A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose
Recruiting
This is a research study to understand how liver impairment affects the way the body processes a new cancer medicine called sevabertinib (BAY 2927088). Sevabertinib is an experimental drug being developed to treat certain types of cancers that have specific genetic changes called HER2 mutations. This includes lung cancer, tumors that have spread to other parts of the body (metastatic), and tumors that cannot be removed with surgery (unresectable). Before this medicine can be given to cancer pat... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/01/2025
Locations: Clinical Pharmacology of Miami, LLC - Oncology Department, Miami, Florida +1 locations
Conditions: Hepatic Insufficiency, Liver Diseases, Pharmacokinetics, Drug Metabolism
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
Recruiting
This study will adapt and assess the preliminary effectiveness of a community health worker-delivered mental health counselling intervention delivered remotely to reduce anxiety and depression among people with HIV in Florida.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/01/2025
Locations: University of Florida, Gainesville, Florida
Conditions: HIV, Depression, Anxiety
Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib
Recruiting
The goal of this observational study is to better understand real-world use of vimseltinib, treatment patterns, and health-related quality of life in participants treated with vimseltinib for TGCT. This study will collect data in an observational disease registry involving no intervention to the participants and will not influence standard medical care or impact treatment decisions for participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: Synexus Clinical Research, US INC, Wilmington, North Carolina
Conditions: Tenosynovial Giant Cell Tumor
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
Recruiting
The purpose of this study is to evaluate the safety and feasibility of using seizure forecasts based on subscalp EEG.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/01/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Focal Epilepsy, Generalized Seizure, Drug Refractory Epilepsy
A Study of Tarlatamab for People With Prostate Cancer
Recruiting
The researchers are doing this study to find out whether tarlatamab is an effective treatment for DLL3-positive prostate cancer that has spread to other parts of your body (metastasized) and has either come back after treatment (relapsed) or not responded to treatment (refractory).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Metastatic Prostate Cancer
A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
Recruiting
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/01/2025
Locations: Associated Retina Consultans, Gilbert, Arizona +154 locations
Conditions: Wet Age Related Macular Degeneration, wAMD
Patient Empowerment and Agency Through Intrapartum Counseling and Education
Recruiting
A single-blind randomized controlled trial to study the effects of a labor guide on perceived control in labor. The experimental arm will receive an evidence-based labor guide at the time of admission for scheduled induction of labor. The control arm will receive the standard of care in-person counseling regarding options for labor interventions
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
08/01/2025
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Pregnancy Related
Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)
Recruiting
This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Kidney Stones, Nephrolithiasis
A Study to Assess Adverse Events and Effectiveness of IntraVenous Infusions of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Recruiting
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants. ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/01/2025
Locations: Academic Medical Research Institute - Los Angeles /ID# 270502, Los Angeles, California +15 locations
Conditions: Autosomal Dominant Polycystic Kidney Disease
Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
Recruiting
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult Patients With Moderate to Severe Hidradenitis Suppurativa
Recruiting
The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/01/2025
Locations: Total Skin and Beauty Dermatology Center PC, Birmingham, Alabama +96 locations
Conditions: Hidradenitis Suppurativa
A Study to Investigate Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis
Recruiting
The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/01/2025
Locations: University of Alabama at Birmingham (UAB) - Medical Center, Birmingham, Alabama +48 locations
Conditions: Moderate Aortic Valve Stenosis