FaCT Trial (Facilitated Cascade Testing Trial)
NCT04613440
Recruiting
The purpose of this study is to assess an intervention that incorporates engagement strategies with a medical team navigator, an educational video and accessible genetic testing services to maximize the genetic testing and education of at-risk relatives. In this study, first degree relatives who agree to participate will either receive this intervention or standard of care. The investigators do not know if the facilitated interventional method will be more effective than the standard of care met... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Weill Cornell Medicine, New York, New York +2 locations
Conditions: BRCA1 Mutation, BRCA2 Mutation
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Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
NCT04623541
Recruiting
The study is a global, multi-center safety and efficacy trial of epcoritamab, an antibody also known as EPKINLY™ and GEN3013 (DuoBody®-CD3xCD20). Epcoritamab will be tested either in Relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) as: * Monotherapy, or * Combination therapy: * epcoritamab + venetoclax * epcoritamab + pirtobrutinib In Non-United States (US) Participants Only: Treatment-naïve (TN) high risk (HR) (CLL): • epcoritamab + pirtobrutinib Combination therapy for Ri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, Alabama +86 locations
Conditions: Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Treatment-naïve High Risk Chronic Lymphocytic Leukemia, Richter's Syndrome
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General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19
NCT04626050
Recruiting
It is expected that large numbers of healthcare workers will experience a broad range of psychological reactions and symptoms including anxiety, depression, moral distress, and trauma symptoms that will cause both significant suffering as well as occupational and social impairment. The purpose of this study is to find interventions which are helpful in treating psychological distress in healthcare workers caring for COVID-19 patients. There are two phases of the study. All participants will tak... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Post-traumatic Stress Disorder, Moral Injury
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Mechanistic Interventions and Neuroscience of Dissociation
NCT04670640
Recruiting
The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: Grady Hospital, Atlanta, Georgia +1 locations
Conditions: Dissociation
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Virtual Reality for Pain Management in Burn Patients
NCT04685486
Recruiting
This study is a randomized proof-of-concept study to assess the efficacy of Virtual Reality (VR) vs standard of care in 50 adult patients in the New York Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the standard of care and is known to be effective. Participants will be randomly assigned to two groups. The first group will receive VR during their painful procedure (e.g., wound dressing changes, physica... Read More
Gender:
ALL
Ages:
8 years and above
Trial Updated:
07/30/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Pain
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Baloxavir and Oseltamivir for the Treatment of Severe Influenza Infection in Immunocompromised Patients
NCT04712539
Recruiting
This phase II trial studies the effect of baloxavir in combination with oseltamivir in treating severe influenza infection in patients who have previously received a hematopoietic (blood) stem cell transplant or have a hematological malignancy. Baloxavir is an antiviral drug that inhibits the growth of influenza virus, reduces viral load and prevents further influenza infection. Osetamivir is an antiviral drug that blocks enzymes on the surfaces of influenza viruses, interfering with cell releas... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/30/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Influenza
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Beta-blocker Administration for Cardiomyocyte Division
NCT04713657
Recruiting
Heart failure is a common long-term complication in patients with congenital heart disease (CHD). Medical treatments to promote regeneration of new healthy heart muscle cells have the potential to provide new heart failure treatments for these patients. The development of such therapies is limited by the poor understanding of the ways in which heart muscles grow after birth. Investigators have learned that humans without heart disease generate new heart muscles cells up to the age of 20 years ol... Read More
Gender:
ALL
Ages:
Between 30 days and 60 days
Trial Updated:
07/30/2025
Locations: Weill Cornell Medicine, New York, New York +2 locations
Conditions: Tetralogy of Fallot, Double Outlet Right Ventricle
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Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
NCT04723862
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
07/30/2025
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
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PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2
NCT04815876
Recruiting
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a much lower risk of infection, comparable pain/discomfort and may improve detection of prostate cancer. This randomiz... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Southern California, Los Angeles, California +15 locations
Conditions: Infection
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First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients
NCT04858269
Recruiting
The purpose of this research is to see what effects the treatment regimen chemotherapy (carboplatin and paclitaxel) plus immunotherapy (pembrolizumab), has on patients who have been diagnosed with head/neck squamous cell carcinoma and are unable to take the drug 5-fluorouracil
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Wake Forest Baptist Health Sciences, Winston-Salem, North Carolina
Conditions: Head Neck Cancer, Metastatic Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma, Hypopharynx Squamous Cell Carcinoma, Larynx Squamous Cell Carcinoma
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A Comparative Analysis of REVOLVE, LipoGrafter, and Viality in Autologous Fat Grafting During Breast Surgery
NCT04891510
Recruiting
The purpose of this study is to learn whether there is a superior fat processing method in terms of graft retention in breast reconstruction after mastectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: New York Presbyterian - Weill Cornell Medicine, New York, New York
Conditions: Mastectomy, Mammaplasty, Breast Reconstruction
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NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers
NCT04896775
Recruiting
The goal of this project evaluate the efficacy of NiteCAPP in improving insomnia in a rural dementia caregiver sample (n of 100 caregiver and PWD dyads). We will measure both the short term (post-treatment) and long term (6 and 12 months) effects of the intervention on CG sleep, arousal, inflammation, health, mood, burden and cognitive function, and PWD sleep.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of South Florida, Tampa, Florida
Conditions: Insomnia, Dementia
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