CHIP/CCUS Natural History Protocol
Recruiting
Background: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a change in a person s DNA that can increase a person s risk of developing blood cancers or cardiovascular disease. CHIP occurs mostly occurs in older people. Clonal cytopenia of undetermined significance (CCUS) occurs when one or more blood cell types is lower than it should be and is associated with a change in their DNA. Researchers want to learn more about how CHIP and CCUS progress. Objective: To examine the natural hi... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/10/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Clonal Hematopoiesis of Indeterminate Potential, Clonal Cytopenia of Undetermined Significance
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
Recruiting
The primary objective of the Outpatient Treatment with Anti-Coronavirus Immunoglobulin (OTAC) (INSIGHT 012) trial is to compare the safety and efficacy of a single infusion of anti-COVID-19 hyperimmune intravenous immunoglobulin (hIVIG) versus placebo among adults with recently diagnosed severe acute respiratory syndrome - coronavirus 2 (SARS-CoV2) infection who do not require hospitalization. The primary endpoint of this double-blind randomized trial is a five-category ordinal outcome that asse... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Southern Arizona VA Healthcare System (074-009), Tucson, Arizona +58 locations
Conditions: COVID, SARS-CoV2 Infection, Covid19
Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs
Recruiting
To assess the safety and tolerability of CK0804 as add-on therapy in participants with myelofibrosis, with suboptimal response to ruxolitinib
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: UC Davis Health, Sacramento, California +3 locations
Conditions: Myelofibrosis
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Recruiting
This is a Phase II, open-label, multi-drug, multi-centre study designed to assess the efficacy, safety, tolerability, pharmacokinetics, and immunogenicity of novel combination therapies in participants with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Research Site, Los Angeles, California +43 locations
Conditions: Gastric Cancer
A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors
Recruiting
This is an open-label, multicenter, and nonrandomized dose escalation and dose expansion study to evaluate BGB-26808 as monotherapy or in combination with tislelizumab in participants with advanced solid tumors. The main purpose of this study is to explore the recommended dosing for BGB-26808.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Yale University, Yale Cancer Center, New Haven, Connecticut +22 locations
Conditions: Advanced Solid Tumor, Solid Tumor
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The main aim of this study is to learn if TAK-279 reduces bowel inflammation and symptoms compared to placebo. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate any problems. The participants will take capsules of either TAK-279 or placebo for up to 3 months (12 weeks). Then all the participants will receive TAK-279 for the rest of the treatment part of the study (1 year or 52 weeks). During the study,... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/10/2025
Locations: GastroIntestinal BioSciences, Los Angeles, California +176 locations
Conditions: Ulcerative Colitis
Intervention Trial for Healthcare Workers With Anxiety
Recruiting
The purpose of the study is to conduct an initial test of the efficacy of Emotional Resolution (EmRes) therapy to reduce anxiety in healthcare workers. The investigators hypothesize EmRes will reduce levels of anxiety in participants compared to an active control group engaged in mindfulness-based gratitude.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Anxiety
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-Obstructive Disease
Recruiting
This study evaluates the safety, tolerability, and activity of inhaled GDC-6988 in patients with muco-obstructive disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Accel Research Site - Achieve - Birmingham - ERN - PPDS, Vestavia Hills, Alabama +1 locations
Conditions: Non Cystic Fibrosis Bronchiectasis, Chronic Obstructive Pulmonary Disease
Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)
Recruiting
Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/10/2025
Locations: AltaMed Health Services, Commerce, California +1 locations
Conditions: Adolescent Drinking, Cannabis Use
Tarlatamab in Advanced Delta-like 3 (DLL3)-Expressing Tumors Including Neuroendocrine Neoplasms
Recruiting
This study is being done to learn more about the drug tarlatamab in people with your condition. The purpose of this study is to see the efficacy (how well something works) of study treatment (tarlatamab) and whether it causes any side effects. Tarlatamab is being developed as an anti-cancer drug for tumors and is FDA-approved for extensive-stage small cell lung cancer. Tarlatamab is investigational for the purpose of this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: UC Davis Comprehensive Cancer Center, Davis, California +3 locations
Conditions: DLL3-expressing Tumors, Advanced Tumors
Enhancing Engagement by Integrating Goals and Concerns That Matter to Patients
Recruiting
The goal of this clinical trial is to learn if adding patients' goals and concerns to measurement-based collaborative care can tailor care and provide a more holistic view of treatment, thereby improving engagement in care among adult patients receiving collaborative care. The main questions it aims to answer are: * Does using a clinical decision support system (which includes an enhanced pre-visit questionnaire and patient-level dashboard) improve patient engagement in the collaborative care m... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/10/2025
Locations: Dartmouth Hitchcock Concord Family Medicine, Concord, New Hampshire +5 locations
Conditions: Anxiety Disorders, Depression Disorders
Early Adolescent Skills for Emotions
Recruiting
The EASE program is an existing, evidence-based program/intervention (originally developed by the WHO), and this study is limited to evaluating the local implementation of this program. The aims of this pilot study are to: * Assess the acceptability and feasibility of training and supervision of EASE Helpers (community staff members) through an adapted EASE training. * Evaluate possible problems of recruitment, intervention delivery, and participant retention. * Assess the feasibility of EASE... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
04/10/2025
Locations: The New School Center for Global Mental Health, New York, New York
Conditions: Community Mental Health Services