A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
NCT06586957
Recruiting
The goal of the Dose Escalation phase of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity to determine the preliminary recommended dose for expansion (RDE) of NKT3964 in adults with advanced or metastatic solid tumors. The goal of the Expansion phase of the study is to evaluate the preliminary anti-tumor activity of NKT3964 at the RDEs based on objective response rate (ORR) and determine the preliminary recommended Phase 2 dose (RP2D).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: University of Arkansas Medical School, Little Rock, Arkansas +7 locations
Conditions: Solid Tumor, Advanced Solid Tumor, Solid Tumor, Adult, Metastatic Tumor, Ovarian Cancer, Ovarian Neoplasms, Ovarian Carcinoma, Metastatic Ovarian Carcinoma, Endometrial Neoplasms, Endometrial Diseases, Metastatic Endometrial Cancer, Triple Negative Breast Cancer, Metastatic Endometrial Carcinoma, Advanced Endometrial Carcinoma, Advanced Ovarian Carcinoma, Gastric Cancer, Advanced Gastric Carcinoma, Metastatic Gastric Cancer, Metastatic Gastric Carcinoma, Small Cell Lung Cancer, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms, Platinum-resistant Ovarian Cancer, Platinum-refractory Ovarian Carcinoma, CCNE1 Amplification, Hormone Receptor Negative Breast Carcinoma, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Progesterone-receptor-positive Breast Cancer
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Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services
NCT06651086
Recruiting
This project aims to follow up on a prior project examining the impact of training therapists in an executive functioning intervention Unstuck and On Target (UOT) adapted for community mental health settings. Study aims are to test the clinical and implementation effectiveness of training mental health therapists in Unstuck and On Target, an executive functioning intervention, relative to Unified Protocol for Children, a transdiagnostic intervention for emotional disorders. This includes examini... Read More
Gender:
ALL
Ages:
Between 6 years and 99 years
Trial Updated:
04/14/2025
Locations: San Diego State University, San Diego, California +1 locations
Conditions: Autism Spectrum Disorder, Executive Functioning
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Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin
NCT06731933
Recruiting
The study objective is to see if BVEC induced C7 expression in Recessive Dystrophic Epidermolysis Bullosa (RDEB) skin following Squamous cell carcinoma (SCC) excision will normalize the invasive tumor microenvironment and reduce tumor recurrence. Prevention of SCC's in the RDEB subjects will increase their life span.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Stanford University, Redwood City, California +1 locations
Conditions: Squamous Cell Carcinoma
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Study of Obeldesivir to Treat Children With Respiratory Syncytial Virus (RSV) Infection
NCT06784973
Recruiting
The goal of this clinical study is to check if obeldesivir (ODV; GS-5245) is safe and well-tolerated by children with respiratory syncytial virus (RSV) infection. It will also look at how well ODV helps reduce the time it takes for children to feel better and for their RSV symptoms to improve. The primary objectives of this study are: a) to evaluate the safety and tolerability of ODV in pediatric participants with RSV infection; b) To evaluate the efficacy of ODV on time to alleviation of targe... Read More
Gender:
ALL
Ages:
5 years and below
Trial Updated:
04/14/2025
Locations: Midway Medical Clinic, Oneonta, Alabama +52 locations
Conditions: RSV Infection
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Long-term Safety of Nipple Sparing Mastectomy in Women With GPV in Breast Cancer
NCT06888388
Recruiting
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as to whether it is safe to do so. Relative to traditional or skin sparing mastectomy (SSM) techniques, nipple sparing mastectomy (NSM) is associated with improved psychosocial and sexual well-being and is significantly better for body image and reducing feelings of disfigur... Read More
Gender:
FEMALE
Ages:
Between 18 years and 90 years
Trial Updated:
04/14/2025
Locations: Yale University, New Haven, Connecticut +5 locations
Conditions: Breast Cancer Surgery
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Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines
NCT06929455
Recruiting
Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingr... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/14/2025
Locations: Monell Chemical Senses Center, Philadelphia, Pennsylvania
Conditions: Healthy Adults
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A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Lymphoma
NCT06939283
Recruiting
The goal of this clinical trial is to evaluate the safety and tolerability of the study drug WTX-330 when administered using a fixed dose regimen or a step-up dose regimen in adult patients with selected advanced or metastatic solid tumors or lymphoma. In addition to safety and tolerability, the study aims to: * determine the maximum initial dose of WTX-330 that may be used in the step-up dose regimen * determine whether the step-up dose regimen can increase WTX-330 exposure in patients due to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: HonorHealth Research Institute, Scottsdale, Arizona
Conditions: Advanced or Metastatic Solid Tumors, Non-Hodgkin Lymphoma
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Food and Microbiome Longitudinal Investigation (FAMiLI)
NCT03293758
Recruiting
The NYU Human Microbiome Study Cohort is designed to improve understanding of the role of human microbiome in health and disease. This study will serve as a critical NYU biorepository resource for research on human genetics and the microbiome in health and disease
Gender:
ALL
Ages:
40 years and above
Trial Updated:
04/14/2025
Locations: New York University School of Medicine, New York, New York
Conditions: Cancer, Cardiovascular Diseases
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Dual Mobility Acetabular Cups in Revision TJA
NCT04090359
Recruiting
The aim of this study is to the compare clinical outcomes of patients undergoing a revision total hip arthroplasty (THA) with the use of a dual mobility bearing versus a single bearing design with the use of a large femoral head (36mm or 40mm). We hypothesize the use of dual-mobility components in revision THA will be associated with a lower dislocation rate in the first year following surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: New York University Medical Center, New York, New York +1 locations
Conditions: Dislocation, Hip
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Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
NCT04623541
Recruiting
The study is a global, multi-center safety and efficacy trial of epcoritamab, an antibody also known as EPKINLY™ and GEN3013 (DuoBody®-CD3xCD20). Epcoritamab will be tested either in Relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) as: * Monotherapy, or * Combination therapy: * epcoritamab + venetoclax * epcoritamab + pirtobrutinib Treatment-naïve (TN) high risk (HR) (CLL): • epcoritamab + pirtobrutinib Combination therapy for Richter's Syndrome (RS): * epcoritamab + lenal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, Alabama +76 locations
Conditions: Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia
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The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
NCT04917796
Recruiting
This study is a randomized controlled trial of electroacupuncture (referred to as EA) versus sham acupuncture (referred to as EA) as effective treatments for Chemotherapy-Induced Peripheral Neuropathy/CIPN pain in cancer survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +5 locations
Conditions: Chemotherapy-induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful, Pain, CIPN - Chemotherapy-Induced Peripheral Neuropathy
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Novel Coding Strategies for Children With Cochlear Implants
NCT05203302
Recruiting
The purpose of this study is to understand performance with a cochlear implant. The long-term goals of this research are to improve sound perception with cochlear implants and to better understand the functioning of the auditory system. Information from individuals with and without cochlear implants will be compared.
Gender:
ALL
Ages:
Between 6 years and 80 years
Trial Updated:
04/14/2025
Locations: NYU Langone Health, New York, New York
Conditions: Deafness
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