing NAD+ levels in the blood. Participants will: Take Qualia NAD+ or a placebo every day for 4 weeks. Undergo blood tests before and after the trial.
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
07/11/2024
Locations: Qualia Life Sciences, Carlsbad, California
Conditions: NAD+ Levels in the Blood
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Point of Care Ultrasound for the Detection of Esophageal Food Bolus
NCT06507670
Recruiting
This will be a prospective, observational, case-control study of adult patients presenting to the WellSpan York Hospital Emergency Department (YHED) with signs and symptoms of esophageal food or foreign body impaction. Point of care ultrasound (POCUS) will then be performed by a trained emergency physician to collect ultrasound data, including the presence or absence of direct visualization food bolus/foreign body, as well as secondary markers of dilatation, such as maximal esophageal area. Inve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2024
Locations: WellSpan Health York Hospital, York, Pennsylvania
Conditions: Esophageal Foreign Body, Esophageal Obstruction
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Pharmacogenetic Determinants Of Treatment Response In Children
NCT00730678
Recruiting
To investigate whether genetic polymorphisms in genes encoding proteins involved in the metabolism or effects of drugs or environmental agents influence the disposition or effects of these xenobiotic substrates. To investigate the nature of heritability and the genetic basis of pharmacogenetic traits by studying family members of individuals with specific genotypes.
Gender:
ALL
Ages:
All
Trial Updated:
07/10/2024
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: All Malignancies, Children Being Treated for Catastrophic Illness
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A More Engaging Visual Field Test to Increase Use and Reliability in Pediatrics
NCT02157025
Recruiting
The majority of young children do not think that visual field (VF) testing of peripheral vision is similar to a game; therefore, it is not surprising that they have difficulty maintaining attention during VF testing and thus the test reliability suffers as a consequence. Poor VF reliability has been a longstanding, major issue since it leads to an increased number of tests and/or longer duration of time needed to determine when there are true vision losses. Providers are less likely to obtain VF... Read More
Gender:
ALL
Ages:
Between 5 years and 8 years
Trial Updated:
07/10/2024
Locations: The Eye Care Institute, Fort Lauderdale, Florida
Conditions: Glaucoma, Suspect, Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System, Congenital Coloboma of the Optic Nerve, Optic Nerve Head Pits, Bilateral Congenital
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Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
NCT02735707
Recruiting
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19. REMAP-COVID is a sub-platform of REMAP-CAP th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of Florida, Jacksonville, Florida +407 locations
Conditions: Community-acquired Pneumonia, Influenza, COVID-19
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Study of Pyridostigmine With Ondansetron in Subjects With Anti-AchR Positive Myasthenia Gravis
NCT04226170
Recruiting
This is a phase II, single center, randomized, double-blind, placebo-controlled, study in patients with a diagnosis of anti-AchR antibody positive myasthenia gravis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Myasthenia Gravis
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Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1
NCT04480554
Recruiting
HIV infection, as well as exposure to opioids (including heroin), are associated with systemic immune activation including increased microbial translocation from the gut. The overall objective of this study is to define the impact of long-term mu-opiate receptor stimulation or blockage with medication for opiate use disorder (i.e, methadone, buprenorphine/naloxone, or extended-release naltrexone) on the kinetics and extent of immune reconstitution on HIV-1 infected people who inject opiate and i... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/10/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Opioid-use Disorder, HIV-1-infection, Immune Activation, Inflammation, Methadone, Buprenorphine, Naltrexone, Antiretroviral Treatment
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Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
NCT04731844
Recruiting
To explore the use of curcumin and piperine supplementation at a dose of 4 gram/5mg twice a day in early stage prostate cancer patient undergoing active surveillance or patients on observation for MGUS/ low-risk smoldering myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of Rochester, Rochester, New York
Conditions: Prostate Cancer, Multiple Myeloma, Smoldering Multiple Myeloma (SMM), Monoclonal Gammopathy of Undetermined Significance
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Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
NCT05304286
Recruiting
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobio... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/10/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Post-surgical Pain
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Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
NCT05336084
Recruiting
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increase the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if... Read More
Gender:
ALL
Ages:
Between 13 years and 15 years
Trial Updated:
07/10/2024
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Sleep
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