Matching Perfusion and Metabolic Activity in HFpEF
Recruiting
This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Heart Failure With Preserved Ejection Fraction
Behavioral Intervention to Reduce Stress Among Black Gender Minority Women
Recruiting
The research objectives of this study are to first, develop a culturally informed community-based intervention with guidance from community members (via focus groups and theater testing) to reduce the effect of chronic stigma exposure on psychological distress symptoms (PTS and depressive symptoms) among transgender women. Second, the research team will conduct a proof-of-concept trial to determine the feasibility and preliminary efficacy of the resulting intervention.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
05/21/2025
Locations: Emory University School of Nursing, Atlanta, Georgia
Conditions: Psychological Distress, Stigma, Social
A Study of CDX-1140, a CD40 Agonist, in Combination With Capecitabine and Oxaliplatin (CAPOX) and Keytruda in Subjects With Biliary Tract Carcinoma (BTC)
Recruiting
Background: Biliary tract carcinoma (BTC) is cancer of the slender tubes that carry fluids in the liver. People with advanced BTC have few treatment options, and their survival rates are very low. Objective: To test a study drug (CDX-1140) combined 3 other drugs (capecitabine, oxaliplatin, Keytruda) in people with BTC. Eligibility: Adults aged 18 years or older with BTC that progressed after treatment and is not eligible for surgery or liver transplant. Design: Participants will be screen... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
05/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Biliary Cancer, Bile Duct Cancer, Cancer of the Bile Duct
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
Recruiting
The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and tolerance for solid food (GI-2 recovery) following bowel resection surgery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: UC Irvine Medical Center, Orange, California
Conditions: Intestinal Disease
A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections
Recruiting
This study is designed to assess the comparative clinical utility of the point of care cobas® liat CT/NG/MG to current standard practices in the diagnosis and treatment of urogenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: San Francisco City Clinic, San Francisco, California +3 locations
Conditions: Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Mycoplasma Genitalium Infection
A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies
Recruiting
This study is a Phase 1 dose-escalation and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV111. The study will enroll patients with relapsed/refractory large B-cell lymphoma (LBCL) and chronic lymphocytic leukemia (CLL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: City of Hope, Duarte, California +5 locations
Conditions: Lymphoma, B-Cell, Lymphoma, Non-Hodgkin (NHL), Lymphoma, Large B-Cell, Diffuse (DLBCL), Chronic Lymphocytic Leukemia (CLL)
A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
Recruiting
The main objective of this study is to evaluate treatment outcomes of tezepelumab among participants with physician-determined surgery-eligible CRSwNP, with or without asthma. Study details include: 1. The study duration will be up to 40 weeks. 2. The treatment duration will be up to 24 weeks. 3. The visit frequency will be once every 4 weeks (Q4W).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
05/21/2025
Locations: Research Site, Newport Beach, California +44 locations
Conditions: Chronic Rhinosinusitis With Nasal Polyps
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With RO7790121 in Participants With Moderately to Severely Active Crohn's Disease
Recruiting
This Phase III, multicenter, double-blind, placebo-controlled treat-through study will evaluate the efficacy and safety of induction and maintenance therapy with RO7790121 in participants with moderately to severely active Crohn's disease (CD).
Gender:
ALL
Ages:
Between 16 years and 80 years
Trial Updated:
05/21/2025
Locations: Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan, Dothan, Alabama +81 locations
Conditions: Moderately to Severely Active Crohns Disease
BOLSTER: Learning New Skills to Thrive
Recruiting
This research study is evaluating a new program called Building Out Lifelines for Safety, Trust, Empowerment, and Renewal or (BOLSTER), which was designed to support participants with a gynecological or gastrointestinal cancer and new and complex care needs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Gastrointestinal Cancer, Gynecologic Cancer, Advanced Cancer
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors
Recruiting
This pilot clinical trial studies how well electrocorticography works in mapping functional brain areas during surgery in patients with brain tumors. Using a larger than the standard mapping grid currently used during brain tumor surgery or a high-definition grid for electrocorticogram brain mapping may help doctors to better identify which areas of the brain are active during specific limb movement and speech during surgery in patients with brain tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Brain Neoplasm
Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer
Recruiting
The purpose of this research study is to test the safety of Niraparib and dostarlimab as a combination treatment and see what effects (good and bad) this combination treatment has on patients with recurrent or progressive cervix cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana +3 locations
Conditions: Recurrent Cervix Cancer, Progressive Cervix Cancer
A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies
Recruiting
Background: Tumors in the genitourinary tracts can occur in the kidney, bladder, prostate, and testicles and can have common and rare histologies. Some cancers that occur along the genitourinary (GU) tract are rare. Some GU tumors are so rare that they are not included in treatment studies or tissue banks. This makes it hard for researchers to determine standards of care. Researchers want to learn more about common and rare GU tumors. Objective: To learn more about urinary tract cancers. Eli... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Urothelial Cancer, Bladder Cancer, Genitourinary Cancer, Urogenital Neoplasms, Urogenital Cancer