Prevention of Obesity in Infants of Overweight and Obese Women
Recruiting
Maternal and childhood obesity have dramatically increased and continue to present a significant health problem. Studies show that offspring of overweight (body mass index, BMI >25-29.9) and obese (BMI ≥30) women are at increased risk of newborn and age 1-year adiposity, and infant adiposity predicts childhood and adult obesity. The investigators hypothesize that infants of overweight/obese (OW/OB) mothers have both relative hyperphagia and are provided human milk with increased caloric composit... Read More
Gender:
Female
Ages:
Between 16 years and 50 years
Trial Updated:
02/04/2022
Locations: Penn State College of Medicine, Hershey, Pennsylvania
Conditions: Infant Obesity
Feasibility of Home-based Exercise Program for Adults With Cystic Fibrosis
Recruiting
The main objective of this clinical pilot study is to evaluate the feasibility and impact of a home-based exercise program on clinical and patient-centered outcomes in adult with cystic fibrosis (CF) and inform the design of a larger clinical trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Cystic Fibrosis
SIESTA for Acute Stroke Rehabilitation
Recruiting
The SIESTA-Rehabilitation protocol combines two sleep-promoting interventions, (1) empowering nurses to reduce unnecessary disruptions and (2) a systematic protocol to screen, diagnose, and treat sleep-disordered breathing, to determine its impact on relevant sleep and rehabilitation outcomes in the acute inpatient stroke rehabilitation setting compared to the standard of care. Our primary outcome is change in Quality Indicator (QI) score, a measure that has replaced the Functional Independence... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Sleep-Disordered Breathing
Evaluation of Outcomes From Treatment of Benign or Malignant Gastroesophageal Diseases
Recruiting
This study will be a retrospective chart review of patients who have been diagnosed with benign or malignant pancreatic disease under the practice of Dr. Rohan Jeyarajah, M.D., Dr. Houssam Osman M.D., and Dr. Edward Cho M.D., Sc.M. at Methodist Health System Hospital in Richardson, TX. The Investigators plan to conduct an analysis of patients meeting the inclusion criteria from 2005 to present. Study will also be conducted by the PI, Sub-Is, surgery fellows, office staff and clinical research co... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: Trinity Surgical Consultants, Methodist Richardson Medical Center, Richardson, Texas
Conditions: Pancreatic Malignant Neoplasm Primary
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
Recruiting
In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment with Ofatumumab (Kesimpta®) will be less toxic to mouse-derived oligodendrocyte lineage cells, grown in a dish, than solutes secreted by the same leukocyte populations prior to treatment with Ofatumumab.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/03/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Relapsing Remitting Multiple Sclerosis
NECROtizing Soft Tissue Infections and Their Scoring System
Recruiting
Primary Objective: The primary objective of this study is to develop and validate a clinical risk index score for identifying NSTIs in emergency general surgery patients being evaluated for a severe skin and soft tissue infection. Secondary Objectives: To describe the contemporary microbiology of NSTIs and explore the effects on outcomes and to identify predictors of amputation and mortality.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
02/03/2022
Locations: Methodist Dallas Medical Center, Dallas, Texas
Conditions: Necrosis
Utilization of the Viracor® Assay for Valganciclovir Prophylaxis in CMV High Risk Kidney Transplant Recipients
Recruiting
The purpose of this study is to evaluate whether the use of the Viracor® CMV immunity assay at 6 months post-transplant in CMV high risk kidney transplant recipients would help identify those patients at higher risk of post-prophylaxis CMV viremia or disease and thereby select those patients in which a longer duration of valganciclovir prophylaxis would be beneficial.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2022
Locations: Piedmont Atlanta Hospital, Atlanta, Georgia
Conditions: Kidney Transplant; Complications
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol
Recruiting
A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2022
Locations: UCSD, La Jolla, California +8 locations
Conditions: Mucositis, Nephrotoxicity, Ototoxicity
(VIII): The Eight Study and Immunologic Response Sub-study
Recruiting
The study's objective is to test the hypothesis that immune system activation and subsequent systemic inflammation can be detected through continuously tracking multiple bio signals including physiologic variables (ECG, skin temperature and their derivatives) and behavioral variables (activity and sleep from accelerometers) collected during routine activities of daily living using wearable biosensors. In the sub-study, the objective is to explore the association between these objectively measure... Read More
Gender:
All
Ages:
All
Trial Updated:
02/02/2022
Locations: physIQ, Chicago, Illinois +1 locations
Conditions: Vaccine Reaction
HIV Prevention Peer Navigation for Justice Involved Women
Recruiting
Women involved in the criminal justice system have complex and highly stigmatized sexual and substance use risk profiles and are particularly vulnerable to, and experience, high rates of HIV. Criminal justice settings represent an important opportunity to address health disparities in HIV by linking women, who experience multiple, intersecting stigmas with innovative biomedical HIV prevention strategies, like pre-exposure prophylaxis (PrEP). The investigators propose to develop and test a peer-l... Read More
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
02/01/2022
Locations: University of California San Francisco, San Francisco, California
Conditions: HIV Infections, Stigma, Social
Association Between a Multi-Gene Panel and Renal Denervation Effectiveness in Patients With Hypertension
Recruiting
The purpose of this study is to assess the effectiveness of a multi-gene panel to determine which subjects are likely to respond to renal denervation therapy with Medtronic's Symplicity Spyral™ multi-electrode renal denervation system.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/01/2022
Locations: Baylor Scott and White Health, Dallas, Texas
Conditions: Hypertension
Study of TBX-3400 in Subjects With Solid Malignant Tumors Resistant or Refractory to Standard Therapies
Recruiting
This is a study of treatment with TBX-3400 in subjects with solid malignant tumors that are resistant or refractory to standard therapies. The subject's own blood cells are exposed to a protein that has been shown in the laboratory to result in anti-tumor activity. The study hypothesis is that TBX-3400 cells will enhance anti-tumor activity and improve the body's immune response to the tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2022
Locations: The Angeles Clinic and Research Institute, Los Angeles, California +1 locations
Conditions: Cancer, Tumor, Solid, Refractory Cancer