Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia
NCT06376162
Recruiting
The primary objective of the study is to determine the recommended phase 2 dose (RP2D) of ziftomenib in combination with chemotherapy (FLA) in children with relapsed or refractory KMT2A-r, NUP98-r, or NPM1-m acute leukemia based on safety and pharmacokinetics (PK).
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
05/20/2025
Locations: Children's Hospital Colorado, Aurora, Colorado +14 locations
Conditions: Relapsed/Refractory KMT2A-r Acute Leukemia, Relapsed/Refractory NUP98-r Acute Leukemia, Relapsed/Refractory NPM1-m Acute Leukemia
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Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age
NCT06582056
Recruiting
The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study. Participants will be categorized based on point-of-care hemoglobin A1c (HbA1c) and periodontal disease (PD) staging into 9 subgroups. The key objectives of the study are: * To evaluate immune signatures in well-characterized populations with or without PD and/or T2DM * To evaluate baseline clinical biomarkers of T2DM an... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
05/20/2025
Locations: University of Iowa - Site Number : 8400002, Iowa City, Iowa +3 locations
Conditions: Periodontal Disease
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CART123 + Ruxolitinib in Relapsed/Refractory AML
NCT06768476
Recruiting
Phase I, open-label study to assess the safety, feasibility, pharmacokinetics, and preliminary efficacy of CART123 cells given in combination with ruxolitinib in patients with relapsed or refractory acute myeloid leukemia (AML). All subjects will receive a single infusion of CART123 cells following ruxolitinib administration and lymphodepletion. Ruxolitinib dosing will begin at initiation of lymphodepleting chemotherapy (Day -6 ±1d) and continue for up to 14 days post CART123 administration.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Relapsed AML, Refractory AML
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Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders
NCT06926036
Recruiting
This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake. Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subseque... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/20/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Sleep Apnea Obstructive (OSA)
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Weight Management Intervention in College: A Pilot RCT
NCT06994923
Recruiting
This pilot randomized controlled trial will examine a behavioral weight loss intervention that uses a "small change" approach fro emerging adult college students with overweight/obesity. The primary aim is to assess student acceptability and clinically-meaningful weight changes.
Gender:
ALL
Ages:
Between 18 years and 29 years
Trial Updated:
05/20/2025
Locations: The Miriam Hospital, Providence, Rhode Island
Conditions: Obesity and Overweight
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S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
NCT04155034
Recruiting
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +445 locations
Conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma
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Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
NCT05011045
Recruiting
This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hematologic malignancies). This may help researchers learn more about the effects of whole brain radiation therapy on memory and thinking in patients with blood cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Central Nervous System Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm, Leukemia, Lymphoma, Plasma Cell Myeloma, Secondary Central Nervous System Lymphoma
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A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
NCT05395481
Recruiting
The main purpose of this study is to evaluate the safety and tolerability of the study drug LY3849891 in participants with metabolic dysfunction-associated steatotic liver disease (MASLD) who have the patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M genotype. Blood tests and magnetic resonance imaging of the liver will be performed to determine the effects of LY3849891 on MASLD and assessment of resolution of liver fibroinflammation. Blood tests will also determine how long... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/20/2025
Locations: Arizona Liver Health - Chandler, Chandler, Arizona +15 locations
Conditions: Metabolic Dysfunction-Associated Steatohepatitis (MASH), Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)
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Journey of Transformation Curriculum for Native American Youth
NCT05731713
Recruiting
The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and improving sexual health.
Gender:
ALL
Ages:
Between 13 years and 16 years
Trial Updated:
05/20/2025
Locations: University of Washington, Seattle, Washington
Conditions: Alcohol Drinking, Tobacco Use, Substance Use, Sexual Behavior
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Daratumumab for Polyneuropathy Associated With MGUS
NCT06046287
Recruiting
The goal of this clinical trial is to learn about daratumumab and hyaluronidase-fihj in patients with monoclonal gammopathy of undetermined significant (MGUS) who have been diagnosed with peripheral neuropathy suspected to be cause by paraproteinemia. The main question\[s\] it aims to answer are: • how well does this medication help improve MGUS associated peripheral neuropathy Participants will be asked be asked to get some testing done prior to starting the trial in order for us to assess yo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia +1 locations
Conditions: Peripheral Neuropathy, Monoclonal Gammopathy of Undetermined Significance
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Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
NCT06242704
Recruiting
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area. Results from the study will inform future substance use prevention efforts targeted at youth exposed to adverse childhood experiences. Findings will also refine future models of intervention delivery in traditionally underserved communities. The main aims of the project are are... Read More
Gender:
ALL
Ages:
11 years and above
Trial Updated:
05/20/2025
Locations: Freedom Schools Collaborative, Flint, Michigan +1 locations
Conditions: Behavior, Health
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Quantifying Patellar Tendon Microstructure Using DTI
NCT06381492
Recruiting
The goal of this observational study is to understand how diffusion tensor imaging (DTI) relates to other traditional measures and knee function. The main question it aims to answer is: Will regions of known patellar tendon pathology present with smaller DTI scalar parameters, shorter fiber length, and lower fiber density compared to the contralateral tendon and healthy regions in the ipsilateral tendon. Participants will: * undergo MRI and ultrasound imaging * perform knee function test * co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Patellar Tendinopathy, Anterior Cruciate Ligament Reconstruction
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