Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
NCT06418204
Recruiting
This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed therapies with chemotherapy and/or (immune checkpoint inhibitors) ICIs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: Fairbanks Memorial Hospital, Fairbanks, Alaska +407 locations
Conditions: Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma, Non-Hodgkin Lymphoma
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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
NCT01042379
Recruiting
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +35 locations
Conditions: Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer
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Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
NCT04676802
Recruiting
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the ef... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/02/2025
Locations: Stanford Health Care, Redwood City, California +1 locations
Conditions: Pain, Postoperative, Osteoarthritis Thumb
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Improving Activity in Adults With Chronic Pain With Online Resources
NCT06804239
Recruiting
A randomized controlled study will test whether adults with chronic pain have improved outcomes when receiving a User Guide and weekly prompts for a newly designed Online Pain-Management Resource when compared to an active-control group that receives access to the Online Pain-Management Resource, but no User Guide or prompts. Outcomes of interest include measures of activity, sleep, pain and level of use of the online pain-management resource.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: Washington State University College of Nursing, Spokane, Washington +1 locations
Conditions: Chronic Pain
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Prospective Monitoring of Subjects With Biochemically Recurrent Prostate Cancer Using 18FDCFPyL
NCT05588128
Recruiting
Background: Prostate cancer is the second leading cause of cancer-related death in American men. The disease recurs in up to 50,000 men each year after their early-stage disease was treated; however, at this stage, imaging scans are often unable to find the disease in the body. In this natural history study, researchers want to find out if a new radiotracer (18F-DCFPyL) injected before positron emission tomography (PET) imaging can help identify sites in the body with cancer. Objective: To le... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Prostate Cancer, Biochemically Recurrent
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Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women With Hormone Receptor Positive Advanced Breast Cancer
NCT06123988
Recruiting
The purpose of this study is to test if four different programs (prolonged overnighting fasting alone, exercise alone, a combination of prolonged overnight fasting and exercise, or general health education sessions alone) can reduce fatigue in women with advanced or metastatic breast cancer who are receiving a medication called a cyclin-dependent kinases-4 and 6 (CDK4/6) inhibitor (e.g., palbociclib, ribociclib, or abemaciclib), with or without HER2-directed therapy (e.g., trastuzumab ± pertuzum... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: Arizona State University, Phoenix, Arizona +2 locations
Conditions: HER2-positive Breast Cancer, Advanced Breast Cancer
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Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/02/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +4 locations
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
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VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B
NCT06092333
Recruiting
Background: Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide; 887,000 die each year from cirrhosis, liver cancer, and related issues. Treatment options are limited. Objective: To test 2 drugs (VIR-2218 and peginterferon) in people with mild or inactive HBV infection. Eligibility: People aged 18 to 65 years with mild or inactive HBV infection. Design: Participants will be screened. They will have blood tests and an eye exam. They will have imaging scans of the... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Chronic Hepatitis B
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Transdermal Estrogen in Women With Anorexia Nervosa
NCT03875378
Recruiting
Randomized, placebo-controlled study investigating the use of physiologic, transdermal estrogen for low bone mass in adult women with anorexia nervosa.
Gender:
FEMALE
Ages:
Between 19 years and 45 years
Trial Updated:
08/02/2025
Locations: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Conditions: Anorexia Nervosa
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Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
NCT07103200
Recruiting
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
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A Study of LY4088044 in Healthy Participants
NCT07090785
Recruiting
The purpose of this study is to evaluate how well LY4088044 is tolerated and what side effects may occur in healthy participants. The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to check how much LY4088044 gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 92 weeks for Parts A, B, and C, excluding screening.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/01/2025
Locations: Collaborative Neuroscience Network - CNS, Los Alamitos, California +1 locations
Conditions: Healthy
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A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose
NCT07102095
Recruiting
This is a research study to understand how liver impairment affects the way the body processes a new cancer medicine called sevabertinib (BAY 2927088). Sevabertinib is an experimental drug being developed to treat certain types of cancers that have specific genetic changes called HER2 mutations. This includes lung cancer, tumors that have spread to other parts of the body (metastatic), and tumors that cannot be removed with surgery (unresectable). Before this medicine can be given to cancer pat... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/01/2025
Locations: Clinical Pharmacology of Miami, LLC - Oncology Department, Miami, Florida +1 locations
Conditions: Hepatic Insufficiency, Liver Diseases, Pharmacokinetics, Drug Metabolism
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