Stage II/III Colorectal Cancer Recurrence
NCT06314958
Recruiting
This study will develop an assay to predict disease recurrence in patients with stage II/III CRC after receiving adjuvant chemotherapy, using genome-wide DNA methylation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: City of Hope Medical Center, Monrovia, California +3 locations
Conditions: Colorectal Cancer, Colorectal Adenocarcinoma, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Cancer Recurrent
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Project Mountain - Comparing SpO2 and SaO2 for Accuracy
NCT06372106
Recruiting
The main goal of this study is to look at the performance of the neonatal, infant, and pediatric Philips SpO2 sensors with the Philips FAST Pulse Oximetry technology. Oxygen saturation measurements (SpO2) will be obtained via pulse oximetry and invasive arterial oxygen measurements (SaO2) will be obtained via arterial blood samples as part of your clinical care and assessed by co-oximetry. The study will aim to enroll a diverse population to help us understand the impact of skin pigmentation.
Gender:
ALL
Ages:
All
Trial Updated:
04/01/2025
Locations: Phoenix Children's, Phoenix, Arizona +4 locations
Conditions: SpO2, Nasal Alar Collapse, Bilateral, Oxygen, Measurement
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A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
NCT06481891
Recruiting
The main purpose of the study is to determine the changes in symptoms and functional limitations in participants with symptomatic hypertrophic cardiomyopathy (HCM) treated with sotagliflozin as compared to placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Lexicon Investigational Site (4037), Scottsdale, Arizona +21 locations
Conditions: Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy
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Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients
NCT06539468
Recruiting
This clinical trial evaluates whether active surveillance (AS) is a safe and comfortable alternative to standard of care (SOC) treatment for elderly patients with low-risk basal cell carcinoma (LR-BCC). Basal cell carcinoma is a type of slow-growing skin cancer that has a very low risk of spreading inside the body (metastasis) or death. Basal cell skin cancers that are smaller across than a nickel in size and located on the trunk or limbs are particularly low risk to overall health. Active surve... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/01/2025
Locations: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Skin Basal Cell Carcinoma
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Effect of Cannabis on E-Cigarette Use Behavior
NCT06609109
Recruiting
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke e-cigarettes and either smoke or vape THC in the laboratory.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/01/2025
Locations: Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Cannabis Use, Tobacco Use, Electronic Cigarette Use
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A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56
NCT06668064
Recruiting
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/01/2025
Locations: Retinal Research Institute, LLC, Phoenix, Arizona +78 locations
Conditions: Wet Age Related Macular Degeneration, wAMD
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Collaborate and Leverage Evidence in African American Rural Network
NCT06730633
Recruiting
The goal of this non-randomized, propensity-matched-controlled study is to assess the effectiveness of the Heart Matters evidence-based program -- previously evaluated for feasibility and efficacy in NCT02707432 -- in improving cardiovascular health outcomes (change in systolic and diastolic blood pressure, primary outcomes) when implemented by community-based facilitators.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: A Better Chance, A Better Community, Enfield, North Carolina +8 locations
Conditions: Cardiovascular Diseases
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A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia
NCT06843590
Recruiting
The purpose of this study is to measure the safety and decrease in daytime sleepiness in subjects with Idiopathic Hypersomnia when taking ALKS 2680 tablets compared with placebo tablets
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/01/2025
Locations: Alkermes Investigational Site, Huntersville, North Carolina +1 locations
Conditions: Idiopathic Hypersomnia
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Digital Support Strategies for Caregiver Home Practice
NCT06907966
Recruiting
This project is a pilot trial of the Engaging Families home practice smartphone application (or "app") as an add on to a family-based prevention program. Although there are many evidence-based preventive interventions delivered to caregivers to prevent youth substance use and mental illness and promote youth positive family and youth outcomes, the impact of these interventions is often limited by low home practice of intervention skills among caregivers. The Engaging Families home practice app i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Acceptability, Feasibility Studies
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Effect of Peanut Butter on Gut and Metabolic Health
NCT06916936
Recruiting
The goal of this is parallel arm, randomized clinical trial is to learn and understand the effect of daily smooth peanut butter consumption on gut and metabolic health of children age 6-13. The main objectives are: Primary Objective: To determine the prebiotic effect of daily smooth peanut butter consumption for eight weeks on gut health, including microbiome-metabolome arrays, gut epithelial/barrier function, and gut transit time, in school-aged children. Secondary Objective(s) 1. To determi... Read More
Gender:
ALL
Ages:
Between 6 years and 13 years
Trial Updated:
04/01/2025
Locations: Florida State Univresity - The Gut Biome Lab, Tallahassee, Florida
Conditions: Dysbiosis
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Repository of Novel Analytes Leading to Autoimmune, Inflammatory and Diabetic Nephropathies (RENAL AID)
NCT01802034
Recruiting
A central goal of this data repository is to collect data from a large population of subjects with a variety of renal disease states. Cohorts will include subjects with diabetes, inflammatory/autoimmune and transplant related renal conditions. Additionally, the repository will have the capacity to store biospecimens and electronic data in control subjects without established renal disease. This initiative will provide an opportunity to compare data from various disease states and controls with t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: The Rogosin Institute, New York, New York
Conditions: Kidney Diseases, Kidney Failure, Chronic, Diabetic Nephropathy, Lupus Nephritis, Glomerulonephritis, IGA
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Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies
NCT03610802
Recruiting
Background: The immune system helps the body fight infections. Primary immunodeficiency disorders (PIDs) are diseases that make it easier for people to get sick. Many PIDs are inherited. This means parents can pass them on to their children. Knowing what causes a person s PID is important to decide what treatment to give them. Objective: To test samples from people with a PID or people related to someone with a PID to find out what causes PIDs. Eligibility: People ages 99 or younger who hav... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
04/01/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland +2 locations
Conditions: Primary Immunodeficiency
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