Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)
NCT01088217
Recruiting
The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/11/2020
Locations: University of Colorado Denver, Aurora, Colorado +3 locations
Conditions: Idiopathic Pulmonary Fibrosis, Familial Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, Familial Interstitial Pneumonia
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Proton or Photon RT for Retroperitoneal Sarcomas
NCT01659203
Recruiting
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for further studies. "Investigational" means that the intervention is still being studied and that research doctors are trying to find out more about it. Retroperitoneal sarcomas are soft tissue tumors located at the far back of the abdomen. Typically, patients with retroperitone... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/01/2020
Locations: Rush University Medical Center, Chicago, Illinois +9 locations
Conditions: Retroperitoneal Sarcoma
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MCJR Joint Replacement Clinical Outcomes Database
NCT03328611
Recruiting
The purpose of this research study is to develop a database of information regarding the diagnosis, treatment, and outcome of participants who have had a joint replacement. The more information gathered, the better the investigators will be able to treat future patients who need a joint replacement. For example the investigators learn what works well to help design implants and treatment protocols for the future. The investigators publish manuscripts and present research findings around the worl... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/31/2020
Locations: Midwest Center for Joint Replacement, Indianapolis, Indiana
Conditions: Joint Replacement
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Noninvasive Spinal Stimulation in Stroke
NCT03714282
Recruiting
This is a randomized control trial that will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2020
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke
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Methadone and Quality of Postoperative Recovery
NCT03168958
Recruiting
Patients undergoing cardiac surgery often experience moderate to severe pain in the early postoperative period. A number of methods have been used to help control pain after surgery; however, each of these techniques adds additional costs and risks. A simple and effective way to decrease this pain is to administer a long-acting opioid in the operating room. Methadone is a opioid that can produce analgesia (pain relief) that lasts up to 48 hours when given in large doses (0.3 to 0.4 mg/kg). Previ... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/21/2020
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Quality of Recovery Scores
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Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Patients With Schizophrenia
NCT04519099
Recruiting
To evaluate the efficacy and safety of cariprazine at a target dose of 4.5 mg/d compared with placebo in prevention of relapse in patients with schizophrenia To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/d compared with placebo in prevention of relapse in patients with schizophrenia who were initially stabilized on a target dose of 4.5 mg/d
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
08/17/2020
Locations: Pillar Clinical Research, Bentonville, Arkansas +120 locations
Conditions: Schizophrenia
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Prospective Randomized Controlled Trial Describing the Recurrence Rate of Adenomas in Sessile or Flat Colonic Lesions 15mm or Larger Receiving Post-resection Site Treatment With Snare Tip Soft Coagulation
NCT04063280
Recruiting
A multi-center randomized controlled trial in only 24 patients showed a significant reduction of the recurrence rate by treatment of the normal appearing perimeter of the EMR defect using the argon plasma coagulator (2). A recent non-randomized trial suggested a substantial reduction by treatment of the perimeter with the snare tip in the soft coagulation mode (3).
Gender:
All
Ages:
Between 25 years and 99 years
Trial Updated:
08/07/2020
Locations: NYU Langone Health, New York, New York
Conditions: Colon Polyp
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Development of Childhood Anti-influenza Immunity
NCT03778203
Recruiting
More information is needed on how children fight off influenza virus, as they are at greater risk for developing severe influenza infection and tend to have weaker responses to influenza vaccination. The purpose of this study is to understand how a child's early exposure to influenza vaccine or infection with influenza virus prepares him or her to combat future infections with this virus. Investigators will learn about how protection develops following an influenza infection or vaccination and t... Read More
Gender:
All
Ages:
Between 3 months and 15 years
Trial Updated:
07/15/2020
Locations: University of Rochester, Rochester, New York
Conditions: Influenza, Human
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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
NCT04275453
Recruiting
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation. Standard preparation for the scan includes a ketogenic (high fat and low carbohydrate) diet for 24 hours and overnight fasting to help suppress the amount of sugar taken up in the heart muscle. However, Investigator still do not know if this preparation is the most effective method. So the Inves... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2020
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Healthy
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Delirium Prevention Protocol in Elderly Patients
NCT03591120
Recruiting
The current study aims to elucidate the effectiveness of a preventative delirium protocol in patients older than 65 years of age undergoing elective surgery.
Gender:
All
Ages:
Between 65 years and 89 years
Trial Updated:
07/07/2020
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Delirium
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A Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness
NCT04418518
Recruiting
There is currently no treatment available for COVID-19, the acute respiratory illness caused by the novel SAR-CoV-2. Convalescent plasma from patients who have recovered from COVID-19 that contains antibodies to the virus is a potential therapy. On March 25th, 2020, the FDA approved the use of convalescent plasma under the emergency investigational new drug (eIND) category. Randomized trials are needed to determine the efficacy and safety of COVID-19 convalescent plasma for acute COVID-19 infect... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
07/06/2020
Locations: Brooklyn Methodist Hospital, Brooklyn, New York +2 locations
Conditions: COVID-19
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Patient Registry of Blind Subjects With Sleep-related Problems
NCT01195558
Recruiting
Non-24-hour sleep-wake disorder (Non-24) is a condition experienced primarily by totally blind individuals that results in abnormal night sleep patterns and chronic daytime sleepiness. This is a research protocol to develop a patient registry of subjects who may suffer from Non-24 and who are blind. Subjects participate in the study through a phone survey. This registry will be used to better understand, sleep related problems in blind individuals, including the investigation of a potential trea... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/22/2020
Locations: Vanda Pharmaceuticals, Washington, District of Columbia
Conditions: Sleep-wake Disorder in Blind Individuals
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