PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
Recruiting
DEMETHER is a phase II trial exploring the maintenance of trastuzumab and pertuzumab fixed dose combination (FDC) for subcutaneous administration (SC, PHESGO) following trastuzumab deruxtecan (T-DXd) as induction treatment for HER2-positive unresectable locally recurrent or metastatic breast cancer (MBC) patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +35 locations
Conditions: HER2-positive Breast Cancer
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
Recruiting
The FRACTURE Trial is a prospective, non-randomized, single-arm, multicenter, interventional study in US and international centers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Scripps Health, La Jolla, California +33 locations
Conditions: Coronary Artery Disease, Coronary Artery Calcification
Long-term Outcomes Associated With Juvenile-onset Mycosis Fungoides and Lymphomatoid Papulosis
Recruiting
To follow up with all our participants with juvenile-onset mycosis fungoides, check on their status, and ask them or their parents about long term outcomes associated with their condition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Lymphomatoid Papulosis, Mycosis Fungoides
A Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma
Recruiting
To learn if the combination of axicabtagene ciloleucel (axi-cel) and glofitamab as first-line therapy in high-risk LBCL participants or as second-line therapy in LBCL participants can help to control the disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: B Cell Lymphoma
Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors
Recruiting
This is a first-in-human, dose finding and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C9074 alone and in combination with tislelizumab in participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Usc Norris Comprehensive Cancer Center (Nccc), Los Angeles, California +32 locations
Conditions: Advanced Solid Tumor
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
Recruiting
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: * To what extent does minocycline lower blood pressure? * Are such blood pressure effects mediated through changes in gut microbiota, gut leakiness, systemic inflammation, neuroinflammation, or some combination of these? Participants will be randomly assigned to treatment with minocycline or p... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/25/2025
Locations: UF Health Cardiology - Heart & Vascular Hospital, Gainesville, Florida
Conditions: Hypertension, Resistant to Conventional Therapy
Joint Patient and Caregiver Intervention for Older African Americans With Type 2 Diabetes
Recruiting
This study will test the preliminary efficacy of a joint patient/informal caregiver telephone-delivered intervention that includes diabetes education; problem solving around social needs; and behavioral activation for older African Americans with poorly controlled type 2 diabetes by randomizing 100 patient/caregiver dyads to the Joint Home intervention (n=50) and usual care (n=50) arms. The aims of the study are: Aim 1: To test the preliminary efficacy of home-based, joint patient and caregive... Read More
Gender:
ALL
Ages:
Between 50 years and 120 years
Trial Updated:
07/25/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Type 2 Diabetes
Phase I Study of HC-7366 for Acute Myeloid Leukemia
Recruiting
To find a recommended dose of HC-7366 to patients with AML. The safety and effects of this drug combination will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Acute Myeloid Leukemia
Prospective Evaluation of the Relation Between Different Questionnaires Measuring Radiation-induced Side-effect
Recruiting
To learn more about how you would rate the intensity or severity of your symptoms during or after radiation therapy using questionnaires with different rating scales.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Radiation
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
Recruiting
Substudy 01A is part of a larger research study that is testing experimental treatments for metastatic castration-resistant prostate cancer (mCRPC). The larger study is the umbrella study (U01). The goal of substudy 01A is to evaluate the safety and efficacy of opevesostat-based treatment combinations, or as a single agent, in participants with mCRPC. This substudy will have two phases: a safety lead-in phase and an efficacy phase. The safety lead-in phase will be used to evaluate the safety a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: UCSD Moores Cancer Center ( Site 0039), La Jolla, California +76 locations
Conditions: Prostatic Neoplasms, Castration-Resistant
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Recruiting
The goal of this clinical trial is to understand how the blood sugar-lowering hormone insulin works in healthy adults versus those who are at risk for type 2 diabetes. The study will use a drug called alpelisib, which interferes with insulin's actions in the body, to answer the study's main question: does the liver continue to respond to insulin's stimulation of fat production even when it loses the ability to stop making glucose (sugar) in response to insulin. Researchers will compare the impac... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/25/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Insulin Resistance, Prediabetic State, Overweight and Obesity, Non-Alcoholic Fatty Liver Disease
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
Recruiting
This study will compare how safe and effective sacituzumab tirumotecan is versus the treatment of physician's choice (TPC) in participants with advanced/metastatic gastroesophageal adenocarcinoma. The primary hypothesis of this study is sacituzumab tirumotecan is superior to TPC with respect to Overall Survival (OS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Banner MD Anderson Cancer Center ( Site 0119), Gilbert, Arizona +165 locations
Conditions: Gastroesophageal Cancer