Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Cisplatin-eligible Upper Tract Urothelial Cancer
Recruiting
This trial is a multi-site, single-arm, phase 2 trial of neoadjuvant combination of enfortumab vedotin and pembrolizumab in cisplatin-eligible patients with high-grade localized/locally advanced cT1-4 N0-1 M0 upper tract urothelial cancer who are deemed eligible for curative-intent surgery (radical nephroureterectomy or distal ureterectomy) followed by adjuvant pembrolizumab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Urothelial Carcinoma
A Study of Barzolvolimab in Patients With Prurigo Nodularis
Recruiting
The purpose of this study is to assess the efficacy and safety of barzolvolimab in adults with prurigo nodularis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Total Dermatology, Birmingham, Alabama +57 locations
Conditions: Prurigo Nodularis
Ultrasound Investigation Into Swimming Induced Pulmonary Edema in Open Water Swimming Athletes
Recruiting
Swimming-induced pulmonary edema (SIPE) is a potentially life-threatening condition that can affect swimmers of all abilities. The pathophysiology is not well understood and early identification strategies are not established. Handheld ultrasound is a validated tool for the identification of pulmonary edema and is not well-studied in this population. Understanding the incidence of signs of pulmonary edema and its usefulness as a sign of early pulmonary edema would be beneficial This study evalua... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Rocky Vista University, Parker, Colorado
Conditions: Swimming Induced Pulmonary Edema
A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer
Recruiting
The researchers are doing this study to find out whether the combination of avutometinib, defactinib, and letrozole is an effective treatment for people with low-grade serous ovarian cancer (LGSOC). The researchers will also look at the safety of this combination.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Emory Winship Cancer Institute, Atlanta, Georgia +7 locations
Conditions: Low-Grade Serous Ovarian Cancer
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
Recruiting
This is a prospective, open-label, single arm 3-year clinical study to describe the short-term and long-term efficacy and safety of belimumab in participants with autoantibody positive early SLE with ongoing disease activity despite stable initial SLE therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: GSK Investigational Site, Anniston, Alabama +99 locations
Conditions: Systemic Lupus Erythematosus
M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)
Recruiting
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic profile of M9466 with and without tuvusertib or an ARPi and early signs of clinical activity of M9466 with tuvusertib in participants with advanced solid tumors. Study details include: Study/Treatment Duration: Participants will be treated until disease progression, death, discontinuation, or End of Study. Visit Frequency: Every week in the first 2 cycles, followed by every 3 weeks in the subseque... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: NEXT Oncology - PARENT, New York, New York +18 locations
Conditions: Advanced Solid Tumor
Accelerated rTMS for Substance Use Disorder and Depression
Recruiting
This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder \[including methamphetamine or cocaine use disorder (MUD/CUD)\].
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/28/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Stimulant Use, Depression
ADVENT Post Approval Study
Recruiting
The ADVENT Post Approval Study (PAS) is a prospective, global, multicenter, observational study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Mobile Infirmary Medical Center, Mobile, Alabama +33 locations
Conditions: Paroxysmal Atrial Fibrillation
First-in-human Study of Interferon-y PET Imaging to Assess Response to Immunotherapy
Recruiting
The goal of this clinical trial is to investigate the use of \[89Zr\]Zr-DFO-emapalumab as an IFN-γ PET imaging agent to detect lesions and response to therapy among treatment-naïve non-small cell lung cancer (NSCLC) patients. PET scans following the imaging agent will be completed prior to and about 30 days after starting immunotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Karmanos Cancer Institute, Detroit, Michigan
Conditions: Non Small Cell Lung Cancer
Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
Recruiting
While blood clots after major cancer surgery are common and harmful to patients, the medications to decrease blood clot risk are seldom used after patients leave the hospital despite the recommendation of multiple professional medical societies. The reason why these medications are seldom prescribed is not well understood. The main questions this study aims to answer are: * Does surgeon education paired with an electronic medical record based decision support tool improve the guideline concorda... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis, Cancer, Surgery
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
Recruiting
The purpose of this study is to evaluate efficacy, safety and tolerability of s.c. ianalumab administered in participants with diffuse cutaneous systemic sclerosis relative to placebo
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Arizona Arthritis and Rheumatology Research PLLC, Mesa, Arizona +95 locations
Conditions: Diffuse Cutaneous Systemic Sclerosis
Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL
Recruiting
To evaluate the use of HyBryte, a topical photosensitizing agent, to treat patients with patch/plaque phase cutaneous T-cell lymphoma (mycosis fungoides).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Medical Dermatology Specialists, Phoenix, Arizona +16 locations
Conditions: CTCL/ Mycosis Fungoides, CTCL, Mycosis Fungoides, Cutaneous T Cell Lymphoma