Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
Recruiting
This Phase 2 Randomized Placebo Controlled Trial will determine if administering nebulized Dornase Alpha (rhDNase) to COVID-19 patients with respiratory failure is safe and will reduce 28-day mortality.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2021
Locations: University of South Alabama, Mobile, Alabama
Conditions: Covid19
Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment
Recruiting
This open-label study will evaluate EMB-001, comprised of metyrapone, a cortisol synthesis inhibitor marketed as a diagnostic drug for testing hypothalamic-pituitary-adrenal (HPA) axis function, combined with oxazepam, an anxiolytic and sedative/hypnotic benzodiazepine, to help smokers abstain from smoking during a 12-week trial period.
Gender:
All
Ages:
Between 21 years and 65 years
Trial Updated:
05/26/2021
Locations: Rose Research Center, Raleigh, North Carolina
Conditions: Smoking Cessation, Tobacco Use Disorder
Theta Burst Stimulation for Headaches After Traumatic Brain Injury
Recruiting
The purpose of this study is to evaluate if theta burst stimulation (TBS) can reduce chronic headaches caused by a traumatic brain injury (TBI). TBS is a safe, drug-free brain stimulation technique that uses magnets to create electricity and stimulate nerve cells in the brain. After repeated TBS sessions, the increased stimulation of nerve cells can alter the way the brain communicates with itself (by creating new neural pathways) which, in turn, can reduce pain symptoms. Participants in this st... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/26/2021
Locations: Minneapolis VA Health Care System, Minneapolis, Minnesota
Conditions: Post-Traumatic Headache, Transcranial Magnetic Stimulation, Brain Injuries, Traumatic, Quality of Life
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Recruiting
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period. The virus can cause this continued infection, or the virus causes immune system function disorder and post-infectious autoimmune disease. The clinical symptoms can be smell loss, taste loss to liver function disorder, kidney function failure, different. No matter how complicated the systems showed in the clinic, all of the symptoms are due to the specifi... Read More
Gender:
All
Ages:
All
Trial Updated:
05/23/2021
Locations: All Natural Medicine Clinic, LLC, Rockville, Maryland
Conditions: Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder), Post-Infectious Arthritis, Post-Infectious Polyneuritis, Post-Infectious Parkinsonism, Post-Infectious Hypothyroidism, Post Infectious Osteoarthritis, Anxiety Disorders, Depression, Depression, Anxiety, Depression, Bipolar, Insomnia, GERD, Gastro Esophageal Reflux, Hepatitis, Glomerulonephritis
Cardiopulmonary Rehabilitation in COVID-19 Longhaulers
Recruiting
This study will test the efficacy of treadmill exercise combined with supplemental oxygen during exercise and recovery for the treatment of persistent post-acute COVID-19 symptoms. Participants will be pseudo-randomized (stratified by age) to one of four conditions for 8 treatment sessions: 1) treadmill exercise plus supplemental oxygen, 2) treadmill exercise plus air, 3) supplemental oxygen only, 4) air only. All participants will then cross-over and receive 16 additional sessions of treadmill... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2021
Locations: Post-COVID Rehabilitation and Recovery Clinic at H&D Physical Therapy, New York, New York
Conditions: Covid19, Viral Syndrome
Drug-drug Interaction Study of CTP-543 and Rifampin in Healthy Adult Subjects
Recruiting
This is a Phase 1 open-label study of the effect of rifampin on the pharmacokinetics of CTP-543 in healthy subjects.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/20/2021
Locations: Clinical Pharmacology of Miami, Miami, Florida
Conditions: Healthy Volunteers
Hypertension Management in Family Practice
Recruiting
High blood pressure is the greatest threat to the global burden of disease, contributing to an estimated 9.4 million deaths a year. Cardiovascular disease morbidity and mortality are positively correlated with the degree of elevation of blood pressure, without any evidence of a threshold down to at least 115/75 mm Hg[2]. Hypertension is common, and nearly every clinician in every specialty deals either directly or indirectly with managing it or its consequences. The population age 65 years or o... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2021
Locations: LSU Health Sciences Center, New Orleans, Louisiana
Conditions: Hypertension
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Recruiting
To evaluate the Dayspring Active Wearable Compression Technology in enhancing lymph movement and its safety and effectiveness after lymphatic surgery
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2021
Locations: Dung Nguyen, MD, PharmD, Palo Alto, California
Conditions: Lymphedema, Lymphedema, Breast Cancer, Lymphedema Arm
NCI SBIR Contract for Patient Navigation Tool Prototype Development
Recruiting
GMG ArcData will create a mobile-based application to improve communications and data exchange among patients and navigators involved in new pancreas surgery oncology episodes of care. Functionality will align with care processes using smartphone and the EHR patient portal. GMG will apply user-centered design theory and behavioral psychology approaches to co-design, develop, and test usability of features that optimize patient navigators-patient encounters on scheduling issues, nutrition guidanc... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2021
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia
Conditions: Pancreas Cancer, Hepatobiliary Cancer, Patient Engagement
Pilot Study of a Multimodal Prehabilitation Pancreatic Cancer Program
Recruiting
The purpose of this research is to explore the benefits of an exercise and nutrition program during total neoadjuvant therapy (TNT) in preparation for surgery for participants that have pancreatic ductal adenocarcinoma (PDAC)
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pancreatic Ductal Adenocarcinoma
Registry and Biorepository for IBD in Central Texas
Recruiting
This is a prospective, non-interventional registry and biorepository for patients with IBD. Longitudinal follow-up data is collected from both patients and their treating gastroenterologist during routine clinical encounters. The biorepository will consist of prospective collection of blood samples, tissue samples, and fecal samples for research purposes, while the participants are undergoing a clinically-indicated procedure (i.e. venipuncture for routine tests, IV catheter placement, and/or end... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/13/2021
Locations: Dell Medical School, UT Austin, Austin, Texas
Conditions: Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
The Role of Naps and Overnight Sleep on Cognitive Learning in Preschoolers
Recruiting
The goal of this research is to understand the role of sleep on memory function in early childhood. Specifically, we seek to examine how promoted naps vs. promoted waking in habitual and non-habitual napping children may impact overnight sleep physiology and subsequent memory consolidation.
Gender:
All
Ages:
Between 33 months and 71 months
Trial Updated:
05/12/2021
Locations: University of Massachusetts, Amherst, Massachusetts
Conditions: Sleep