Non Exudative AMD Imaged With SS-OCT- Extension
NCT04469140
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
ALL
Ages:
All
Trial Updated:
03/08/2022
Locations: University of California Los Angeles Doheny Eye Institute, Los Angeles, California +4 locations
Conditions: Dry Macular Degeneration
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Feasibility of Endovascular Repair of Ascending Aortic Pathologies
NCT03322033
Recruiting
The purpose of this early feasibility study is to investigate the outcome of selected patients with ascending thoracic aortic pathologies including type A aortic dissection, who are suitable for endovascular repair with the Medtronic Valiant PS-IDE Stent Graft System with the Captivia Delivery System (or the Valiant PS-IDE Stent Graft).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/07/2022
Locations: Baylor Scott & White The Heart Hospital, Plano, Texas
Conditions: Dissection of Thoracic Aorta
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KRT-232 and TKI Study in Chronic Myeloid Leukemia
NCT04835584
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or intolerant to a Tyrosine Kinase Inhibitor (TKI). This study is a global, open label Phase 1b/2 to determine the efficacy and safety of KRT-232 in patients with chronic phase CML (CML-CP) and accelerated phase (CML-AP) who have failed TKI treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2022
Locations: University of Alabama Birmingham, Birmingham, Alabama +25 locations
Conditions: Chronic Myeloid Leukemia
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Use of Nanodropper vs. Standard Eyedropper in Patients With Glaucoma and Ocular Hypertension
NCT05277870
Recruiting
The purpose of this study is to evaluate the safety, efficacy, and usability of an eyedrop bottle adaptor that creates smaller eyedrops, Nanodropper, in an open-angle glaucoma/ocular hypertension patient population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2022
Locations: University of Washington, Seattle, Washington
Conditions: Glaucoma, Open-Angle, Ocular Hypertension
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Study of Pembrolizumab Treatment After CYAD-101 With FOLFOX Preconditioning in Metastatic Colorectal Cancer
NCT04991948
Recruiting
The purpose of the CYAD-101-002 study is to assess the safety and clinical activity of CYAD-101 in patients with unresectable metastatic colorectal cancer administered concurrently with FOLFOX chemotherapy, followed by pembrolizumab treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/22/2022
Locations: Mayo Clinic, Jacksonville, Florida +4 locations
Conditions: Unresectable Metastatic Colorectal Cancer
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Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
NCT05233111
Recruiting
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an inpatient setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2022
Locations: Baylor Institute for Rehabilitation, Dallas, Texas
Conditions: Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
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PPROM Registry (Preterm Premature Rupture of Membranes)
NCT02997345
Recruiting
Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy is responsible for 40% of preterm births in the United States. The PPROM Registry aims to identify possible causes of PPROM, evaluate trends in expectant management, measure maternal and fetal care, and to review short term and long term outcomes of affected pregnancies and births.
Gender:
FEMALE
Ages:
Between 14 years and 55 years
Trial Updated:
02/14/2022
Locations: Www.Aapprom.Org/the-Registry, Denver, Colorado
Conditions: Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
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Health and Resilience Projects: Foundations
NCT05253235
Recruiting
The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents. Youth age 10-13 and their primary caregivers are randomly assigned to receive SAAF or to a control group. Participants complete baseline and follow-up measures regarding vulnerability to substance use based on a neuroimmune model of stress coping.
Gender:
ALL
Ages:
Between 10 years and 13 years
Trial Updated:
02/14/2022
Locations: Center for Family Research, Athens, Georgia
Conditions: Substance Use
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SIESTA for Acute Stroke Rehabilitation
NCT04536623
Recruiting
The SIESTA-Rehabilitation protocol combines two sleep-promoting interventions, (1) empowering nurses to reduce unnecessary disruptions and (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing, to determine its impact on relevant sleep and rehabilitation outcomes in the acute inpatient stroke rehabilitation setting compared to the standard of care. Our primary outcome is change in Quality Indicator (QI) score, a measure that has replaced the Functional Independence... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Sleep-Disordered Breathing
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Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
NCT04716803
Recruiting
The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a stem cell-based therapy that has been reported to preserve or improve the structure of joints. The Angel System is the device used in this study to concentrate bone marrow from the patient and is intended to separate a mixture of blood and bone marro... Read More
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
01/24/2022
Locations: University of California San Diego Koman Outpatient Pavilion, La Jolla, California
Conditions: Osteo Arthritis Knee
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Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers
NCT05217160
Recruiting
This study is intended to provide information from subjects who currently have painful, chronically open wounds and assess the pain reduction capacity of KeraStat® Gel with Morphine. In gathering data from subjects who have baseline pain from their chronically open wounds, the investigators can then evaluate the capacity of KeraStat® Gel plus Morphine in reducing the subjects daily pain levels, pain associated with dressing changes, and pain medication consumption.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2022
Locations: South Texas Aesthetic and Reconstructive Surgery, San Antonio, Texas
Conditions: Wound of Skin, Burns
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Qualification for Cone-Optogenetics
NCT05218928
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
All
Ages:
All
Trial Updated:
01/19/2022
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California +8 locations
Conditions: Retinal Dystrophies
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