Vestibulopathy as a Cause of Imbalance in Parkinson
NCT04768647
Recruiting
Balance problems and falls are common in people with Parkinson's disease but respond poorly to dopamine stimulating medications suggesting other causes. The main goal of this study is to assess whether imbalance and gait problems in people with Parkinson's disease may be related to vestibular (inner ear balance center) changes not related to loss of dopamine in the brain.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
04/14/2025
Locations: VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan +1 locations
Conditions: Parkinson's Disease
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Cortical Excitability in Cyclic Vomiting Syndrome
NCT05256160
Recruiting
This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/14/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Cyclic Vomiting Syndrome
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Polypill in Acute Coronary Syndrome
NCT05514938
Recruiting
Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low. This contributes to worse patient outcomes and increased risk of morbidity and mortality. The once-daily polypill leverages a population-based strategy that has previously demonstrated efficacy in improving adherence and access to therapy in low-resource settings, making it an innovative approach for improving post-ACS ca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease
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Treatment of Parental Anxiety Virtual Reality (VR)
NCT05729347
Recruiting
The purpose of this study is to determine if non-invasive distracting devices (Virtual Reality headset) are more effective than the standard of care (i.e., no technology based distraction) for preventing anxiety in parental and pediatric populations
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/14/2025
Locations: Lucile Parkard Children's Hospital, Stanford, California
Conditions: Anxiety, Parents, Virtual Reality
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Transcranial Magnetic Stimulation for MCI
NCT05992831
Recruiting
The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients with comorbid depression. It is known that TMS can effectively treat depression. Identifying the right dose of accelerated TMS in MCI patients is necessary prior to designing subsequent trials to determin... Read More
Gender:
ALL
Ages:
Between 60 years and 85 years
Trial Updated:
04/14/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Mild Cognitive Impairment, Depression
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An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSD
NCT06215261
Recruiting
This study is evaluating the safety and efficacy of methylone in adults with PTSD. The study is conducted in two parts. * Part A is open-label and will enroll up to 15 participants with PTSD * Part B is randomized (1:1:1), single-blind and will enroll up to 45 participants with PTSD Eligible participants will enter a 3-week Treatment Period (Part A) or 4-week Treatment Period (Part B) where they will receive methylone once weekly. Following the Treatment Period, participants will enter a 6-wee... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/14/2025
Locations: Segal Trials, Lauderhill, Florida +11 locations
Conditions: Post Traumatic Stress Disorder
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The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)
NCT06321575
Recruiting
The objective of this study is to establish reasonable assurance of safety and effectiveness of the Golazo® Peripheral Atherectomy System when used as indicated in 159 subjects with symptomatic infrainguinal peripheral arterial disease (PAD) in up to 15 investigational sites in the U.S.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: HonorHealth Scottsdale Osborn Medical Center, Scottsdale, Arizona +11 locations
Conditions: Peripheral Arterial Disease
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Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer
NCT06495125
Recruiting
This phase II trial tests how well defactinib and avutometinib in combination with nivolumab works in treating patients with LKB1-mutant non-small cell lung cancer that has not responded (refractory) to an anti-PD1 treatment and may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Defactinib and avutometinib belong to a class of drugs called kinase inhibitors. These drugs target kinase proteins found in tumor cells. Tumor cells need... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Emory University Hospital Midtown, Atlanta, Georgia +2 locations
Conditions: Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
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A Study of CT-388 in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus
NCT06628362
Recruiting
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388 at low, middle, and high doses in participants who are overweight or obese with Type 2 diabetes mellitus (T2DM).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/14/2025
Locations: Pinnacle Research Group, Llc; Central, Anniston, Alabama +42 locations
Conditions: Overweight or Obese, Type 2 Diabetes Mellitus (T2DM)
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Opioid Drug Interaction Study
NCT06757140
Recruiting
This study will examine the effects of doses of opioid/placebo and doses of alprazolam/placebo, alone and in combination. The primary outcomes are pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) and pharmacokinetic outcomes (from blood samples) to determine the interaction effects of these compounds.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/14/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Drug Interactions, Drug Kinetics
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Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants
NCT06906809
Recruiting
The purpose of this study is to investigate the effect of coadministration of phenytoin or itraconazole on the pharmacokinetics of BGB-16673 in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/14/2025
Locations: Fortrea Clinical Research Unit Inc., Madison, Wisconsin
Conditions: Healthy Volunteers
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The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
NCT03845036
Recruiting
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the DASH dietary program combined with a home-based exercise program, quantified by a step activity monitor, to improve exercise and vascular outcome measures in patients with PAD.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
04/14/2025
Locations: O'Donoghue Research Building, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Claudication, Peripheral Artery Disease
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