Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy
NCT03716167
Recruiting
The laser emits an infrared light that heats the skin and underlying tissues with the purpose of temporary relief of minor muscle and joint pain, as well as stiffness associated with arthritis. The laser also causes a temporary increase in blood flow. The purpose of this study is to evaluate whether laser therapy can provide pain relief and speed the healing of venous leg ulcers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Venous Leg Ulcer
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Optimal Timing for Spontaneous Breathing Trials
NCT06561295
Recruiting
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU. SBTs are tests used to determine if a patient is ready to breathe on their own without the help of a ventilator. The study will compare two different timing strategies for these trials: one group of patients will have the test early in the morning, while the other group will have it later in the morning. By observing the outcomes, such... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
09/17/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Respiration, Artificial, Weaning
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MHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care
NCT04935606
Recruiting
The QUIT-Mobile study proposes to use mobile phone self-monitoring and feedback to enhance and sustain over 12-months the impacts of the Quit Using Drugs Intervention Trial (QUIT), an effective screening and brief intervention (SBI) previously successful in reducing risky drug use (i.e., moderate use) in low-income, diverse patients over a 3-month follow up. The investigators will conduct the QUIT-Mobile study for patients who receive care in clinics of federally qualified health centers (FQHC)... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: The Children's Clinic (TCC) Family Health, Long Beach, California +4 locations
Conditions: Drug Use
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A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
NCT05830097
Recruiting
The primary objective of this phase I study is to evaluate the safety and potential efficacy and to determine the recommended phase 2 dose (RP2D) of CBP-1019, a bi-specific ligand conjugated drugs in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: TOI Clinical Research LLC, Cerritos, California +4 locations
Conditions: Cancer, Breast, Cancer, Lung, Cancer of Pancreas, Cancer of Esophagus, Cancer Colorectal
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Brain Slice Explants to Predict Drug Response in Brain Tumors
NCT05978557
Recruiting
This biospecimen collection study will evaluate the feasibility of engrafting and testing resected Central nervous system (CNS) tumors tumor tissue ex vivo to estimate drug response, in pediatric and adult subjects. CNS tumors display remarkable heterogeneity and unfortunately there are no reliable precision oncology platforms that can identify the most effective therapy for each patient. Recent work has demonstrated the success of functional precision oncology platforms using patient-derived ex... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/19/2024
Locations: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Conditions: Central Nervous System Tumor
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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
NCT04510597
Recruiting
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, pembrolizumab, and avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +386 locations
Conditions: Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
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Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
NCT03781765
Recruiting
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
08/06/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: ADHD, Attention Deficit Hyperactivity Disorder
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Association of Near Infrared Spectroscopy With Interstage Outcomes
NCT06538571
Recruiting
The purpose of this study is to assess the utility of renal near infrared spectroscopy in the outpatient setting during the interstage period. The primary aim will be to determine the correlation between oxygen extraction ratio ((arterial pulse oximetry - renal near infrared spectroscopy value)/arterial pulse oximetry value) with need for inpatient admission or intervention. Secondary aims will be to determine the correlation of the oxygen extraction ratio with weight gain, neurodevelopment, une... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
08/05/2024
Locations: Advocate Childrens Hospital, Oak Lawn, Illinois
Conditions: Single-ventricle
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Drug Excretion in Breast Milk
NCT06056583
Recruiting
This is a prospective, non-randomized, phase I study design evaluating the in vivo activities and expression of OCT1 and BCRP in mammary gland of lactating women at three time points postpartum.
Gender:
ALL
Ages:
Between 14 days and 50 years
Trial Updated:
08/02/2024
Locations: University of Washington, Seattle, Washington
Conditions: Lactation, Postpartum, Drugs in Breast Milk, Mammary Drug Transporters, BCRP, OCT1
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Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues
NCT06171152
Recruiting
This study is for people who have multiple sclerosis, acute leukemia (in remission), or long-COVID and a Body Mass Index over 27 and may struggle with cognitive issues such as remembering information, concentrating, or making decisions that affect everyday life. By doing this study, researchers hope to learn how liraglutide (Saxenda®), a weight loss drug, affects levels of a certain disease marker in the body called Brain Derived Neurotrophic Factor (BDNF). Participation in this research will l... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2024
Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois
Conditions: Multiple Sclerosis, Long COVID, Long Covid19, Obese, Obesity, Obesity, Morbid, Acute Leukemia in Remission
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CorEvitas Rheumatoid Arthritis (RA) Drug Safety & Effectiveness Registry
NCT01402661
Recruiting
This prospective, non-interventional research registry is designed to study the comparative effectiveness and comparative safety of approved treatments for RA in a cohort of patients cared for by rheumatologists across North America. Secondary objectives include analyzing the epidemiology and natural history of the disease, its comorbidities, and current treatment practices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2024
Locations: CorEvitas, LLC, Waltham, Massachusetts
Conditions: Rheumatoid Arthritis
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Cultural Adaptation of Drug Treatment for DJJ Youth
NCT06003725
Recruiting
This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and focus groups with parents and guardians of Black JIY and community members who support change and reform in the justice community for Black JIY will be conducted.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
07/11/2024
Locations: University of California, San Francisco, San Francisco, California +1 locations
Conditions: Substance Use
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