Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging
NCT06123182
Recruiting
The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out. Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
04/10/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Exercise Training, Aging
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A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
NCT06254950
Recruiting
The main aim of this study is to learn if TAK-279 reduces bowel inflammation and symptoms compared to placebo. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate any problems. The participants will take capsules of either TAK-279 or placebo for up to 3 months (12 weeks). Then all the participants will receive TAK-279 for the rest of the treatment part of the study (1 year or 52 weeks). During the study,... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/10/2025
Locations: GastroIntestinal BioSciences, Los Angeles, California +176 locations
Conditions: Ulcerative Colitis
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Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter
NCT06359379
Recruiting
This is a randomized, open-label, phase 2 study evaluating the safety and efficacy of oral ropidoxuridine as a radiation-sensitizing agent in patients with newly diagnosed wild-type isocitrate dehydrogenase glioblastoma with an unmethylated O6-methylguanine-DNA methyltransferase promoter, undergoing standard 60 Gy radiotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Lombardi Comprehensive Cancer Center, Washington, District of Columbia +5 locations
Conditions: Glioblastoma, IDH-wildtype
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Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
NCT06462365
Recruiting
The purpose of this Phase 1, first in human open-label study is to assess the safety and tolerability of TRX-103 in patients with hematological malignancies undergoing HLA-mismatched related or unrelated hematopoietic stem cell transplantation (HSCT). It is anticipated that up to 36 Subjects will be enrolled during a 18-24 month enrollment period. TRX-103 will be infused one time post HSCT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: City of Hope, Duarte, California +4 locations
Conditions: Hematologic Malignancy, GvHD, GVHD,Acute, GVHD, Chronic, Hematopoietic Stem Cell Transplant, Acute Lymphoblastic Leukemia, Adult B-Cell, Acute Lymphoblastic Leukemia, Adult T-Cell, Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, in Remission, Cancer Remission
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Effectiveness of Phenazopyridine for Pain Following Urodynamics
NCT06577493
Recruiting
The purpose of the study is to determine if taking phenazopyridine (AZO) at the time of urodynamic study testing will decrease pain experienced by patients after undergoing urodynamic testing.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
04/10/2025
Locations: University of South Florida South Tampa Center, Tampa, Florida
Conditions: Pain After Urodynamic Testing
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Circadian Mechanisms, Glucose, and CV Risks in T1D
NCT06624046
Recruiting
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance t... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/10/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Type 1 Diabetes (T1D)
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Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)
NCT06699251
Recruiting
Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/10/2025
Locations: AltaMed Health Services, Commerce, California +1 locations
Conditions: Adolescent Drinking, Cannabis Use
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A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function
NCT06734208
Recruiting
This is a phase 1, open-label, single-dose, parallel-cohort study to determine the pharmacokinetics (PK) of divarasib in healthy participants and participants with varying degrees of hepatic impairment, as defined by Child-Pugh classification.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/10/2025
Locations: Orlando Clinical Research Center, Orlando, Florida
Conditions: Hepatic Impairment
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A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors
NCT06803680
Recruiting
The goal of this clinical trial is to learn if BGB-B455 can treat advanced or metastatic solid tumors expressing claudin 6 (CLDN6), a protein that is found on some tumors. The main questions it aims to answer are: * What is the recommended dosing for BGB-B455? * What medical problems do participants have when taking BGB-B455? The study has two parts: * Phase 1a: dose escalation and safety expansion * Phase 1b: dose expansion
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Adventhealth, Celebration, Florida +12 locations
Conditions: Advanced Solid Tumor, Metastatic Solid Tumor
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A Single-dose Study to Evaluate the Safety, Tolerability, Drug Levels, and Relative Biological Availability of Alternate Formulations of BMS-986460 in Healthy Adult Male Participants
NCT06877702
Recruiting
The purpose of this study is to assess the safety, tolerability, drug levels, and relative bioavailability of alternate formulations of BMS-986460 in healthy adult male participants.
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
04/10/2025
Locations: ICON Lenexa, Lenexa, Kansas +1 locations
Conditions: Healthy Volunteers
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Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)
NCT06919991
Recruiting
The purpose of the study is to assess the effects of multiple doses of itraconazole (a strong CYP3A4 inhibitor) on single dose PK of casdatifan in healthy adults and to assess the effects of multiple doses of phenytoin (a strong CYP3A4 inducer) on single dose PK of casdatifan in healthy adults.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/10/2025
Locations: Celerion, Tempe, Arizona
Conditions: Healthy Participants
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Temple Health Chest Initiative (THCI 2.0)
NCT06933758
Recruiting
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare utilization including hospitalization. Population-based screening for COPD has not been recommended by the US Preventative Services Task Force (USPSTF). However, LDCT screening for lung cancer in patients aged 50- 80 with ≥ 20 pack year smoking has been shown to improve... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/10/2025
Locations: Temple University Of the Commonwealth System of Higher Education, Philadelphia, Pennsylvania
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
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