Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)
Recruiting
The goal of this clinical study is to look at how lenacapavir (LEN) passes through the body and to assess the safety of LEN and emtricitabine/tenofovir disoproxil fumarate (F/TDF) for prevention of HIV in the cisgender women in the US. The primary objectives of this study are: 1) to characterize the pharmacokinetics (PK) of LEN in United States (US) cisgender women; 2) to evaluate the safety of LEN and F/TDF for pre-exposure prophylaxis (PrEP) in US cisgender women; and 3) to evaluate the gener... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: UAB, 1917 Research Clinic, Birmingham, Alabama +10 locations
Conditions: Pre-Exposure Prophylaxis of HIV Infection
Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition
Recruiting
To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of the nap, and brain structure and function (using Magnetic Resonance Imagining or MRI). Additionally... Read More
Gender:
ALL
Ages:
Between 36 months and 60 months
Trial Updated:
04/01/2025
Locations: University of Maryland, College Park, Maryland +1 locations
Conditions: Memory
PILI 'Āina Household
Recruiting
Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators will adapt and test an evidence-based multilevel intervention entitled PILI 'Āina to improve the self-management of prevalent cardiometabolic diseases and reduce risk factors for developing new diet-rela... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Kula no nā Po'e Hawai'i, Honolulu, Hawaii +1 locations
Conditions: Type 2 Diabetes, Hypertension, Dyslipidemias, Overweight and Obesity
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
Recruiting
The main purpose of this study is to evaluate the effect and safety of efgartigimod PH20 SC compared to placebo in adults with systemic sclerosis. The study consists of a screening period, a treatment period of up to 48 weeks and a safety follow-up period. After the screening period, eligible participants will be randomized in a 2:1 ratio to receive either efgartigimod PH20 SC or placebo. The total study duration can be up to approximately 15 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Arizona Arthritis and Rheumatology Associates, Phoenix, Arizona +2 locations
Conditions: Systemic Sclerosis (SSc)
Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors
Recruiting
The study regimen will be administered on an outpatient basis and all medications are administered intravenously (IV). Subjects will receive treatment on Day 1 and Day 15 of each 28-day cycle consisting of the following: nanoliposomal irinotecan at 50 mg/m2, followed by oxaliplatin 60 mg/m2, followed by leucovorin at 400 mg/m2 30 minutes after completion of oxaliplatin, followed by 5-FU 2400 mg/m2 60 minutes after leucovorin completion. Subjects will receive up to 6 cycles of NALIRIFOX then base... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Small Bowel Adenocarcinoma
Effect of Peanut Butter on Gut and Metabolic Health
Recruiting
The goal of this is parallel arm, randomized clinical trial is to learn and understand the effect of daily smooth peanut butter consumption on gut and metabolic health of children age 6-13. The main objectives are: Primary Objective: To determine the prebiotic effect of daily smooth peanut butter consumption for eight weeks on gut health, including microbiome-metabolome arrays, gut epithelial/barrier function, and gut transit time, in school-aged children. Secondary Objective(s) 1. To determi... Read More
Gender:
ALL
Ages:
Between 6 years and 13 years
Trial Updated:
04/01/2025
Locations: Florida State Univresity - The Gut Biome Lab, Tallahassee, Florida
Conditions: Dysbiosis
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
Recruiting
Management of leptomeningeal disease (LMD) in patients with metastatic breast cancer is an area of unmet clinical need. High-dose methotrexate (HD-MTX) is known to have activity against breast cancer and in contrast to other systemic chemotherapeutics, it penetrates the blood brain barrier, targets areas of poor cerebrospinal fluid flow, may penetrate bulky leptomeningeal disease, and provide treatment to systemic disease burden. While two retrospective studies have suggested activity of HD-MTX... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland +2 locations
Conditions: Metastatic Breast Cancer, Leptomeningeal Disease
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia
Recruiting
This is a Phase 2a study to evaluate the safety and pharmacokinetics (PK) of luspatercept in pediatric participants with β-thalassemia. The study will be conducted in 2 parts for both transfusion-dependent (TD) and non-transfusion-dependent (NTD) β-thalassemia participants: TD Part A will be in adolescent participants aged 12 to \<18 years with two dose escalation cohorts, followed by a dose expansion cohorts. NTD Part A will be conducted in the same age group participants as TD Part A with dos... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/01/2025
Locations: Local Institution - 601, Los Angeles, California +24 locations
Conditions: Beta-Thalassemia
Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma
Recruiting
This Phase II trial will evaluate progression-free survival after Stereotactic Body Radiation Therapy to oligoprogressive (1-5) lesions in metastatic renal cell carcinoma patients on any immune checkpoint inhibitor-containing regimen with last dose of systemic therapy within 3 months prior to trial enrollment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Oligoprogressive, Progression
MOTIV BTK Randomized Controlled Trial
Recruiting
Pre-market clinical evaluation of the MOTIV Sirolimus-Eluting Bioresorbable Scaffold for the planned treatment of infrapopliteal lesions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Adventist Health, Saint Helena, California +3 locations
Conditions: Critical Limb Ischemia
vGRID SBRT: A Phase I Clinical Trial in Unresectable or Metastatic HCC
Recruiting
This trial will provide the maximum tolerated dose for radiation therapy for liver tumors and describe the toxicity profile using the vGRID therapy technique. Based on trials using this type of radiation in other cancers demonstrating low toxicity rates even with very high radiation doses and high efficacy, it is likely that vGRID therapy in this trial will be well tolerated and allow dose escalation beyond currently common doses for liver tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Liver Cancer
A Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311/BNT324 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Research Site 111, Tucson, Arizona +94 locations
Conditions: Advanced Solid Tumors