Tranexamic Acid in Reducing Blood Loss in Patients With Pelvic Tumors Undergoing Hemipelvectomy Surgery
NCT03128866
Recruiting
This early phase I trial studies how well tranexamic acid works in reducing the loss of blood in patients with pelvic tumors undergoing hemipelvectomy surgery. Tranexamic acid decreases blood loss by stabilizing clots and preventing clot lysis in patients undergoing surgery.
Gender:
ALL
Ages:
All
Trial Updated:
03/27/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Pelvic Mass
Register for Updates
Trial of Ixazomib for Kaposi Sarcoma
NCT04305691
Recruiting
This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UC San Diego, San Diego, California +7 locations
Conditions: Kaposi Sarcoma, Skin
Register for Updates
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
NCT05530317
Recruiting
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with confirmed SARS-CoV-2 infection, symptoms not present prior to COVID-19 that are persistent for at least 3 months after acute infection ("Long COVID"), and who have reduced exercise capacity less than predicted and reduced heart rate response during cardiop... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Long COVID, COVID-19
Register for Updates
CANF-Comb-II PET-MR in Atherosclerosis Multisite
NCT05838547
Recruiting
The goal of this observational study is to learn more about plaque biology in asymptomatic carotid artery stenosis (ACAS) patients through imaging. The main questions it aims to answer are: * To determine the ability of 64Cu-CANF-Comb positron emission tomography (PET) to risk stratify ACAS patients for stroke event, to include transient ischemic attack or remote ipsilateral intervention. * To further understand the role of Natriuretic Peptide Receptor C (NPRC) in the evolution of carotid ather... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California +1 locations
Conditions: Carotid Atherosclerosis, Asymptomatic Carotid Artery Stenosis, Carotid Artery Atheroma
Register for Updates
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
NCT06225596
Recruiting
This is a global, multicenter, randomized, open-label study, with an adaptive design. The main objective of the study is to measure the efficacy and safety of BT8009 (zelenectide pevedotin) as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic urothelial cancer (UC). The study includes a dose selection phase followed by an adaptive design continuation. The study is comprised of 2 cohorts. Cohort 1 will include participants who have not received... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +169 locations
Conditions: Metastatic Urothelial Cancer
Register for Updates
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
NCT06538311
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured wit... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
03/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic Symptoms
Register for Updates
Tissue Repair Gel in Venous Leg Ulcers in AU/US
NCT06707103
Recruiting
The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs). It will also provide additional information about the safety of drug TR987 0.1% gel.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Clincial Research Site 92, Jacksonville, Florida +11 locations
Conditions: Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis, Wound Heal, Wound, Venous Insufficiency of Leg, Non-healing Wound
Register for Updates
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Atopic Dermatitis
NCT06863961
Recruiting
The purpose of this study is to assess the efficacy and safety of RO7790121 in participants with moderate to severe atopic dermatitis (AD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Dermatology Research Associate, Los Angeles, California +3 locations
Conditions: Atopic Dermatitis
Register for Updates
The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring
NCT03155854
Recruiting
Research is instrumental for improving medical care and the patient experience. Finding new surgical techniques can create better outcomes and minimize recovery time and complications for patients. Some patients undergoing trigger finger surgery with a pre-existing Dupuytren's cord may develop a thickened surgical scar after surgery, which can cause discomfort, difficulty with moving or using, and other complications in the affected finger(s) or hand. The investigator is investigating a surgical... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Dupuytren Contracture
Register for Updates
Intervention to Improve Driving Practices Among High-Risk Teen Drivers
NCT04317664
Recruiting
The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent communication training, on risky driving events, unsafe driving behaviors, and subsequent traffic violations among teens who have recently received a moving traffic violation.
Gender:
ALL
Ages:
Between 16 years and 17 years
Trial Updated:
03/27/2025
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Drive, Recidivism, Communication, Feedback, Psychological
Register for Updates
Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
NCT05540106
Recruiting
The objective of this research is to assess the effects of engaging in coloring activities on patients' self-reported pain and anxiety scores while they wait to be seen by a physician in an emergency department (ED). The current literature on patient visits in the ED highlights the significance of anxiety, stress, and frustration in patient experiences, especially when accounting for long wait times before the physician-patient encounter. The study will address this common problem by looking at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Stony Brook University Hospital, Stony Brook, New York
Conditions: Anxiety, Pain
Register for Updates
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
NCT05838560
Recruiting
This pilot open-label study examines the effects of a combination of dasatinib plus quercetin - two drugs that have known senolytics properties - on physiological aging in older individuals with depression or schizophrenia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/27/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Schizophrenia, Treatment Resistant Depression, Aging, Premature
Register for Updates