Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ
NCT05218044
Recruiting
Cryoablation or tumor freezing is a percutaneous, office-based procedure that is emerging as a minimally invasive, cost-effective alternative to surgery that is currently being evaluated in clinical trials for the management of for early-stage invasive breast cancer. The investigator will also evaluate the potential of cryoablation as a minimally invasive alternative to surgery for small areas of DCIS by examining its ability to achieve complete ablation of DCIS within the targeted cryoablation... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/02/2023
Locations: Office of Dennis R. Holmes, M.D., F.A.C.S., Glendale, California
Conditions: Ductal Carcinoma in Situ
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Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA
NCT05334576
Recruiting
In this prospective, single-arm, open-label, imaging and treatment study, the investigator will test the hypothesis that crizanlizumab will prevent the progression of silent cerebral infarcts in patients with sickle cell disease. Study participants will undergo brain MRI before initiation of crizanlizumab and at 6 and 30 months after starting crizanlizumab infusions. The crizanlizumab cohort will be compared to a matched, observational cohort of patients not receiving crizanlizumab.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/02/2023
Locations: Barnes-Jewish Hospital, Saint Louis, Missouri
Conditions: Sickle Cell Disease
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Impact of AI on Trainee ADR
NCT05423964
Recruiting
Adenoma detection rate (ADR) is a validated quality metric for colonoscopy with higher ADR correlated with improved colorectal cancer outcomes. Artificial intelligence (AI) can automatically detect polyps on the video monitor which may allow endoscopists in training to improve their ADR. Objective and Purpose of the study: Measure the effect of AI in a prospective, randomized manner to determine its impact on ADR of Gastroenterology trainees.
Gender:
ALL
Ages:
All
Trial Updated:
03/02/2023
Locations: LAC+USC Medical Center, Los Angeles, California
Conditions: Adenoma, Adenoma Colon, Colorectal Cancer
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Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
NCT05373745
Recruiting
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing) and chronic pain, Active Brains 1 and Active Brains 2. The investigators will assess how each program may help in improving multimodal physical, cognitive and emotional function. The investigators will also assess whether improvements in outcomes from the two programs ar... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
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Discovering Novel Cancer Treatment Options Using a Comprehensive NGS-based Molecular Testing Panel in the Community Setting ("DINOSAur")
NCT05692466
Recruiting
To prospectively identify cancer patients whose tumors express specific molecular markers targeted by therapeutic agents from a comprehensive molecular test, for the purpose of selecting the most clinically appropriate treatment in a pragmatic two arm trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/01/2023
Locations: Adventist Health Glendale, Glendale, California
Conditions: Stage III Solid Tumors, Stage IV Solid Tumors
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Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma
NCT03787602
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Merkel Cell Carcinoma (MCC) who have failed treatment with at least one anti-PD-1 or anti-PD-L1 immunotherapy or in combination with avelumab in MCC patients who are anti-PD-1 or anti-PD-L1 treatment naïve. Inhibition of MDM2 is a novel mechanism of action in MCC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado +50 locations
Conditions: Merkel Cell Carcinoma
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Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser
NCT04364217
Recruiting
Hypertrophic Burn Scars (HTBS) are often treated with Fractional CO2 laser therapy to improve cosmetic appearance. It has been noted that this leads to a reduction in the pain and itch associated with this type of scars. While this phenomenon is commonly described in the literature, the mechanism of pain and itch reduction in unclear. The investigators aim to better understand this process by histological evaluation of HTBS at different stages of laser treatment.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypertrophic Scar, Burn Scar
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Intralesional HPV Vaccine for Condylomata
NCT05087849
Recruiting
This study will investigate whether injecting genital warts with small quantities of the Gardasil 9 vaccine has an effect on the warts.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Human Papilloma Virus, Warts, Warts, Genital, Condyloma, Condylomata Acuminata
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Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor
NCT05745337
Recruiting
The goal of this study is to test the feasibility of guiding as-needed pharmacological rate control of atrial fibrillation (AF) by implantable cardiac monitors and to assess the impact of continuous beta-blocker therapy versus as-needed rate control on the following outcomes: (1) exercise capacity, (2) AF burden, (3) symptomatic heart failure, (4) biomarker assessment of cardiac filling pressures and cardio-metabolic health, and (5) quality of life in patients with atrial fibrillation and stage... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: University of Vermont Medical Center, Burlington, Vermont
Conditions: Atrial Fibrillation, Diastolic Dysfunction, HFpEF - Heart Failure With Preserved Ejection Fraction
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Ultrasound Cavitation Therapy for CLI
NCT05749250
Recruiting
In this study, we will explore how ultrasound exposure of ultrasound contrast agents, which produces beneficial shear-mediated bioeffects, can be used to treat patients with severe non-healing ulcers secondary to peripheral arterial disease (PAD). The primary outcome measure is whether ultrasound exposure to microbubble contrast agents in the inflow artery and at the wound site can accelerate wound healing. A secondary outcome measure is whether cavitation-related changes occur in tissue perfusi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Arterial Disease
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A Retrospective Trial to Evaluate the Micra Pacemaker
NCT04051814
Recruiting
This is a retrospective study of our patient population implanted with the Medtronic's Leadless single-chamber ventricular pacemakers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2023
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Pacemaker
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Atrial Fibrillation Ablation Registry
NCT04055961
Recruiting
The Atrial Fibrillation Ablation Registry (AFib Ablation Registry™) is designed to assess the prevalence, demographics, management, and outcomes of patients undergoing percutaneous catheter ablation procedures to treat atrial fibrillation (AF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2023
Locations: Hoah Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Atrial Fibrillation
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