STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer
Recruiting
The goal of this clinical trial is to is to investigate if it is possible to lower the chance of cancer reoccurrence and also preserve quality of life by using the drug Pluvicto instead of androgen-deprivation therapy to the usual radiation therapy for advanced local prostate cancer. Participants will receive one dose of Pluvicto, followed by radiation about 6 weeks later. Radiation therapy will be completed in 5 treatments over the period of 2 weeks. A second dose of Pluvicto will be given 6 w... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: University Hospitals Cleveland Medical Center Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Malignant Neoplasm of Prostate, Locally Advanced Prostate Cancer
Exploring Neurophysiological Markers of Brain Health
Recruiting
The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health. In this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).
Gender:
ALL
Ages:
Between 22 years and 100 years
Trial Updated:
05/21/2025
Locations: Center for BrainHealth at The University of Texas at Dallas, Dallas, Texas
Conditions: Healthy Lifestyle, Health-Related Behavior
Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Complex Aortic Aneurysms
Recruiting
The primary objective of the clinical investigation "Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Complex Aortic Aneurysms" is to assess the use of the Physician-Modified Endovascular Grafts to repair juxtarenal aneurysms in high-risk subjects considered to be high risk candidates for open surgical repair, have limited or no other options for on label treatment with an FDA approved device, and having appropriate anatomy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Juxta Renal Abdominal Aortic Aneurysm Without Rupture, Complex Aortic Aneurysms, Aortic Aneurysm
Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
Recruiting
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main questions it aims to answer are: 1. Does at-home transcranial direct current stimulation (tDCS) reduce daily pain intensity in women with endometriosis? 2. Does the device also improve mood and slee... Read More
Gender:
FEMALE
Ages:
Between 22 years and 45 years
Trial Updated:
05/21/2025
Locations: Alethios, Inc., San Francisco, California
Conditions: Endometriosis
Laboratory Study of Cancer & Immune Cells in Ascites Fluid of Ovarian Cancer Patients to Test Alternative Therapies
Recruiting
Ascites samples from women undergoing surgery for ovarian cancer will be collected for use in translational research.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University of New Mexico Cancer Center, Albuquerque, New Mexico
Conditions: Ovarian Cancer
Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer
Recruiting
This research study is being done to help determine the safety and efficacy of gadolinium based nanoparticle, Activation and Guidance of Irradiation X (AGuIX), used in conjunction with MR-guided stereotactic body radiation therapy (SBRT) in the treatment of pancreatic cancer and lung tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Non-small Cell Lung Cancer, Advanced Pancreatic Adenocarcinoma, Unresectable Pancreatic Cancer, Ductal Adenocarcinoma of the Pancreas
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
Recruiting
African Americans (AAs) have rates of diabetes mellitus (DM) twice that of Whites and are disproportionately affected by leading risk factors for DM - obesity and low-income. A critical strategy in the battle against DM is the Diabetes Prevention Program (DPP), an evidence-based intervention that significantly delays or prevents Type 2 diabetes through the promotion of diet change, exercise and modest weight loss. However, weight loss from the DPP among AAs is about half that of White participan... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University Health, Kansas City, Missouri +1 locations
Conditions: PreDiabetes, Overweight and Obesity
A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia
Recruiting
The purpose of this study is to evaluate efficacy and safety of ianalumab compared to placebo in patients with warm autoimmune hemolytic anemia, who failed at least one line of treatment.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/20/2025
Locations: University of Colorado Anschutz, Aurora, Colorado +88 locations
Conditions: Warm Autoimmune Hemolytic Anemia (wAIHA)
Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study
Recruiting
This phase II trial studies how well giving testosterone at levels higher than normally found in the body (supraphysiological) works to enhance chemotherapy treatment, and Lutetium 177Lu-prostate specific-membrane antigen (PSMA)-617 (LuPSMA) in patients with prostate cancer that has progressed despite being previously treated with androgen therapies and has spread from where it first started (prostate) to other places in the body (metastatic castration-resistant prostate cancer). In patients tha... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
Recruiting
The main purpose of this study is to evaluate the safety and efficacy of LY3541860 in adult participants with multiple sclerosis that gets worse and gets better. The study will last about 9 months with additional 6 months follow-up.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/20/2025
Locations: Healthcare Innovations Institute, LLC, Coral Springs, Florida +53 locations
Conditions: Multiple Sclerosis
Delta GREENS Food is Medicine Intervention
Recruiting
Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/20/2025
Locations: Tufts University, Boston, Massachusetts
Conditions: Cardiometabolic Risk Factors, Diabetes, High Blood Pressure, Obesity, Nutrition Security
A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 2
Recruiting
The purpose of this study is to measure the safety and decrease in sleepiness in subjects with narcolepsy type 2 (NT2) when taking ALKS 2680 tablets compared to placebo tablets.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/20/2025
Locations: Alkermes Investigator Site, Little Rock, Arkansas +44 locations
Conditions: Narcolepsy Type 2