Study of Hepatitis Eradication Receiving Protease Inhibitor Administration
Recruiting
This is a prospective, non-blinded cohort study that will assess the safety, tolerability, and antiviral efficacy of glecaprevir/pibrentasivir therapy given post-discharge to HCV-negative recipients of HCV infected donors. Patients who meet entry criteria will be enrolled while on the transplant waitlist. At the time of transplant, some donors will be HCV positive / NAT positive and some will not be infected. Enrolled patients who receive an HCV negative donor will serve as contemporaneous contr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Coronary Artery Disease, Morality
Early Antenatal Support for Iron Deficiency Anemia
Recruiting
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose of this research is to see if second trimester initiation of intravenous (IV) iron therapy is better than oral iron therapy for treatment of anemia in pregnancy by improving blood count, quality of life and reducing side effects.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Pregnancy Related, Anemia, Iron Deficiency, Anemia of Pregnancy
Cone Beam Breast CT for Breast Cancer Screening
Recruiting
Up to one thousand and twenty-eight (1028) patients from screening and diagnostic population will be enrolled and consented to participate in the study to create an enriched data set. These women will be enrolled from annual screening population and diagnostic workup population. The enrolled patient will undergo KBCT scans within 4 weeks of her screening or diagnostic mammography exam and before breast biopsy occurs if biopsy is needed.
Gender:
FEMALE
Ages:
30 years and above
Trial Updated:
04/17/2024
Locations: Port Orange Imaging Center, Port Orange, Florida +3 locations
Conditions: Breast Cancer
Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
Recruiting
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-1)
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/17/2024
Locations: Xenoscience, Inc., 21st Century Neurology, Phoenix, Arizona +85 locations
Conditions: Multiple Sclerosis
Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis
Recruiting
Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-2)
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/17/2024
Locations: HonorHealth Research Institute - Bob Bove Neuroscience Institute, Scottsdale, Arizona +90 locations
Conditions: Multiple Sclerosis, Relapsing-Remitting
The Use of Butyrate Therapy in Pediatric Ulcerative Colitis
Recruiting
Butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis. This is a feasibility study to determine the efficacy of butryate enemas in pediatric ulcerative colitis.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
04/17/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Ulcerative Colitis
Diet in the Management of Acromegaly
Recruiting
Impact of low carbohydrate and low gluten diet on acromegaly progression, symptoms, complications, and treatment outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Acromegaly
PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.
Recruiting
In accordance with the European Medical Device Regulation MDR 2017/745/EU, the legal manufacturers of medical devices are obliged to evaluate medical devices with regard to their clinical performance and safety. The VERTICALE® Cervical System is intended for immobilization and stabilization of spinal segments of the craniocervical junction (occipital-C2), subaxial cervical spine (C3-C7) and upper thoracic spine (T1-T3). Primary Objective: To assess the functional outcome and clinical benefit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: University of Illinois Hospital and Health Sciences System - UI Health, Chicago, Illinois
Conditions: Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
Recruiting
The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Harvard Eye Associates, Laguna Hills, California +32 locations
Conditions: Neurotrophic Keratopathy
Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery
Recruiting
This is a prospective, single-blinded, multicenter study evaluating the benefit of sinonasal irrigations following endoscopic pituitary surgery. The goal of this study is to create practice changing guidelines with objective data highlighting the importance of irrigations on postoperative outcomes for pituitary surgery.
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
04/17/2024
Locations: Barrow Neurological Institute at St. Joseph's Hospital and Medical Center, Phoenix, Arizona +1 locations
Conditions: Pituitary Tumor
Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection
Recruiting
This study aims to assess the clinical significance of the intracytoplasmic sperm injection (ICSI) with zona-pellucida (ZP) bound sperm compared to ICSI with embryologist selected sperm for patients undergoing in vitro fertilization treatment of their infertility.
Gender:
ALL
Ages:
Between 18 years and 41 years
Trial Updated:
04/17/2024
Locations: Reproductive Medicine Associates of Northern California, San Francisco, California
Conditions: Infertility
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
Recruiting
This is a first-in-human, Phase 1/2 study to evaluate LCB84, a TROP2-directed antibody-drug conjugate, alone and in combination with an anti-PD-1 Ab, in dose escalation (Phase 1) followed by dose expansion (Phase 2). The study population in dose escalation (Phase 1) consists of patients with advanced solid tumors refractory to standard of care, or for whom no standard of care exists. After the MTD and/or RP2D for single agent LCB84 is determined, dose escalation cohorts with select tumor types... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California +5 locations
Conditions: Advanced Solid Tumors