A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP
NCT07119125
Recruiting
The principal aim of this study is to obtain safety and tolerability data when MRT-8102 is administered orally as single and multiple doses to healthy participants and participants at cardiovascular risk with elevated CRP. This information, together with the pharmacokinetic (PK) data, will help establish the dose and dosing regimen suitable for future studies. The study drug, MRT-8102, is experimental. This is the first study in which MRT-8102 will be given to humans. Part 1: Healthy participa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/05/2025
Locations: ICON Clinical Research, Lenexa, Kansas
Conditions: Healthy Volunteers, Elevated CRP
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Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
NCT07119398
Recruiting
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
08/05/2025
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Preterm PROM (Pregnancy)
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Changes in Hydration Status of PepsiCo Frontline Workers in a Manufacturing Facility Over the Course of Multiple Shifts
NCT07117773
Recruiting
Physically demanding occupations (PDO) require high levels of energy expenditure, mental acuity, and technical skills. Sometimes this work is performed in extreme environments during hot/humid summer months. Previous research shows that dehydration and heat stress can increase risk of heat-related illness, reduced cognitive function, and work capacity. While this impact of physically demanding work in extreme environmental conditions is often studied in firefighters, military personnel, and athl... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/05/2025
Locations: Gatorade Sports Science Institute, Bradenton, Florida
Conditions: Hydration Status
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A Study of BG-C477 in Participants With Advanced Solid Tumors
NCT06596473
Recruiting
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-C477 alone and in combination with anticancer agents in participants with selected advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: City of Hope National Medical Center, Duarte, California +12 locations
Conditions: Advanced Solid Tumors
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A Study of a Distress Screening and Referral Program in People With Recently Diagnosed Cancer
NCT07117461
Recruiting
It is recommended that cancer centers screen patients for distress and refer them to mental health services when their distress levels reach a certain level. However, many cancer centers don't have distress screening and referral programs. This study will provide valuable information about one distress screening and referral program and whether it can be helpful for a large and diverse group of cancer patients that includes both English- and Spanish-speaking patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York +1 locations
Conditions: Solid Tumor Cancer
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A Financial Intervention (Financial Compass) to Identify and Address Financial Hardship Among Head and Neck Cancer Patients, Financial Compass Trial
NCT06896695
Recruiting
This clinical trial compares the effect a financial intervention, called Financial Compass, to usual care in identifying and addressing financial hardship in patients with head and neck cancer. Previous research has shown that head and neck cancer patients experiencing financial hardship have decreased overall and cancer specific survival. Using a financial intervention, Financial Compass, may be more effective than usual care in identifying and addressing financial hardship in patients with hea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Head and Neck Carcinoma
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A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers
NCT06697600
Recruiting
This is a multicenter randomized controlled trial that assesses the efficacy of a decisional intervention \[University of Rochester-Geriatric Oncology assessment for Acute myeloid Leukemia (UR-GOAL)\] compared to an attention control.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/05/2025
Locations: University of Alabama at Birmingham, Division of Hematology and Oncology, Birmingham, Alabama +3 locations
Conditions: Oncology, Myeloid Leukemia, Acute, Cancer
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A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
NCT07086677
Recruiting
The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to t... Read More
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
08/05/2025
Locations: Orange County Research Center, Lake Forest, California +4 locations
Conditions: Streptococcus Pneumoniae
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Abbott Medical - VERITAS Study
NCT06707688
Recruiting
The primary objective of this study is to evaluate the safety and effectiveness of Abbott's Amulet™ 2 Left Atrial Appendage (LAA) occluder device (Amulet 2 device) in patients who have non-valvular atrial fibrillation and who are at increased risk for stroke and systemic embolism and have appropriate rationale to seek a non-pharmacologic alternative to oral anticoagulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Arizona Arrhythmia Research Group, Phoenix, Arizona +37 locations
Conditions: Atrial Fibrillation (AF), Stoke
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Telehealth to Improve Quality of Life in Persons Living in Rural Texas
NCT07119710
Recruiting
The overarching goal of this project is to evaluate a current evidence-based practice, Cognitive Behavioral Therapy, for mental health conditions against Cognitive Behavioral Therapy plus two check-in calls a week for adults living in rural Texas.
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
08/05/2025
Locations: Garrison Institute on Aging, Lubbock, Texas
Conditions: Mental Health Issue, Quality of Life
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A Study of mRNA-1345 Following a Primary Dose of a Licensed Protein Subunit Respiratory Syncytial Virus (RSV) Vaccine in Adult Participants ≥60 Years of Age
NCT07117487
Recruiting
The purpose of this study is to evaluate safety, tolerability and immunogenicity of mRNA-1345 in participants who have been previously vaccinated with either Arexvy or Abrysvo at least 12 months prior to enrollment, are medically stable and aged ≥60 years.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/05/2025
Locations: Velocity Clinical Research, Denver, Denver, Colorado +10 locations
Conditions: Respiratory Syncytial Virus
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A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors
NCT07107230
Recruiting
The purpose of this study is to determine recommended phase 2 doses (RP2Ds) of JNJ-95437446 in Part 1, and to further evaluate the safety of the RP2Ds in participants with advanced solid tumors in Part 2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Florida Cancer Specialists, Sarasota, Florida +1 locations
Conditions: Colorectal Neoplasms
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