Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue
Recruiting
The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question: Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement? Does red light therapy improve forearm muscle endurance compared to a sham light exposure? Does beet-root juice... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/19/2024
Locations: Wake Forest Univesity, Winston-Salem, North Carolina
Conditions: Health Care Utilization, Healthy Aging
e-HERO: Ending the HIV Epidemic in Rural Oklahoma
Recruiting
The goal of this study is to increase HIV and syphilis testing and linkage to care, increase condom use, and promote PrEP uptake among sexual minority men (SMM) and American Indian (AI) men in rural Oklahoma, a state that is an Ending the HIV Epidemic (EHE) priority state. The proposed supplement aims to: refine our preliminary intervention strategy in partnership with a Community Advisory Board (CAB) and rural peer mentors, and to assess feasibility, acceptability, and preliminary impact of the... Read More
Gender:
MALE
Ages:
Between 17 years and 29 years
Trial Updated:
03/19/2024
Locations: Northern Arizona University, Flagstaff, Arizona
Conditions: Human Immunodeficiency Virus (HIV)
Study of the Role of Genetic Modifiers in Hemoglobinopathies
Recruiting
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts +25 locations
Conditions: Sickle Cell Disease, Thalassemia, Beta, Thalassemia Alpha, Hemoglobinopathies
Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer
Recruiting
This study is to evaluate the disease control rate and time to progression of the sequential combination of oxaliplatin with an alternative anti-metabolite Trifluridine/tipiracil hydrochloride mixture, TAS-102,(TAS-OX) as well as irinotecan in combination with TAS-102 oxaliplatin(TAS-OX) + Bevacizumab in late-line metastatic colorectal cancer (mCRC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Trinitas Hospital and Comprehensive Cancer Center, Elizabeth, New Jersey +8 locations
Conditions: Colon Cancer, Rectal Cancer
Evaluation of the Jarvik 2000 Left Ventricular Assist System With Post-Auricular Connector--Destination Therapy Study
Recruiting
This investigation will be conducted as an interventional intention-to-treat clinical study in a population of end stage heart failure patients who meet specific inclusion and exclusion criteria. The multi-center study will be prospective, dual-armed, non-blinded (open-label) and randomized, comparing a treatment group receiving the Jarvik 2000 LVAS with Post-Auricular Connector to an active control group treated with the PMA approved Thoratec HeartMate® II LVAS for Destination Therapy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/18/2024
Locations: Columbia/NY Presbyterian, New York, New York
Conditions: Heart Failure
Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress
Recruiting
The purpose of this research study is to learn more about variants in the TP53 gene both associated with Li-Fraumeni Syndrome (LFS), a hereditary cancer risk condition, and TP53 variants found in the blood for other reasons (e.g. ACE/CHIP and mosaicism).
Gender:
ALL
Ages:
All
Trial Updated:
03/18/2024
Locations: Boston Children's Hospital, Boston, Massachusetts +2 locations
Conditions: Li-Fraumeni Syndrome, TP53 Gene Mutation, Hereditary Cancer Syndrome, Clonal Hematopoiesis, Mosaicism
Veteran Support for Smoking Cessation Pilot Project (VAntage Pilot)
Recruiting
This is a proposal to conduct a pilot study to assess the feasibility of recruitment of Veteran smoker and support person (SP) dyads and study procedures in preparation for a large randomized pragmatic trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Minneapolis Veterans Administration Health Care System, Minneapolis, Minnesota
Conditions: Smoking Cessation
Video Images About Decisions for Ethical Outcomes in the Emergency Department (VIDEO-ED)
Recruiting
A randomized controlled trial of a video decision aid in the Emergency Department Setting to improve advance care planning documentation.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/18/2024
Locations: UC Davis, Davis, California +3 locations
Conditions: Emergencies
NTS-WBRT in Brain Metastases
Recruiting
This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT). This research study involves: * NTS-WBRT (normal tissue sparing whole brain radiation therapy) * Memantine standard of care drug
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Brain Metastases
Clinical Trial of Alpelisb and Tucatinib in Patients With PIK3CA-Mutant HER2+ Metastatic Breast Cancer.
Recruiting
Phase IB/II clinical trial of Alpelisb and Tucatinib in patients with PIK3CA-Mutant HER2-positive metastatic breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: University of Colorado Cancer Center, Aurora, Colorado +3 locations
Conditions: HER2-positive Metastatic Breast Cancer
Outcomes of the Nanoscopic Partial Meniscectomy Versus Standard Arthroscopic Partial Meniscectomy
Recruiting
Standard arthroscopy has been the gold standard for treatment of meniscus tears since the 1980's. The purpose of this study is to analyze the clinical outcomes of using the smaller diameter Nanoscope for partial menisectomy. The authors hypothesize that the Nanoscopic partial menisectomy patients will have less pain and return function faster than standard arthroscopy.
Gender:
ALL
Ages:
65 years and below
Trial Updated:
03/18/2024
Locations: MedStar Washington Hospital Center, Washington, District of Columbia +1 locations
Conditions: Meniscus Tear
Post-Market Feasibility Study of the Tenon Medical CATAMARAN™ SI Joint Fusion System
Recruiting
The purpose of this study is to evaluate the outcomes of patients with sacroiliac joint pain treated with the CATAMARAN SI Joint Fusion System.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/18/2024
Locations: Northwest Specialty Hospital, Coeur d'Alene, Idaho +5 locations
Conditions: Sacroiliac Joint Disruption, Degenerative Sacroiliitis