FOLFIRINOX + 9-Ing-41 + Losartan In Pancreatic Cancer
NCT05077800
Recruiting
The purpose of this study is to find out if an experimental drug will prevent metastatic pancreatic adenocarcinoma from becoming resistant to standard treatment for the disease. The names of the study drugs involved in this study are: * 9-ING-41 * Losartan * Ferumoxytol * FOLFIRINOX (made up of 4 different drugs): * 5-Fluorouracil (5-FU) * Oxaliplatin * Irinotecan * Leucovorin
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: Univesity of Colorado, Aurora, Colorado +2 locations
Conditions: Pancreatic Adenocarcinoma, Pancreatic Adenocarcinoma Metastatic
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VIGOR: Virtual Genome Center for Infant Health
NCT05205356
Recruiting
This study will provide rigorous evaluation of implementing a virtual genome center into community clinical settings without highly specialized resources, thereby offering generalizable insights as to how best to implement genomic medicine at scale and for other age groups. This intervention has great potential to address disparities in genomic medicine among low-income and underrepresented minority (URM) populations and will enhance capacity for providers and health systems to utilize highly sp... Read More
Gender:
ALL
Ages:
Between 0 days and 99 years
Trial Updated:
06/21/2024
Locations: USA Children's and Women's Hospital, Mobile, Alabama +8 locations
Conditions: Genetics Disease, Genetics/Birth Defects, Genetic Predisposition to Disease
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Oxytocin for Hypermobile Ehlers-Danlos Syndrome
NCT05405257
Recruiting
The purpose of this pilot study is to evaluate effect of IV oxytocin on chronic pain in patients with Hypermobile Ehlers Danlos syndrome.
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
06/21/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Hypermobile Ehlers-Danlos Syndrome, Pain Assessment
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Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma
NCT05948475
Recruiting
This study is a Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib versus Physician's Choice in Subjects with Fibroblast Growth Factor Receptor (FGFR)-altered, Chemotherapy- and FGFR Inhibitor-Refractory/Relapsed Cholangiocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: UCLA Medical Center, Santa Monica, California +86 locations
Conditions: Cholangiocarcinoma
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AURORA Study-A Transformative Approach to Support PrEP Medication Persistence
NCT06072443
Recruiting
This study is designed to test the hypothesis that, compared to oral PrEP, use of CAB-LA in underserved populations in a real-world setting supported by a digital health companion program will be associated with greater medication adherence, persistence, retention-in-care, and improved PROs. Patients in the study will receive current standard care for HIV prevention and be offered enrollment in the digital health companion program. Goal of the study is to evaluate medication adherence and persi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: West Virginia Health Right, Charleston, West Virginia
Conditions: HIV Infections
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Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
NCT06441695
Recruiting
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive abilities following ingestion after a suboptimal night of sleep. This study will enroll 30 healthy men and women who will be recruited by word of mouth, email contact, and direct contact from the greater Tampa Bay Area. To account for potential dropouts, we aim to enroll... Read More
Gender:
ALL
Ages:
Between 35 years and 50 years
Trial Updated:
06/21/2024
Locations: Applied Science & Performance Institute, Tampa, Florida
Conditions: Caffeine, Cognitive Change, Mood, Mood Change
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Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications
NCT02663362
Recruiting
The purpose of this study is to develop and refine the techniques for using magnetic resonance imaging and magnetic resonance spectroscopy to understand the composition and function of the human body
Gender:
ALL
Ages:
Between 12 years and 89 years
Trial Updated:
06/20/2024
Locations: Translational Research Institute for Metabolism and Diabetes, Orlando, Florida
Conditions: Human Body Composition, Human Body Function
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Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia
NCT03592290
Recruiting
To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.
Gender:
ALL
Ages:
Between 20 years and 45 years
Trial Updated:
06/20/2024
Locations: John B. Pierce Laboratory, New Haven, Connecticut
Conditions: Hypovolemia, Hemodynamic Instability
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Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
NCT04032990
Recruiting
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles. The purpose of this project is to test the safety, comfort, and practicality of a new therapy that stimulates the spinal cord to facilitate activation of arm and hand muscles while practicing grasping, pinching, and reaching movements. The long-term goal is to provide better therapies that will improve the ability of children with SCI to m... Read More
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
06/20/2024
Locations: Department of Neurosurgery, Louisville, Kentucky
Conditions: Spinal Cord Injuries
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A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection
NCT04706923
Recruiting
The purpose of this study is to determine the safety and tolerability of intravenous (IV) brincidofovir (BCV; SyB V-1901) 0.2 mg/kg, 0.3 mg/kg or 0.4 mg/kg dosed twice weekly (BIW) or 0.4 mg/kg dosed once weekly (QW) for 4 weeks in subjects with AdV, and IV BCV in subjects with CMV
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/20/2024
Locations: Research Site, Los Angeles, California +10 locations
Conditions: Adenovirus Infections, Cytomegalovirus Infection
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Natural History Study and Establishment of a Biorepository-TANGO2-related Disorder
NCT05374616
Recruiting
The study aims to establish a biorepository of individuals with TANGO2 deficiency to support scientific research and establish a comprehensive clinical database of affected individuals to understand the disease course.
Gender:
ALL
Ages:
0 days and above
Trial Updated:
06/20/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: TANGO2-related Disorder
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The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
NCT05746143
Recruiting
The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/20/2024
Locations: Keck Medical Center of USC, Los Angeles, California
Conditions: Spine Fusion, Lumbar Spine Degeneration, Pain, Postoperative, Lumbar Spine Spondylosis
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