Down Syndrome Obstructive Sleep Apnea
NCT06043440
Recruiting
The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
04/18/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California +6 locations
Conditions: Down Syndrome, Obstructive Sleep Apnea
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Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
NCT06253104
Recruiting
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist device (LVAD) implantation amongst patients with cardiogenic shock. Advanced therapies such as OHT and VADs in the heart failure (HF) population may promote skeletal muscle mass and subsequent quality of life, but there is a lack of literature assessing muscle mass changes in... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/18/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Heart Failure, Muscle Atrophy, Skeletal Muscle Atrophy, Cardiogenic Shock
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RE104 Safety and Efficacy Study in Postpartum Depression
NCT06342310
Recruiting
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms in participants with moderate-to-severe postpartum depression (PPD) as compared to active-placebo.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/18/2025
Locations: Reunion Investigational Site, Birmingham, Alabama +37 locations
Conditions: Postpartum Depression
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RECOVER-SLEEP: Platform Protocol
NCT06404086
Recruiting
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and allows comparative analysis across the interventions. For example, objectives, measures, and endpoints are generalized in the platform protocol, but intervention-specific features are detailed in separate appendices. This platform protocol is a prospect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Banner University Medical Center Phoenix, Phoenix, Arizona +44 locations
Conditions: Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
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Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
NCT06473779
Recruiting
The objective of this study is to assess the potential for tezepelumab-treated patients (subcutaneous administration) to reduce maintenance therapy without loss of asthma control in adolescent and adults with severe asthma.. Study details include: 1. The study duration will be up to 72 weeks. 2. The treatment duration will be up to 68 weeks. 3. The visit frequency will be once every 4 weeks (Q4W).
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
04/18/2025
Locations: Research Site, Palmdale, California +83 locations
Conditions: Severe Asthma
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Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy for Multiple Myeloma or CD19+ Lymphoproliferative Disorder (LPD)
NCT06630104
Recruiting
This clinical trial evaluates the impact of preexisting and therapy-emergent germline and somatic variants on cytopenia in patients with multiple myeloma or CD19 positive lymphoproliferative disorder (LPD) following chimeric antigen receptor T-cell (CAR-T) therapy. The most common adverse event after CAR-T therapy is lower than normal blood cells (cytopenia) and up to one third of patients experience cytopenia that last longer than 30 days post-infusion. Germline and somatic variants are changes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +6 locations
Conditions: Lymphoproliferative Disorder, Multiple Myeloma
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eDoula Feasibility and Acceptability
NCT06785467
Recruiting
eDoula is an app that will give patients reading material and videos to watch based on their due date. It also provides helpful postpartum guidance. First, patients without access to the app will be recruited and surveyed on their labor and satisfaction outcomes. Then, recruitment will begin for the intervention arm of the study. Participants will be recruited to use the app and complete a survey during the postpartum period.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/18/2025
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Pregnancy Related
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A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
NCT06887959
Recruiting
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: Scottsdale Clinical Trials, Scottsdale, Arizona +6 locations
Conditions: Acute Pain
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IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Pediatric High-grade Glioma (HGG)
NCT06946680
Recruiting
This is a phase I study to assess the safety and feasibility of IL-8 receptor modified patient-derived activated CD70 CAR T cell therapy in CD70+ pediatric high-grade glioma
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
04/18/2025
Locations: University of Florida Health Children's Hospital, Gainesville, Florida
Conditions: High-grade Glioma
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Characterization of Phenotypic and Genotypic Regressors for Imaging
NCT01148381
Recruiting
The influence of genes on addictive and neuropsychiatric disorders is complex, especially given that multiple genes likely influence certain behaviors that are correlated with addiction. Researchers are interested in looking at the genetic information of individuals who are enrolled on National Institute for Drug Abuse studies to investigate specific genetic variants that may be related to substance abuse. Researchers will study the effects of genes on several aspects of thinking such as attenti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2025
Locations: National Institute on Drug Abuse, Biomedical Research Center (BRC), Baltimore, Maryland
Conditions: Healthy Volunteers, Substance Use Disorders
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Intra- and Inter-fraction Changes in Radiation Therapy
NCT02344121
Recruiting
Analysis to quantify intra-fraction, inter-fraction and post-treatment changes in tumor target volumes and surrounding normal organs in radiation therapy.
Gender:
ALL
Ages:
All
Trial Updated:
04/18/2025
Locations: Froedtert Hospital, Milwaukee, Wisconsin
Conditions: Cancer
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Mechanism of Non-invasive Magnetic Stimulation
NCT03394066
Recruiting
Background: Transcranial magnetic stimulation (TMS) is form of non-invasive brain stimulation. It is approved to treat depression. TMS may help decrease drug craving. It is important to understand how TMS affects the brain. Such a better understanding would help to design ways to treat drug addiction. Objectives: To learn how TMS affects the brain when it stimulates an area in the front of the brain. Also, to see how the stimulation affects the area stimulated and other connected areas. Elig... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/18/2025
Locations: National Institute on Drug Abuse, Baltimore, Maryland
Conditions: Healthy Volunteers
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