Ultrasound Analysis of Human Carpal Tunnel System
NCT02747836
Recruiting
This study evaluates the ability of ultrasound to measure the movement of tendons and nerves within the human carpal tunnel.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/31/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Carpal Tunnel Syndrome
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LITES Task Order 0005 Prehospital Airway Control Trial (PACT)
NCT04100564
Recruiting
The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outcomes to include survival to hospital discharge, expected clinical adverse events, airway management per... Read More
Gender:
ALL
Ages:
15 years and above
Trial Updated:
03/31/2025
Locations: Emory University, Atlanta, Georgia +13 locations
Conditions: Trauma Injury, Airway Control
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Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
NCT04419272
Recruiting
Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of attention deficit hyperactivity disorder (ADHD). It is unknown, however, if stimulants would be of benefit for memory and thinking problems due to epilepsy. In this study, participants will be assigned randomly (i.e., by flip of a coin), to a group that takes MPH and a group that takes a placebo (sugar pill). Participants will not know the group to which they have been assigned. Tests of attention and memory will be complete... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Miami VA Healthcare System, Miami, FL, Miami, Florida +3 locations
Conditions: Epilepsy
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A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
NCT05130437
Recruiting
The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).
Gender:
ALL
Ages:
1 year and above
Trial Updated:
03/31/2025
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California +8 locations
Conditions: Propionic Acidemia
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PTSD Treatment for Incarcerated Men and Women: WPP
NCT05432817
Recruiting
Study examining the psychological response to group Cognitive Processing Therapy (CPT) in incarcerated men and women with Post-traumatic stress disorder (PTSD). The study will be conducted in male and female incarcerated populations and will include 2 groups of individuals for both CPT and waitlist control in both populations (140 participants total).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Psychiatric Institute and Clinic, Madison, Wisconsin
Conditions: PTSD
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Randomized Trial of EUS-guided Gastrojejunostomy and Surgical Gastrojejunostomy in Gastric Outlet Obstruction
NCT05548114
Recruiting
Malignant gastric outlet obstruction (GOO) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer. The consequences of GOO are abdominal pain, nausea, vomiting, anorexia, inability to maintain an oral diet and weight loss, with associated poor quality of life and inability to continue with cancer therapy. The aim of this study is to compare the clinical outcomes between surgical gastrojejunostomy and EUS-guided gastrojejunostomy in patients with malig... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Orlando Health, Orlando, Florida
Conditions: Gastric Outlet Obstruction
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Busulfan Sample Collection Study
NCT05711732
Recruiting
Busulfan (Busulfex®) is an alkylating drug used as a conditioning regimen prior to allogeneic hematopoietic stem cell transplantation. Busulfan has wide inter- and intra-patient pharmacokinetic variability resulting in variable exposure leading to increased risk of toxicities or sub-optimal treatment outcomes. Therapeutic drug monitoring of busulfan using patient plasma samples would benefit clinicians by providing the ability to personalize the dose to achieve a target busulfan exposure.
Gender:
ALL
Ages:
All
Trial Updated:
03/31/2025
Locations: Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois +1 locations
Conditions: Subjects Treated With Busulfan
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Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
NCT05790252
Recruiting
The goal of this clinical trial is to compare buprenorphine patch for induction (starting) of buprenorphine in pregnant patients with opioid use disorder. The main questions it aims to answer are: 1. Is there a buprenorphine induction method that results in the least moderate-to-severe opioid withdrawal symptoms in pregnant patients with opioid use disorder? 2. Is there a buprenorphine induction method that results in a higher treatment success rate? Under normal circumstances, patients who are... Read More
Gender:
FEMALE
Ages:
Between 18 years and 110 years
Trial Updated:
03/31/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Opioid Use Disorder, Pregnancy Related, Pregnancy, High Risk, Pregnancy Complications, Buprenorphine Withdrawal
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A Study of Pulmonary Hypertension Peripheral Limitations
NCT05968859
Recruiting
The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Pulmonary Arterial Hypertension, Healthy
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A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults
NCT06047444
Recruiting
The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic migraine. A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head, and is often accompanied by feeling or being sick and a sensitivity to bright lights and sound. Chronic migraine is defined as having at least 15 days of headache a month with at least 8 of those days being migraine headache day... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Central Research Associates, Birmingham, Alabama +111 locations
Conditions: Chronic Migraine
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AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
NCT06137118
Recruiting
This is a Phase 1/2, global multicentre, open-label, single-arm, dose escalation and dose optimisation study of AZD0486 to evaluate the safety, tolerability, and efficacy of AZD0486 monotherapy in participants with R/R B ALL who have received ≥ 2 prior lines of therapies. The study will consist of 3 parts. Part A monotherapy dose escalation. Part B dose optimisation. Part C Dose expansion at the recommended phase 2 dose (RP2D)
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
03/31/2025
Locations: Research Site, Birmingham, Alabama +61 locations
Conditions: B-cell Acute Lymphoblastic Leukemia (B-ALL)
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Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
NCT06236100
Recruiting
Primary Objective: Conduct a rigorous evaluation of a prevention-based intervention designed to mitigate the harms of adverse childhood experiences (ACEs) exposure and prevent future ACEs, substance use, and overdose within 36 communities experiencing a disproportionate burden of substance use and ACEs. The study has three aims: (1) use a cluster randomized controlled trial to test effectiveness of the Strengthening Families Program (SFP) + Family Advocate (FA) intervention on substance use, ov... Read More
Gender:
ALL
Ages:
7 years and above
Trial Updated:
03/31/2025
Locations: New Jersey Prevention Network, Tinton Falls, New Jersey
Conditions: Substance-Related Disorders, Adverse Childhood Experiences
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